硫氧还蛋白抗体Anti-ThioredoxinADF; Surface associated sulphydryl protein;Thioredoxin-1; Thioredoxin 1; Thioredoxin1; TX
360TIYO.COM-上海田源公司

性能参数：

中文名称：硫氧还蛋白抗体
英文名称：Anti-Thioredoxin
别名：ADF; Surface associated sulphydryl protein;Thioredoxin-1; Thioredoxin 1; Thioredoxin1; TX
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：Thioredoxins （Trx） are small, multi functional proteins with oxidoreductase activity ａnd are ubiquitous in essentially all living cells. Trx contains a redox active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site. The two cysteine residues in the conserved active centers can be oxidized to form intramolecular disulfide bonds. Reduction of the active site disulfide in oxidized Trx is catalyzed by Trx reductase with NADPH as the electron donor. The reduced Trx is a hydrogen donor for ribonucleotide reductase, the essential enzyme for DNA synthesis, ａnd a potent general protein disulfide reductase with numerous functions in growth ａnd redox regulations. Specific protein disulfide targets for reduction by Trx include protein disulfide isomerase （PDI） ａnd a number of transcription factors such as p53, NFkB ａnd AP1.Trx is also capable of removing H2O2, particularly when it is coupled with either methionine sulfoxide reductase or several isoforms of peroxiredoxins.TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; ａnd Group II, which are composed of fusion proteins of TRX ａnd additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein＇s surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes ａnd transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide ａnd certain radicals, ａnd by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm ａnd the mitochondria. Higher plants contain more types （at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana）, two of which （types f amd m） are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.Subcellular Location : Nucleus. Cytoplasm. Secreted. Note=Secreted by a leaderless secretory pathway. Predominantly in the cytoplasm in non irradiated cells. Radiation induces translocation of TRX from the cytoplasm to the nucleus.Similarity : Belongs to the thioredoxin family. Contains 1 thioredoxin domain.Subunit : Homodimer; disulfide-linked. Interacts with TXNIP through the redox-active site. Interacts with MAP3K5 ａnd CASP3. In case of infection, interacts with S.typhimurium protein slrP. Interacts with APEX1; the interaction stimulates the FOS/JUN AP-1 DNA-binding activity in a redox-dependent manner.硫氧还蛋白（Thioredoxin，Trx）是一类广泛存在于生物体内的多功能酸性蛋白，分子量约12kDa，是一种小分子含硒蛋白质,参与细胞的一系列生化反应，包括酶活性的调节、转录因子的调控等，是重要的酶活力调节蛋白。硫氧还蛋白的功能绝大多数是依赖于硫氧还蛋白还原靶蛋白中的二硫键。所有硫氧还蛋白均有一个保守的活性中心，Trp-Cys-Gly（Ala）-Pro-Cys，活性中心有两个具有氧还活性的半胱氨酸残基。

硫氧还蛋白抗体的质量标准：

■其它名称：	ADF; Surface associated sulphydryl protein;Thioredoxin-1; Thioredoxin 1; Thioredoxin1; TX
■交叉反应：	hu, mo, rat, pig, dog, cow, hrs, Rb
■产品类型：	一抗
■应用领域:	/肿瘤/细胞生物/免疫学/信号转导/转录调节因子
■蛋白分子：	predicted molecular weight: 12kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human Thioredoxin （65-105aa）
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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部分进口产品投诉须按照进口产品要求的检测方法提供证据。
由于化学产品的特殊性，恕不接受以下投诉：
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硫氧还蛋白抗体Anti-Thioredoxin的相关产品目录：







1mg/1ml 硫氧还蛋白抗体 Anti-Thioredoxin ADF; Surface associated sulphydryl protein;Thioredoxin-1; Thioredoxin 1; Thioredoxin1; TX的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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