胶质细胞系源性神经营养因子受体α2抗体Anti-GDNF Receptor alpha 2GDNF family receptor alpha 2; GDNF Receptor α2;GDNF receptor beta; GDNFR beta; GDNFRB; GFR
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性能参数：

中文名称：胶质细胞系源性神经营养因子受体α2抗体
英文名称：Anti-GDNF Receptor alpha 2
别名：GDNF family receptor alpha 2; GDNF Receptor α2;GDNF receptor beta; GDNFR beta; GDNFRB; GFR
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：Glial cell line-derived neurotrophic factor （GDNF） ａnd neurturin （NTN） are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival ａnd differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol（GPI）-linked cell surface receptor for both GDNF ａnd NTN, ａnd mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene.Members of the glial cell line-derived neurotrophic factor（GDNF） family, including GDNF ａnd neurturin （NTN）,play key roles in the control of vertebrate neuron survivaland differentiation. Physiological responses to NTN requirethe presence of a novel glycosylphosphadidylinositollinked protein NTNRa, which is a cell surface receptor forNTN. The cDNAs encoding NTNRa from human, rat,chicken, ａnd mouse have been cloned recently. NTNRa was also termed GDNFRb, Ret ligand 2 （RETL2）or TGF-b-related neurotrophic factor receptor 2 （TrnR2） ａnd nominated as GFRa-2 recently. GFRa-2 binds NTN ａnd mediates activation of RET receptor tyrosine kinase by both NTN ａnd GDNF. Thus, NTN, GFRa-2, ａnd the Ret PTK form a complex to transduce NTN signal andto mediate NTN function.神经生物学相关蛋白（Neurobiology） 胶质细胞源性神经营养因子（GDNF）是TGF-β家族的一个新亚族，该亚族还有新发现的三个成员：Neurturin（NTN）、Persephin（PSP）和Artemin（ART），它们均不程度地对多巴胺神经元、脊髓前角运动神经元、背根神经节、颈上神经节以及肾等非神经元细胞都具有生长促进作用。研究表明胶质细胞系源性神经营养因子,主要用于PD的研究。GDNF的受体是多成分的复合物，它是由固定于质膜外层的糖基磷脂酰肌醇（GPI）被称为GDNFRα和酪氨酸激酶RET蛋白组成。GDNFRα为其配体结合亚单位，而RET则是GDNF的功能性受体亚单位，即GDNF特异地结合于其受体的GDNFRα上，再激活RET的酪氨酸磷酸化传导其信号，影响细胞的活性，发挥其生物学效应。目前，又克隆出了人与大鼠的GDNFRβ序列，与GDNPRα具有47％的同源性。GDNFRβ mRNA在脊髓、DRG和发育中的周围神经上也均有表达。

胶质细胞系源性神经营养因子受体α2抗体的质量标准：

■其它名称：	GDNF family receptor alpha 2; GDNF Receptor α2;GDNF receptor beta; GDNFR beta; GDNFRB; GFR
■交叉反应：	hu, mo, rat, cow, dog, hrs, chk
■产品类型：	一抗
■应用领域:	/发育生物学/神经生物学
■蛋白分子：	predicted molecular weight: 51kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human GDNF Receptor alpha 2 C-terminus
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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胶质细胞系源性神经营养因子受体α2抗体Anti-GDNF Receptor alpha 2的相关产品目录：







1mg/1ml 胶质细胞系源性神经营养因子受体α2抗体 Anti-GDNF Receptor alpha 2 GDNF family receptor alpha 2; GDNF Receptor α2;GDNF receptor beta; GDNFR beta; GDNFRB; GFR的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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