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ATP结合转运因子2抗体 田源一抗
点击次数:165发布时间:2012/8/14 10:16:35
更新日期:2013/6/26 15:47:54
所 在 地:其它
产品型号:Anti-TAP2/ABCB3
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详细内容
ATP结合转运因子2抗体Anti-TAP2/ABCB3ABC18; ABCB3; Peptide supply factor 2; Peptide transporter PSF2; Peptide transporter TAP2;
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性能参数:
中文名称:ATP结合转运因子2抗体
英文名称:Anti-TAP2/ABCB3
别名:ABC18; ABCB3; Peptide supply factor 2; Peptide transporter PSF2; Peptide transporter TAP2;
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:TAP is an integral transmembrane protein involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. It is a heterodimer of TAP1 and TAP2, and the peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2. TAP is inducible by interferon gamma and belongs to the ABC transporter family, MDR subfamily. TAP also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. TAP is inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. It is inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP and prevents the conformational rearrangement of TAP induced by peptide binding.Subcellular Location : Membrane; Multi-pass membrane protein.Similarity : Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.Contains 1 ABC transmembrane type-1 domain.Contains 1 ABC transporter domain.Subunit : Heterodimer of TAP1 and TAP2. Interacts with Epstein-Barr virus BLNF2a.ATP结合转运因子2抗体的质量标准:
■其它名称: | ABC18; ABCB3; Peptide supply factor 2; Peptide transporter PSF2; Peptide transporter TAP2; |
■交叉反应: | hu, mo, rat, cow, dog, pig, hrs, Rb |
■产品类型: | 一抗 |
■应用领域: | /肿瘤/细胞生物/免疫学/信号转导/转录调节因子 |
■蛋白分子: | predicted molecular weight: 75kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated synthetic peptide derived from human TAP2 (488-530aa) |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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ATP结合转运因子2抗体Anti-TAP2/ABCB3的相关产品目录:
1mg/1ml ATP结合转运因子2抗体 Anti-TAP2/ABCB3 ABC18; ABCB3; Peptide supply factor 2; Peptide transporter PSF2; Peptide transporter TAP2;的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
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