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磷酸化信号转导和转录激活因子3抗体 田源一抗磷酸化抗体
点击次数:192发布时间:2012/8/14 10:18:12
更新日期:2013/6/26 15:47:37
所 在 地:其它
产品型号:Anti-phospho-STAT3 (Ser727)
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详细内容
磷酸化信号转导和转录激活因子3抗体Anti-phospho-STAT3 (Ser727)STAT3(Phospho-Ser727); p-STAT3; p-STAT3(Ser727); Acute Phase Response Factor; APRF; DNA bi
360TIYO.COM-上海田源公司
性能参数:
中文名称:磷酸化信号转导和转录激活因子3抗体
英文名称:Anti-phospho-STAT3 (Ser727)
别名:STAT3(Phospho-Ser727); p-STAT3; p-STAT3(Ser727); Acute Phase Response Factor; APRF; DNA bi
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:STATs (signal transducers and activators of transcription) were originally discovered as two proteins (STAT1 and STAT2) which were involved in interferon alpha (IFN alpha) and IFN gamma signal transduction. Since then, several additional STAT proteins have been identified (STAT3, 4, 5a, 5b, and 6). STATs undergo tyrosine phosphorylation in response to growth factor or cytokine signaling. This phosphorylation results in dimerization and translocation of STAT proteins to the nucleus. In some cases this process is mediated by JAK Kinases (Janus Kinases 1, 2, and 3). For maximum activation of these proteins, phosphorylation at specific tyrosine and serine residues may be required in STAT1 alpha, 3, 4, and 5.Specific functions of the various members of the STAT family are poorly understood. STAT3 has been shown to be activated by IFN alpha but not IFN beta. The transcription factors associated with STAT3 are cJun and cyclic AMP responsive enhancer binding protein (CREB). Deletion of the STAT3 gene in knock out mice was lethal at the early embryonic stage.磷酸化信号转导和转录激活因子3抗体的质量标准:
■其它名称: | STAT3(Phospho-Ser727); p-STAT3; p-STAT3(Ser727); Acute Phase Response Factor; APRF; DNA bi |
■交叉反应: | hu, mo, rat, Rb, cow, pig, Gpig, dog, chk, shp |
■产品类型: | 一抗磷酸化抗体 |
■应用领域: | /肿瘤/细胞生物/免疫学/信号转导/细胞凋亡/转录调节因子 |
■蛋白分子: | predicted molecular weight: 85kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated Synthesised phosphopeptide derived from human STAT3 around the phosphorylation site of Ser727 |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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磷酸化信号转导和转录激活因子3抗体Anti-phospho-STAT3 (Ser727)的相关产品目录:
1mg/1ml 磷酸化信号转导和转录激活因子3抗体 Anti-phospho-STAT3 (Ser727) STAT3(Phospho-Ser727); p-STAT3; p-STAT3(Ser727); Acute Phase Response Factor; APRF; DNA bi的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
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