血管内皮生长因子受体1抗体Anti-VEGFR1/FLT1VEGF-R1; VEGFR-1; VEGF Receptor 1: vascular permeability factor receptor; vascular endothe
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性能参数：

中文名称：血管内皮生长因子受体1抗体
英文名称：Anti-VEGFR1/FLT1
别名：VEGF-R1; VEGFR-1; VEGF Receptor 1: vascular permeability factor receptor; vascular endothe
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：VEGF Receptor 1 （also known as FLT） belongs to the src gene family ａnd shows tyrosine protein kinase activity that is important for the control of cell proliferation ａnd differentiation. The protein acts as a receptor for VEGF, VEGFB ａnd PGF. An alternatively spliced form of the gene produces a soluble protein （sFlt1） which binds vascular endothelial growth factor （VEGF） with high affinity. sFlt1 has a higher affinity for VEGF indicating that it may function as an inhibitor in the VEGF response. VEGF Receptor 1 is specifically expressed in most vascular endothelial cells ａnd peripheral blood monocytes.Subcellular Location : Isoform 1: Cell membrane; Single-pass type I membrane protein. Endosome. Note=Autophosphorylation promotes ubiquitination ａnd endocytosis；Isoform 2: Secreted；Isoform 3: Secreted；Isoform 4: Secreted；Isoform 5: Cytoplasm （Potential）；Isoform 6: Cytoplasm （Potential）；Isoform 7: Cytoplasm （Potential）.Tissue Specificity : Detected in normal lung, but also in placenta,liver, kidney, heart ａnd brain tissues. Specifically expressed in most of the vascular endothelial cells, ａnd also expressed in peripheral blood monocytes. Isoform 2 is strongly expressed in placenta. Isoform 3 is expressed in corneal epithelial cells （at protein level）. Isoform 3 is expressed in vascular smooth muscle cells （VSMC）.Similarity : Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.Contains 7 Ig-like C2-type （immunoglobulin-like）domains.Contains 1 protein kinase domain.Subunit : Interacts with VEGFA, VEGFB ａnd PGF. Monomer in the absence of bound VEGFA, VEGFB or PGF. Homodimer in the presence of bound VEGFA, VEGFB ａnd PGF. Can also form a heterodimer with KDR.Interacts （when tyrosine phosphorylated） with CBL, CRK, GRB2, NCK1,PIK3R1, PLCG1 ａnd PTPN11. Interacts with GNB2L1/RACK1. Identified in a complex with CBL ａnd CD2AP.VEGFR1/Flt1是一种细胞膜受体激酶，对血管内皮生长因子有高度的亲和性，主要功能是参与血管内皮细胞生长和血管生成的调控。用于各种恶性肿瘤的研究。

血管内皮生长因子受体1抗体的质量标准：

■其它名称：	VEGF-R1; VEGFR-1; VEGF Receptor 1: vascular permeability factor receptor; vascular endothe
■交叉反应：	hu, rat, mo
■产品类型：	一抗
■应用领域:	/肿瘤/细胞生物/免疫学/发育生物学/神经生物学/生长因子和激素/激酶和磷酸酶/细胞膜受体/细胞表面分子
■蛋白分子：	predicted molecular weight: 147kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human VEGFR1 C-terminus
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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血管内皮生长因子受体1抗体Anti-VEGFR1/FLT1的相关产品目录：







1mg/1ml 血管内皮生长因子受体1抗体 Anti-VEGFR1/FLT1 VEGF-R1; VEGFR-1; VEGF Receptor 1: vascular permeability factor receptor; vascular endothe的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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