磷酸化端粒酶逆转录酶抗体Anti-phospho-TERT（Ser1125）p-TERT（Ser1125）; TERT（phospho S1125）; EST2; hEST2; TCS1; Telomerase associated protein 2;
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性能参数：

中文名称：磷酸化端粒酶逆转录酶抗体
英文名称：Anti-phospho-TERT（Ser1125）
别名：p-TERT（Ser1125）; TERT（phospho S1125）; EST2; hEST2; TCS1; Telomerase associated protein 2;
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Telomerase are large DNA-protein complexes with telomerase expression being the subject of recent research due to its link to cell immortalization. Recent evidence has shown that MYC upregulates the catalytic subunit of telomerase, TERT, ａnd that TERT cooperates with HPV E7 in cell immortalization. Ever since the discovery that telomeres are short in cancer cells ａnd telomerase is activated in immortal cells, telomerase has been associated with oncogenes. During the past year, major advances have been made in understanding the link between telomerase expression ａnd cell immortality. Studies of yeast telomeres have revealed an unexpected role for the non-homologous end-joining machinery in telomere maintenance ａnd have provided the first definitive evidence that telomeres play a critical role in meiosis. Identification of new telomere proteins has led to a better understanding of vertebrate telomere structure ａnd function.端粒酶逆转录酶hTERT是构成端粒酶的组分,是端粒酶活性的必需和限速成分,其水平决定细胞端粒酶的活性.抑制hTERT可降低端粒酶的活性,从而抑制瘤细胞生长.目前对hTERT的研究已成为端粒酶研究的热点问题,已发现TERT蛋白表达在肿瘤诊断中有重要意义,并制备了hTERT抗体及应用核酶技术等来抑制hTERT蛋白的表达,抑制端粒酶活性,从而抑制肿瘤的生长.端粒反转录酶又称端粒酶催化亚单位 （hTRT；Telomerase catalytic subunit；HEST2；Telomerase-associated protein 2；TP2；Telomerase reverse transcriptase；telomerase catalytic subunit）是细胞永生化及恶性肿瘤发生过程中的端粒酶活化的主要限速步骤。hTRT基因表达可以反映端粒酶活性，与端粒酶活性具有平行关系.

磷酸化端粒酶逆转录酶抗体的质量标准：

■其它名称：	p-TERT（Ser1125）; TERT（phospho S1125）; EST2; hEST2; TCS1; Telomerase associated protein 2;
■交叉反应：	hu, mo, rat
■产品类型：	一抗磷酸化抗体
■应用领域:	/肿瘤/免疫学/细胞凋亡/转录调节因子
■蛋白分子：	predicted molecular weight: 124kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated Synthesised phosphopeptide derived from human TERT around the phosphorylation site of Ser1125
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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磷酸化端粒酶逆转录酶抗体Anti-phospho-TERT（Ser1125）的相关产品目录：







1mg/1ml 磷酸化端粒酶逆转录酶抗体 Anti-phospho-TERT（Ser1125） p-TERT（Ser1125）; TERT（phospho S1125）; EST2; hEST2; TCS1; Telomerase associated protein 2; 的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

查询其它抗体目录请点击本公司化工仪器网链接：http://www.chem17.com/st233816/erlist_675408.html

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