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磷酸化p38MAPK抗体 田源一抗磷酸化抗体
点击次数:137发布时间:2012/8/14 10:17:08
更新日期:2013/6/26 15:47:54
所 在 地:其它
产品型号:Anti-phospho-MAPK14(Thr180)
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详细内容
磷酸化p38MAPK抗体Anti-phospho-MAPK14(Thr180)MAPK14(phospho T180); CSAID Binding Protein 1; CSAID binding protein; CSBP 1; CSBP 2; CSBP
360TIYO.COM-上海田源公司
性能参数:
中文名称:磷酸化p38MAPK抗体
英文名称:Anti-phospho-MAPK14(Thr180)
别名:MAPK14(phospho T180); CSAID Binding Protein 1; CSAID binding protein; CSBP 1; CSBP 2; CSBP
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:p38 is a 38 kDa Stress Activated Protein Kinase/Map Kinase (SAPK/MAPK) that is fully activated by dual phosphorylation on threonine 180 and tyrosine 182, within the activation loop. p38 MAPK plays a critical role in the initiation of G2 delay after ultraviolet radiation; gene knock out studies have also revealed a critical role for p38 in cardiac remodeling. Downstream targets of p38 include the transcription factors ELK1 and ATF2 and the kinases MAPKAPK2 and MAPKAPK5. p38 MAPK plays a role in the production of IL6 and is thought to stabilize erythropoietin production during hypoxic stress. It is activated by environmental stress, many proinflammatory cytokines and lipopolysaccharide. Dual phosphorylation by MAP2K3 and MAP2K6 is required for activation of p38 MAPK. It interacts with MAX, Cdc25B, Cdc25C and binds to the kinase interaction domain in the protein tyrosine phosphatase PTPRR; this interaction retains p38 MAPK in the cytoplasm.Subcellular Location : Cytoplasm. Nucleus.Tissue Specificity : Brain, heart, placenta, pancreas and skeletal muscle. Expressed to a lesser extent in lung, liver and kidney.Similarity : Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.Contains 1 protein kinase domain.Subunit : inds to a kinase interaction motif within the protein tyrosine phosphatase, PTPRR.丝裂原活化蛋白激酶p38(p38 MAPK、磷酸化pERK)参与细胞生长、增殖、分化、死亡及细胞间的功能同步等多种生理过程。 P-p38MAPK是丝裂原活化蛋白激酶家族中的成员,大量研究显示p38在能量代谢中具有广泛的作用。p38参与脂肪组织、骨骼肌、胰岛细胞和肝脏等组织、器官的能量代谢。 p38 MAPK:作为细胞信号传递系统的交汇点,细胞内普遍存在的一条信号转导通路。细胞外的物理应激因子,如高渗透压、热休克、紫外线以及细胞因子、内毒素脂多糖(LPS)等都能激活该途径,诱导细胞内蛋白质合成与分泌、细胞分化及凋亡等生物效应。p38 MAPK还能与细胞内其他信号通路之间相互作用,是细胞内信号传递系统的交汇点或共同通路。p38 MAPK一旦被激活后,可以使一些转录因子如CREB、转录活化因子-1(activating factor-1, ATF-1)、ATF-2及活化蛋白-1(AP-1)等的丝氨酸和苏氨酸位点磷酸化,活化这些转录因子,从而调节目的基因的表达。 p38(丝氨酸位点)磷酸化后可以直接激活转录因子,参与机体的应激反应。磷酸化p38MAPK抗体的质量标准:
■其它名称: | MAPK14(phospho T180); CSAID Binding Protein 1; CSAID binding protein; CSBP 1; CSBP 2; CSBP |
■交叉反应: | hu, mo, rat, hrs, Rb, pig, chk, dog |
■产品类型: | 一抗磷酸化抗体 |
■应用领域: | /肿瘤/免疫学/信号转导/转录调节因子/激酶和磷酸酶 |
■蛋白分子: | predicted molecular weight: 41kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated Synthesised phosphopeptide derived from human MAPK14 around the phosphorylation site of Thr180 |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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磷酸化p38MAPK抗体Anti-phospho-MAPK14(Thr180)的相关产品目录:
1mg/1ml 磷酸化p38MAPK抗体 Anti-phospho-MAPK14(Thr180) MAPK14(phospho T180); CSAID Binding Protein 1; CSAID binding protein; CSBP 1; CSBP 2; CSBP的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
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