信号转导和转录激活因子2抗体Anti-STAT2signal transducers ａnd activators of transduction2; 1600010G07Rik; AW496480; Homo sapiens
360TIYO.COM-上海田源公司

性能参数：

中文名称：信号转导和转录激活因子2抗体
英文名称：Anti-STAT2
别名：signal transducers ａnd activators of transduction2; 1600010G07Rik; AW496480; Homo sapiens
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：STATs are Signal Transducers ａnd Activators of Transcription. STATs were originally discovered as two proteins （STAT1 ａnd STAT2） which were involved in interferon alpha （IFN alpha） ａnd IFN gamma signal transduction. Since then, several additional STAT proteins have been identified （STAT3, 4, 5a, 5b, ａnd 6）. STATs are a family of cytoplasmic proteins that participate in cellular responses to cytokines ａnd growth factors. STATs undergo tyrosine phosphorylation in response to growth factor or cytokine signaling. This phosphorylation results in dimerization ａnd translocation of STAT proteins to the nucleus. In some cases this process is mediated by JAK Kinases （Janus Kinases 1, 2, ａnd 3）. For maximum activation of these proteins, phosphorylation at specific tyrosine ａnd serine residues may be required in STAT1 alpha, 3, 4, ａnd 5. Many cytokines involved in immune responses utilize the Jak-STAT signaling pathway. Jaks are receptor-associated protein tyrosine kinases. Abnormal signaling of the JAK-STAT pathway has been implicated in hematopoietic disorders including SCID ａnd leukemia, ａnd programming gene expression in biological events such as embryonic development, apoptosis, organogenesis, innate immunity, adaptive immunity ａnd cell growth regulation. STAT1 knockout mice are defective in interferon-mediated functions. STAT4 ａnd STAT6 knockout mice show defective responses to IL12 ａnd IL4, respectively. Analyses of STAT5a ａnd STAT5b knockout mice reveal important roles in prolactin-mediated mammary gland development ａnd growth hormone-mediated induction of sexual dimorphism, respectively. Conditional knockout study of STAT3 demonstrates its critical roles in cytokine-mediated functions in several tissues, including T cells, macrophages, skin, ａnd mammary gland. STAT1/STAT2 form a heterodimer which, in association with a DNA-binding adapter protein, p48/IFN regulatory factor 9 （IRF9）, is part of the ISGF3 transcription factor complex.Specific functions of the various members of the STAT family are poorly understood. STAT1 ａnd STAT2 form heterodimers that function as more potent inducers of transcription than the STAT1 homodimer. The unique acidic domain of the carboxy-terminal region of STAT2 may interact with cAMP-response-element binding protein. STAT2 has been shown to be activated by IFNalpha/beta ａnd associate with the transcription factors p48, ａnd P300.转录调节因子（Transcriptin Regulators） STAT-信号转导和转录激活因子蛋白家族是近年来发现的一类转录因子.通过JAK-STAT途径介导许多由细胞因子诱导的反应,参与细胞的信号转导和转录。

信号转导和转录激活因子2抗体的质量标准：

■其它名称：	signal transducers ａnd activators of transduction2; 1600010G07Rik; AW496480; Homo sapiens
■交叉反应：	hu, mo, rat
■产品类型：	一抗
■应用领域:	/细胞生物/转录调节因子
■蛋白分子：	predicted molecular weight: 93（hu, rat）; 101（mo）kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human STAT2 C-terminus
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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信号转导和转录激活因子2抗体Anti-STAT2的相关产品目录：







1mg/1ml 信号转导和转录激活因子2抗体 Anti-STAT2 signal transducers ａnd activators of transduction2; 1600010G07Rik; AW496480; Homo sapiens 的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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