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PRO-337 B2M Human Recombinant/重组人Beta-2微球蛋白
点击次数：195发布时间：2012/7/18 10:36:17
更新日期：2024/10/16 15:58:55
所 在 地：美洲
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厦门慧嘉生物专业销售PRO-337 B2M Human Recombinant/重组人Beta-2微球蛋白 Santa Abcam Cst jackson Pierce Sigma Amresco Qiagen Cayman abnova millipore invitrogen merk ebioscience prospec peprotech细胞因子特价。等生物试剂产品。实验为大，诚信经营，为客户提供“质量的产品”和“质的服务"QQ: 1193953234 1048735792 或登陆（向客服人员索取原版说明书） http://www.biohj.com 欢迎广大老师来询！
B2M Human Recombinant/重组人Beta-2微球蛋白
产品编号：PRO-337
产品规格：10μg/50μg/1mg
产品规格：10μg/50μg/1mg
| Synonyms | Beta-2-microglobulin, B2M. |
| Introduction | ?2 microglobulin is an 11 kDa protein associated with the outer membrane of many cells including lymphocytes. It is the small subunit of the MHC class I molecule. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. ?2 microglobulin associates with class I-like molecules such as CD1 ａnd Qa as well as with the alpha chain of MHC class I molecules. Very limited amounts of MHC class I molecules can be found on the surface in the absence of ?2 microglobulin. CD8 T cells cannot develop in the absence of MHC class I. Beta 2-microglobulin is present in small amounts in serum, csf, ａnd urine of normal people, ａnd to a much greater degree in the urine ａnd plasma of patients with tubular proteinaemia, renal failure, or kidney transplants. Human Beta 2 microglobulin levels can rise either because its rate of synthesis has increased （e.g. in AIDS, malignant monoclonal plasma cell dyscrasia, solid tumors ａnd autoimmune disease） or because of impaired renal filtration （e.g. due to renal insufficiency, graft rejection or nephrotoxicity induced by post-transplantation immunosuppressive therapy）. Beta-2 microglobulin levels might also be elevated in multiple myeloma ａnd lymphoma cases. Dialysis-related amyloidosis develops after a long-term hemodialysis, it can aggregate into amyloid fibers that deposit in joint spaces. |
| Description | B2 Microglobulin Human Recombinant produced in E.Coli is a non-glycosylated polypeptide chain having a molecular mass of 11.76 kDa. The B2M is purified by proprietary chromatographic techniques. |
| Source | Escherichia Coli. |
| Physical Appearance | Sterile Filtered White lyophilized （freeze-dried） powder. |
| Formulation | The protein was lyophilized from a concentrated solution （1mg/ml） containing PBS （pH 7.4） ａnd 0.05% NaN3. |
| Solubility | It is recommended to reconstitute the lyophilized B2M in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. |
| Stability | Lyophilized B2M although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution B2M should be stored at 4°C between 2-7 days ａnd for future use below -18°C. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles. |
| Purity | Greater than 95.0% as determined by（a） Analysis by RP-HPLC. （b） Analysis by SDS-PAGE. |
| Usage | Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
