磷酸化细胞信号转导分子Smad-1抗体Anti-Phospho-Smad1（Ser206）Mothers against decapentaplegic homolog 1; BSP 1; BSP1 ; Dwarfin A; DwfA; hSMAD 1; hSMAD1;
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性能参数：

中文名称：磷酸化细胞信号转导分子Smad-1抗体
英文名称：Anti-Phospho-Smad1（Ser206）
别名：Mothers against decapentaplegic homolog 1; BSP 1; BSP1 ; Dwarfin A; DwfA; hSMAD 1; hSMAD1;
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene ＇mothers against decapentaplegic＇ （Mad） ａnd the C. elegans gene Sma. SMAD proteins are signal transducers ａnd transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins （BMPs）, which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development ａnd immune responses. In response to BMP ligands, this protein can be phosphorylated ａnd activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 ａnd SMURF2, ａnd undergoes ubiquitination ａnd proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq].Subcellular Location : Cytoplasm. Nucleus.Tissue Specificity : Ubiquitous. Highest expression seen in the heart ａnd skeletal muscle.Similarity : Belongs to the dwarfin/SMAD family.Contains 1 MH1 （MAD homology 1） domain.Contains 1 MH2 （MAD homology 2） domain.Smads发现的TGF-β信号转导途径中一个重要的新基因家族.是TGF-β特异的细胞内信号转导分子，SMAD1属于受体激活的SMADs.有学者认为：Smad1在某些肿瘤中发生突变,有可能是一种肿瘤抑制基因。

磷酸化细胞信号转导分子Smad-1抗体的质量标准：

■其它名称：	Mothers against decapentaplegic homolog 1; BSP 1; BSP1 ; Dwarfin A; DwfA; hSMAD 1; hSMAD1;
■交叉反应：	hu, mo, rat
■产品类型：	一抗磷酸化抗体
■应用领域:	/肿瘤/免疫学/信号转导/细胞凋亡/转录调节因子
■蛋白分子：	predicted molecular weight: 52kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated Synthesised phosphopeptide derived from human Smad1 around the phosphorylation site of Ser206
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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由于化学产品的特殊性，恕不接受以下投诉：
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磷酸化细胞信号转导分子Smad-1抗体Anti-Phospho-Smad1（Ser206）的相关产品目录：







1mg/1ml 磷酸化细胞信号转导分子Smad-1抗体 Anti-Phospho-Smad1（Ser206） Mothers against decapentaplegic homolog 1; BSP 1; BSP1 ; Dwarfin A; DwfA; hSMAD 1; hSMAD1;的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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