产品展示
Klotho多肽蛋白抗体 田源一抗
点击次数:242发布时间:2012/8/15 20:47:40
更新日期:2013/6/26 15:26:02
所 在 地:其它
产品型号:Anti-Klotho
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详细内容
Klotho多肽蛋白抗体Anti-KlothoKL antibody KLOT_HUMAN; Klotho peptide.
360TIYO.COM-上海田源公司
性能参数:
中文名称:Klotho多肽蛋白抗体
英文名称:Anti-Klotho
别名:KL antibody KLOT_HUMAN; Klotho peptide.
包装号:G320
产地:中国大陆/进口产品
商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology
供应商:田源试剂 TR、新试剂 NR
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产品详细描述
产品介绍:May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1.The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling.Subcellular Location : Isoform 1: Cell membrane; Single-pass type I membrane protein. Note=Isoform 1 shedding leads to a soluble peptide. Isoform 2: Secreted. Klotho peptide: Secreted.Tissue Specificity : Present in cortical renal tubules (at protein level). Soluble peptide is present in serum and cerebrospinal fluid. Expressed in kidney, placenta, small intestine and prostate. Down-regulated in renal cell carcinomas, hepatocellular carcinomas, and in chronic renal failure kidney.Similarity : Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.Klotho多肽蛋白抗体的质量标准:
■其它名称: | KL antibody KLOT_HUMAN; Klotho peptide. |
■交叉反应: | hu, mo, rat, Rb, cow, hrs, pig, dog |
■产品类型: | 一抗 |
■应用领域: | /免疫学/发育生物学/信号转导 |
■蛋白分子: | predicted molecular weight: 111kDa |
■浓度值: | 1mg/1ml |
■物理性状: | Lyophilized or Liquid |
■免疫原: | KLH conjugated synthetic peptide derived from human Klotho |
■亚型: | polyclonal |
■纯化方法: | affinity purified by Protein A |
■保存液: | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
■应用技术: | //WB=1:100-500//ELISA=1:500-1000//IP=1:20-100//IHC-P=1:100-500//IHC-F=1:100-500//Flow-Cyt=1:100-500//IF=1:100-500(石蜡切片需做抗原修复)/not yet tested in other applications./optimal dilutions/concentrations should be determined by the end user. |
■保存环境: | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
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Klotho多肽蛋白抗体Anti-Klotho的相关产品目录:
1mg/1ml Klotho多肽蛋白抗体 Anti-Klotho KL antibody KLOT_HUMAN; Klotho peptide.的来源为Rabbit,其相关产品:免疫组化常用试剂免疫印迹常用试剂各种标记二抗
查询其它抗体目录请点击本公司化工仪器网链接:http://www.chem17.com/st233816/erlist_675408.html
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