丝氨酸抑制蛋白激酶C底物抗体Anti-AKAP12/GravinA kinase （PRKA） anchor protein （gravin） 12; A kinase Anchor Protein 12; A kinase anchor pr
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性能参数：

中文名称：丝氨酸抑制蛋白激酶C底物抗体
英文名称：Anti-AKAP12/Gravin
别名：A kinase （PRKA） anchor protein （gravin） 12; A kinase Anchor Protein 12; A kinase anchor pr
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：Gravin （also known as A Kinase Anchor Protein 12, AKAP12） was cloned from a cDNA expression library screened with serum, from a myasthenia gravis patient. Antibodies to Gravin were found in 22 out of 72 myasthemia gravis patients ａnd absent in sera of normal individuals. This protein is a myristoylated high molecular weight cytoplasmic protein expressed in endothelial cells, cultured fibroblasts ａnd osteosarcoma cells ａnd highly expressed in the brain. Gravin can bind kinases like PKA ａnd PKC by different domains of the protein ａnd can localize these kinases to specific domains in the cell. Upon differentiation of NT2 cells to neurons （NT2 N）, Gravin expression is up regulated ａnd enriched at the inner peripheral cortex in close proximity to the plasma membrane. In differentiated cells, gravin is co-localized with PKCbII, PKCa ａnd PKA. Decreased binding of PKCa to gravin was found after activation of PKC.

丝氨酸抑制蛋白激酶C底物抗体的质量标准：

■其它名称：	A kinase （PRKA） anchor protein （gravin） 12; A kinase Anchor Protein 12; A kinase anchor pr
■交叉反应：	hu, mo, rat, dog
■产品类型：	一抗
■应用领域:	/激酶和磷酸酶
■蛋白分子：	predicted molecular weight: 185kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from the middle of human AKAP12
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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丝氨酸抑制蛋白激酶C底物抗体Anti-AKAP12/Gravin的相关产品目录：







1mg/1ml 丝氨酸抑制蛋白激酶C底物抗体 Anti-AKAP12/Gravin A kinase （PRKA） anchor protein （gravin） 12; A kinase Anchor Protein 12; A kinase anchor pr的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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