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zeta相关蛋白70抗体 田源一抗
点击次数:166发布时间:2012/8/15 9:12:49
更新日期:2013/6/26 15:38:07
所 在 地:其它
产品型号:Anti-ZAP-70
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详细内容
zeta相关蛋白70抗体Anti-ZAP-70zeta-associated protein 70; ZAP70; ZAP-70=protein tyrosine kinase Syk homolog {SH2-like a
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性能参数:
中文名称:zeta相关蛋白70抗体
英文名称:Anti-ZAP-70
别名:zeta-associated protein 70; ZAP70; ZAP-70=protein tyrosine kinase Syk homolog {SH2-like a
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.ZAP70 为慢性淋巴细胞性白血病的预后指标。ZAP70是T细胞标志性抗原,正常T细胞含量较高,而在B细胞中不存在或表达极低。部分慢淋患者的B细胞中发现有ZAP70异常高表达,这类患者预后差,需进行化疗;而无/低ZAP70表达的患者预后好,一般可不做化疗。zeta相关蛋白70抗体的质量标准:
■其它名称: | zeta-associated protein 70; ZAP70; ZAP-70=protein tyrosine kinase Syk homolog {SH2-like a |
■交叉反应: | hu, mo, rat, hrs, Rb, cow, pig, Gpig, dog, chk |
■产品类型: | 一抗 |
■应用领域: | /肿瘤/细胞生物/免疫学/信号转导/转录调节因子/激酶和磷酸酶/细胞膜受体/t-淋巴细胞 |
■蛋白分子: | predicted molecular weight: 68kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated synthetic peptide derived from human ZAP-70 C-terminus |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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zeta相关蛋白70抗体Anti-ZAP-70的相关产品目录:
1mg/1ml zeta相关蛋白70抗体 Anti-ZAP-70 zeta-associated protein 70; ZAP70; ZAP-70=protein tyrosine kinase Syk homolog {SH2-like a的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
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