原癌基因WIP1抗体Anti-WIP1/PPM1DWPP-DOMAIN INTERACTING PROTEIN 1; EC 3.1.3.16; p53 induced protein phosphatase 1; PP2C del
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性能参数：

中文名称：原癌基因WIP1抗体
英文名称：Anti-WIP1/PPM1D
别名：WPP-DOMAIN INTERACTING PROTEIN 1; EC 3.1.3.16; p53 induced protein phosphatase 1; PP2C del
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：PPM1D （Wip） is a serine/threonine phosphatase implicated in cell cycle control, spermatogenesis, ａnd lymphoid cell function. The predicted 605-amino acid PPM1D protein contains 2 putative nuclear localization signals ａnd 3 regions conserved in serine/threonine PP2C phosphatases, as well as characteristics of a type 2C phosphatase, including magnesium dependence ａnd relative insensitivity to okadaic acid. PPM1D expression is induced in response to ionizing radiation in a p53-dependent manner. The accumulation of PPM1D mRNA following ionizing radiation is rapid ａnd transient, ａnd PPM1D protein is localized to the nucleus. PPM1D may contribute to growth inhibitory pathways activated in response to DNA damage in a p53-dependent manner. PPM1D inhibits phosphorylation of the p38 mitogen-activated （MAP）kinase protein. Through p38 MAPK, PPM1D modulates the CDKN2A tumor-suppressor locus. This gene is located in a chromosomal region known to be amplified in breast cancer, （located at 17q22-q23）, is amplified in human breast tumor cell lines ａnd in approximately 11% of primary breast tumors, ａnd appears to lead to cell transformation by abrogating p53 tumor suppressor activity. Inactivation of the p38 MAPK through PPM1D overexpression resulting from PPM1D amplification may contributes to the development of human cancers by suppressing p53 activation. PPM1D null mice have increased susceptibility to pathogens ａnd reduced male fertility ａnd longevity. Wip1是一种镁依赖性的丝氨酸/苏氨酸蛋白磷酸酶,属于蛋白磷酸酶2C家族。Wip1通过p53诱导在癌症的发生、发展中起到重要作用,在多种人类癌细胞中都已发现Wip1的大量扩增和过量存在。

原癌基因WIP1抗体的质量标准：

■其它名称：	WPP-DOMAIN INTERACTING PROTEIN 1; EC 3.1.3.16; p53 induced protein phosphatase 1; PP2C del
■交叉反应：	hu, mo, rat, pig, dog, chk, cow
■产品类型：	一抗
■应用领域:	/肿瘤/信号转导/细胞凋亡/激酶和磷酸酶
■蛋白分子：	predicted molecular weight: 67kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human WIP1 C-terminus
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//IF=1:100-500（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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质量投诉流程
1、向我们的客户服务部反应投诉原因及订单信息。
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友情提醒：
部分进口产品投诉须按照进口产品要求的检测方法提供证据。
由于化学产品的特殊性，恕不接受以下投诉：
1、超过质量投诉期的进口产品投诉
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原癌基因WIP1抗体Anti-WIP1/PPM1D的相关产品目录：







1mg/1ml 原癌基因WIP1抗体 Anti-WIP1/PPM1D WPP-DOMAIN INTERACTING PROTEIN 1; EC 3.1.3.16; p53 induced protein phosphatase 1; PP2C del的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

查询其它抗体目录请点击本公司化工仪器网链接：http://www.chem17.com/st233816/erlist_675408.html

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