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PRO-553 B2M Human/人Beta-2微球蛋白
点击次数：226发布时间：2012/7/18 10:50:45
更新日期：2024/10/16 15:58:55
所 在 地：美洲
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厦门慧嘉生物专业销售PRO-553 B2M Human/人Beta-2微球蛋白 Santa Abcam Cst jackson Pierce Sigma Amresco Qiagen Cayman abnova millipore invitrogen merk ebioscience prospec peprotech细胞因子特价。等生物试剂产品。实验为大，诚信经营，为客户提供“质量的产品”和“质的服务"QQ: 1193953234 1048735792 或登陆（向客服人员索取原版说明书） http://www.biohj.com 欢迎广大老师来询！
B2M Human/人Beta-2微球蛋白
产品编号：PRO-553
产品规格：200μg/1mg/10mg
产品规格：200μg/1mg/10mg
| Synonyms | Beta-2-microglobulin, B2M. |
| Introduction | ?2 microglobulin is an 11 kDa protein associated with the outer membrane of many cells including lymphocytes. It is the small subunit of the MHC class I molecule. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. ?2 microglobulin associates with class I-like molecules such as CD1 ａnd Qa as well as with the alpha chain of MHC class I molecules. Very limited amounts of MHC class I molecules can be found on the surface in the absence of ?2 microglobulin. CD8 T cells cannot develop in the absence of MHC class I. Beta 2-microglobulin is present in small amounts in serum, csf, ａnd urine of normal people, ａnd to a much greater degree in the urine ａnd plasma of patients with tubular proteinaemia, renal failure, or kidney transplants. Human Beta 2 microglobulin levels can rise either because its rate of synthesis has increased （e.g. in AIDS, malignant monoclonal plasma cell dyscrasia, solid tumors ａnd autoimmune disease） or because of impaired renal filtration （e.g. due to renal insufficiency, graft rejection or nephrotoxicity induced by post-transplantation immunosuppressive therapy）. Beta-2 microglobulin levels might also be elevated in multiple myeloma ａnd lymphoma cases. Dialysis-related amyloidosis develops after a long-term hemodialysis, it can aggregate into amyloid fibers that deposit in joint spaces. |
| Description | Human Beta-2 Microglobulin produced in Human urine from patients with tubular proteinuria having a molecular mass of 12KDa ａnd pI of 5.6. |
| Source | Human urine from patients with tubular proteinuria. |
| Physical Appearance | Sterile Filtered White lyophilized （freeze-dried） powder. |
| Formulation | Lyophilized from 0.02M NH4HCO3. |
| Solubility | It is recommended to reconstitute the lyophilized HuB2M in phosphate buffer pH > 7.0 containing 0.15M NaCl. |
| Stability | Human B2M although stable at room temperature for 3 weeks, should be stored between 2-8°C. |
| Purity | Greater than 98.0%. |
| Human Virus Test | Starting material tested ａnd found negative for HIV I & II antibodies, Hepatitis B surface antigen, ａnd Hepatitis C antibodies. Finished product tested ａnd found negative for HIV antigen P24. |
| Usage | Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
