转化生长因子β1抗体Anti-TGF Beta 1TGFβ1 TGFβ2 TGFβ3; CED; Diaphyseal dysplasia 1 progressive; TGF-Beta 1; DPD 1; DPD1; TGF
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性能参数：

中文名称：转化生长因子β1抗体
英文名称：Anti-TGF Beta 1
别名：TGFβ1 TGFβ2 TGFβ3; CED; Diaphyseal dysplasia 1 progressive; TGF-Beta 1; DPD 1; DPD1; TGF
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：This gene encodes a member of the transforming growth factor beta （TGFB） family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, ａnd other functions in many cell types. Many cells have TGFB receptors, ａnd the protein positively ａnd negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide （LAP） ａnd a mature TGFB1 peptide, ａnd is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, ａnd a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, ａnd mutations in this gene result in Camurati-Engelmann disease.Subcellular Location : Secreted, extracellular space, extracellular matrix.Tissue Specificity : Highly expressed in bone. Abundantly expressed in articular cartilage ａnd chondrocytes ａnd is increased in osteoarthritis （OA）. Co-localizes with ASPN in chondrocytes within OA lesions of articular cartilage.Similarity : Belongs to the TGF-beta family.Subunit : Homodimer; disulfide-linked, or heterodimer with TGFB2. Secreted ａnd stored as a biologically inactive form in the extracellular matrix in a 290 kDa complex （large latent TGF-beta1 complex） containing the TGFB1 homodimer, the latency-associated peptide （LAP）, ａnd the latent TGFB1 binding protein-1 （LTBP1）. The complex without LTBP1 is known as the＇small latent TGF-beta1 complex＇. Dissociation of the TGFB1 from LAP is required for growth factor activation ａnd biological activity. Release of the large latent TGF-beta1 complex from the extracellular matrix is carried out by the matrix metalloproteinase MMP3 （By similarity）. May interact with THSD4; this interaction may lead to sequestration by FBN1 microfibril assembly ａnd attenuation of TGFB signaling. Interacts with the serine proteases, HTRA1 ａnd HTRA3: the interaction with either inhibits TGFB1-mediated signaling. The HTRA protease activity is required for this inhibition （By similarity）. Interacts with CD109, DPT ａnd ASPN.生长因子和激素（ Growth Factor ａnd Hormones） TGF是一种多效生长因子，对上皮细胞增值有潜在抑制作用，可抑制肿瘤生长用于许多恶性肿瘤如:胃癌、肺癌、膀胱癌、肾癌、前列腺癌、结肠癌等多种恶性肿瘤的研究。 TGFβ超级家族由为数众多的生长的分化因子组成,包括转移生长因子β1，2和3（TGF β1，TGF β2，TGF β3）；胎盘生长因子（PTGF-β）；生长/分化因子（GDFs）；缪氏抑制物（MIS）；骨形态形成蛋白（BMPs）；交织细胞元神经生长因子（GDNF）;抑制素和活化素（α, β-A,和β-C），Lefty和Nodal。 TGF超级家族成员参与胚胎发育和成体组织体内平衡。TGF-β1抗体与TGF-β2和TGF-β3没有交叉反应。与豚鼠有大部分交叉.

转化生长因子β1抗体的质量标准：

■其它名称：	TGFβ1 TGFβ2 TGFβ3; CED; Diaphyseal dysplasia 1 progressive; TGF-Beta 1; DPD 1; DPD1; TGF
■交叉反应：	hu
■产品类型：	一抗
■应用领域:	/细胞生物/神经生物学/信号转导/生长因子和激素/细胞因子/新陈代谢
■蛋白分子：	predicted molecular weight: 44kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human TGF beta 1
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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转化生长因子β1抗体Anti-TGF Beta 1的相关产品目录：







1mg/1ml 转化生长因子β1抗体 Anti-TGF Beta 1 TGFβ1 TGFβ2 TGFβ3; CED; Diaphyseal dysplasia 1 progressive; TGF-Beta 1; DPD 1; DPD1; TGF 的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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