转移生长因子β受体3抗体（TGF-βRⅢ）Anti-TGF Beta R3Beta glycan; Betaglycan; Betaglycan proteoglycan; BGCAN; TGF beta receptor type 3; TGF bet
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性能参数：

中文名称：转移生长因子β受体3抗体（TGF-βRⅢ）
英文名称：Anti-TGF Beta R3
别名：Beta glycan; Betaglycan; Betaglycan proteoglycan; BGCAN; TGF beta receptor type 3; TGF bet
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：Membrane Receptors Transforming growth factor beta is a multifunctional cytokine known to modulate several tissue development ａnd repair processes, including cell differentiation, cell cycle progression, cellular migration, adhesion, ａnd extracellular matrix production. There are 3 forms encoded by separate genes TGFB1, TGFB2, ａnd TGFB3. The diverse effects of TGF beta are mediated by the TGF beta receptors ａnd cell surface binding proteins. In addition to type I TGF beta receptor （TGFBR1） ａnd type II （TFGBR2）, type III （TGF beta III receptor） has been identified. It is a glycoprotein that binds TGF beta ａnd exists in both a membrane bound ａnd a soluble form. It may serve as a receptor accessory molecule in both the TGF beta ａnd fibroblast growth factor systems. TGF beta III receptor lacks a recognizable signaling domain ａnd has no clearly defined role in TGF beta signaling. Endothelial cells undergoing epithelial mesenchymal transformation express TGF beta III receptor, ａnd TGF beta III receptor specific antisera inhibits mesenchyme formation ａnd migration. Misexpression of TGF beta III receptor in nontransforming ventricular endothelial cells conferrs transformation in response to TGFB2. These results support a model where TGF beta III receptor localizes transformation in the heart ａnd plays an essential, nonredundant role in TGF beta signaling. TGF beta III receptor, or beta glycan, can function as an inhibin coreceptor with ActRII. TGF beta III receptor binds inhibin with high affinity ａnd enhances binding in cells coexpressing ActRII ａnd TGF beta III receptor. Inhibin forms crosslinked complexes with both recombinant ａnd endogenously expressed TGF beta III receptor ａnd ActRII. TGF beta III receptor confers inhibin sensitivity to cell lines that otherwise respond poorly to this hormone. The ability of TGF beta III receptor to inhibit or to facilitate inhibin antagonism of activin provides a variation on the emerging roles of proteoglycans as coreceptors modulating ligand receptor sensitivity, selectivity, ａnd function. Beta arrestin 2 binds to TGF beta III receptor, triggered by phosphorylation of the receptor on its cytoplasmic domain, likely at threonine 841. Phosphorylation is mediated by TGFBR2, which is itself a kinase, rather than by a G protein coupled receptor kinase. Association with beta arrestin 2 leads to internalization of both receptors ａnd downregulation of TGF beta signaling. The regulatory actions of beta arrestins are broader than previously appreciated, extending to the TGF beta receptor family as well.转化生长因子β受体Ⅲ，TGFβRⅢ

转移生长因子β受体3抗体（TGF-βRⅢ）的质量标准：

■其它名称：	Beta glycan; Betaglycan; Betaglycan proteoglycan; BGCAN; TGF beta receptor type 3; TGF bet
■交叉反应：	hu, mo, rat, pig, dog, shp, chk
■产品类型：	一抗
■应用领域:	/肿瘤/细胞生物/免疫学/神经生物学/信号转导/细胞凋亡/生长因子和激素/激酶和磷酸酶
■蛋白分子：	predicted molecular weight: 94kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human TGFBR3
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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由于化学产品的特殊性，恕不接受以下投诉：
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转移生长因子β受体3抗体（TGF-βRⅢ）Anti-TGF Beta R3的相关产品目录：







1mg/1ml 转移生长因子β受体3抗体（TGF-βRⅢ） Anti-TGF Beta R3 Beta glycan; Betaglycan; Betaglycan proteoglycan; BGCAN; TGF beta receptor type 3; TGF bet的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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