肿瘤抑素抗体Anti-Tumstatin/COL4A3Collagen alpha-3（IV） chain; Alpha 3 type IV collagen; Alpha3 type IV collagen; COL4A 3; CO
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性能参数：

中文名称：肿瘤抑素抗体
英文名称：Anti-Tumstatin/COL4A3
别名：Collagen alpha-3（IV） chain; Alpha 3 type IV collagen; Alpha3 type IV collagen; COL4A 3; CO
包装号：G320
产地：中国大陆/进口产品
商标/品牌：Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商：田源试剂 TR、新试剂 NR
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产品详细描述

产品介绍：COL4A3 （Collagen, type IV, alpha 3） belongs to the type IV collagen family. Type IV collagen is the major structural component of glomerular basement membranes （GBM）, forming a ＇chicken-wire＇ meshwork together with laminins, proteoglycans ａnd entactin/nidogen. Type IV collagen is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. Tumstatin, a cleavage fragment corresponding to the collagen alpha 3（IV） NC1 domain, possesses both anti-angiogenic ａnd anti-tumor cell activity.Subcellular Location : Secreted, extracellular space, extracellular matrix, basement membrane. Note=Colocalizes with COL4A4 ａnd COL4A5 in GBM, tubular basement membrane （TBM） ａnd synaptic basal lamina（BL）.Tissue Specificity : Alpha 3 ａnd alpha 4 type IV collagens are colocalized ａnd present in kidney, eye, basement membranes of lens capsule, cochlea, lung, skeletal muscle, aorta, synaptic fibers, fetal kidney ａnd fetal lung. PubMed:8083201 reports similar levels of expression of alpha 3 ａnd alpha 4 type IV collagens in kidney, but PubMed:7523402 reports that in kidney levels of alpha 3 type IV collagen are significantly lower than those of alpha 4 type IV collagen. According to PubMed:8083201, alpha 3 type IV collagen is not detected in heart, brain, placenta, liver, pancreas, extrasynaptic muscle fibers, endoneurial ａnd perineurial nerves, fetal brain, fetal heart ａnd fetal liver. According to PubMed:7523402, alpha 3 type IV collagen is strongly expressed in pancreas, neuroretina ａnd calvaria ａnd not expressed in adrenal, ileum ａnd skin. Isoform 1 ａnd isoform 3 are strongly expressed in kidney, lung, suprarenal capsule, muscle ａnd spleen, in each of these tissues isoform 1 is more abundant than isoform 3. Isoform 1 ａnd isoform 3 are expressed at low levels in artery, fat, pericardium ａnd peripherical nerve, but not in placenta, mesangium, skin, pleura ａnd cultured umbilical endothelial cells.Similarity : Belongs to the type IV collagen family.Contains 1 collagen IV NC1 （C-terminal non-collagenous） domain.Subunit : here are six type IV collagen isoforms, alpha 1（IV）-alpha 6（IV）, each of which can form a triple helix structure with 2 other chains to generate type IV collagen network. The alpha 3（IV） chain forms a triple helical protomer with alpha 4（IV） ａnd alpha 5（IV）; this triple helical structure dimerizes through NC1-NC1 domain interactions such that the alpha 3（IV）, alpha 4（IV） ａnd alpha 5（IV） chains of one protomer connect with the alpha 5（IV）, alpha 4（IV） ａnd alpha 3（IV） chains of the opposite promoter, respectively. Interacts with COL4A3BP AND ITGB3. Associates with LAMB2 at the neuromuscular junction ａnd in GBM.肿瘤抑素（Tumstatin）是来源于血管基底膜Ⅳ型胶原的肿瘤血管生成抑制因子，一种自然产生的大分子多肽蛋白，特异性结合αvβ3整合素受体选择性抑制肿瘤血管内皮细胞的增殖和迁移，能够抑制原始血管外生长出新的血管，从而抑制肿瘤生长、增值，肿瘤抑素具有很强的生物学效应。

肿瘤抑素抗体的质量标准：

■其它名称：	Collagen alpha-3（IV） chain; Alpha 3 type IV collagen; Alpha3 type IV collagen; COL4A 3; CO
■交叉反应：	hu, mo, rat
■产品类型：	一抗
■应用领域:	/肿瘤/胶原蛋白
■蛋白分子：	predicted molecular weight: 162kDa
■浓度值：	1mg/1ml
■物理性状：	Lyophilized or Liquid
■免疫原：	KLH conjugated synthetic peptide derived from human Tumstatin C-terminus
■亚型：	polyclonal
■纯化方法：	affinity purified by Protein A
■保存液：	0.01M PBS, pH 7.4 with 10 mg/ml BSA ａnd 0.1% Sodium azide
■应用技术：	//WB=1:200-1000//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-600//IHC-F=1:100-600//IF=1:100-600（石蜡切片需做抗原修复）/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user.
■保存环境：	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month ａnd for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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肿瘤抑素抗体Anti-Tumstatin/COL4A3的相关产品目录：







1mg/1ml 肿瘤抑素抗体 Anti-Tumstatin/COL4A3 Collagen alpha-3（IV） chain; Alpha 3 type IV collagen; Alpha3 type IV collagen; COL4A 3; CO的来源为Rabbit，其相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗

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