DNA拓普西异构酶Ⅱ抗体Anti-TOPO II/TOPO II AlphaDNA topoisomeraseⅡalpha; DNA topoisomerase 2-alpha; DNA topoisomerase II, alpha isozyme; T
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性能参数：

中文名称：DNA拓普西异构酶Ⅱ抗体
英文名称：Anti-TOPO II/TOPO II Alpha
别名：DNA topoisomeraseⅡalpha; DNA topoisomerase 2-alpha; DNA topoisomerase II, alpha isozyme; T
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：This gene encodes a DNA topoisomerase, an enzyme that controls ａnd alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, ａnd the relief of torsional stress that occurs during DNA transcription ａnd replication. It catalyzes the transient breaking ａnd rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromsome 17 ａnd the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents ａnd a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq].拓扑异构酶II是一种能催化DNA 拓扑异构体相互变换，调节DNA三维结构的核酶。与染色质或染色体的组装与分组装、基因组复制、DNA重组、基因转录及DNA损伤后修复等有密切的关系。许多人的恶性肿瘤都有拓扑异构酶II的过表达，因此，拓扑异构酶II是许多化疗药的靶标。大部分以拓扑异构酶II为重要靶标抗肿瘤的化疗药物是通过稳定的DNA与拓扑异构酶II的复合物激发凋亡的。

DNA拓普西异构酶Ⅱ抗体的质量标准：

■其它名称：	DNA topoisomeraseⅡalpha; DNA topoisomerase 2-alpha; DNA topoisomerase II, alpha isozyme; T
■交叉反应：	hu, mo, rat
■产品类型：	一抗
■应用领域:	/肿瘤/转录调节因子/激酶和磷酸酶
■蛋白分子：	predicted molecular weight: 168kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human TOPO II alpha
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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部分进口产品投诉须按照进口产品要求的检测方法提供证据。
由于化学产品的特殊性，恕不接受以下投诉：
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DNA拓普西异构酶Ⅱ抗体Anti-TOPO II/TOPO II Alpha的相关产品目录：







1mg/1ml DNA拓普西异构酶Ⅱ抗体 Anti-TOPO II/TOPO II Alpha DNA topoisomeraseⅡalpha; DNA topoisomerase 2-alpha; DNA topoisomerase II, alpha isozyme; T的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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