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髓系细胞触发受体样转录因子2抗体 田源一抗
点击次数:126发布时间:2012/8/15 9:13:19
更新日期:2013/6/26 15:37:55
所 在 地:其它
产品型号:Anti-TREML2/TLT2
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详细内容
髓系细胞触发受体样转录因子2抗体Anti-TREML2/TLT2C6orf76; Chromosome 6 open reading frame 76; FLJ13693; MGC149715; MGC149716; TLT 2; TLT2;
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性能参数:
中文名称:髓系细胞触发受体样转录因子2抗体
英文名称:Anti-TREML2/TLT2
别名:C6orf76; Chromosome 6 open reading frame 76; FLJ13693; MGC149715; MGC149716; TLT 2; TLT2;
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:TREML2 is expressed throughout B cell development in addition to being expressed on macrophages and neutrophils and is the only TREM molecule to be found on lymphocytes. TREML2 is expressed on B lineage cells early in development, and the highest level of expression is detected on those mature peripheral B cell subpopulations that are involved in the initial humoral immune response against bacterial pathogens. TREML2 is unique in that it lacks either the conserved transmembrane lysine residue or ITAM/ITIMs within its own cytoplasmic domain. Thus, TREML2 does not exhibit any of the features associated with classical tyrosine-based signaling. Monocytes in the bone marrow or peripheral blood do not express detectable levels of TREML2, but its expression is up-regulated in conjunction with differentiation into macrophages. TREML2 is present on neutrophils in the bone marrow as well as the periphery, and inflammatory stimuli result in a dramatic increase in the expression of TREML2 on these cells in vivo.TREML2 is a single-pass type I membrane protein, and it contains 1 Ig-like V-type (immunoglobulin-like) domain. It is a cell surface receptor that may play a role in the innate and adaptive immune response. TREML2 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 and TREM2, but it has distinct structural and functional properties. Subcellular Location : Cell membrane; Single-pass type I membrane protein.Tissue Specificity : Detected in cultured B cells, T cell leukemia and monocyte leukemia. Expressed constitutively on CD8 T-cells and induced on CD4 T-cells after activation.Similarity : Contains 1 Ig-like V-type (immunoglobulin-like) domain.Subunit : Interacts with CD276 and this interaction enhances T-cell activation.髓系细胞触发受体样转录因子2抗体的质量标准:
■其它名称: | C6orf76; Chromosome 6 open reading frame 76; FLJ13693; MGC149715; MGC149716; TLT 2; TLT2; |
■交叉反应: | hu, mo, rat, cow, dog, pig |
■产品类型: | 一抗 |
■应用领域: | /免疫学/t-淋巴细胞/b-淋巴细胞 |
■蛋白分子: | predicted molecular weight: 33kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated synthetic peptide derived from human TREML2 |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//Flow-Cyt=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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髓系细胞触发受体样转录因子2抗体Anti-TREML2/TLT2的相关产品目录:
1mg/1ml 髓系细胞触发受体样转录因子2抗体 Anti-TREML2/TLT2 C6orf76; Chromosome 6 open reading frame 76; FLJ13693; MGC149715; MGC149716; TLT 2; TLT2; 的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
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