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PRO-781 Pleckstrin homology-like domain family A member 2 Human Recombinant

点击次数:233发布时间:2012/7/19 14:28:59

PRO-781 Pleckstrin homology-like domain family A member 2 Human Recombinant

更新日期:2024/10/16 15:58:55

所 在 地:美洲

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简单介绍:厦门慧嘉生物长期专业销售PRO-781 Pleckstrin homology-like domain family A member 2 Human Recombinant \Santa\Abcam\ Cst\jackson\Pierce\Sigma\Amresco\Qiagen\Cayman \abnova\millipore\invitrogen\merk\ebioscience\prospec\peprotech细胞因子特价专供

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厦门慧嘉生物专业销售PRO-781 Pleckstrin homology-like domain family A member 2 Human Recombinant   Santa  Abcam  Cst   jackson    Pierce  Sigma    Amresco   Qiagen     Cayman    abnova    millipore   invitrogen  merk     ebioscience    prospec    peprotech细胞因子特价。等生物试剂产品。实验为大,诚信经营,为客户提供“质量的产品”和“质的服务"QQ: 1193953234 1048735792 或登陆(向客服人员索取原版说明书) http://www.biohj.com 欢迎广大老师来询!
 
 

Pleckstrin homology-like domain family A member 2 Human Recombinant

产品编号:PRO-781
产品规格:2μg/10μg/1mg
 
 

Synonyms

Pleckstrin homology-like domain family A member 2, Imprinted in placenta and liver protein, Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein, Tumor-suppressing STF cDNA 3 protein, Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein, p17-Beckwith-Wiedemann region 1 C, PHLDA2, BWR1C, HLDA2, IPL, TSSC3, BRW1C.

Introduction

Pleckstrin homology-like domain family A member 2 (PHLDA2) is a cytoplasmic protein, which is involved in fetal and placental growth. PHLDA2 is an apoptosis-related protein, which acts as a negative growth regulator and is expressed during normal human development. PHLDA2 is imprinted on placenta, liver and fetal tissues during embryogenesis and is removed once development is complete. The PHLDA2 gene is one of a number of genes in the imprinted gene domain of 11p15.5 which is considered to be an important tumor suppressor gene region. Changes in this region may be linked to the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. PHLDA2 is expressed in placenta (present in all cells of the villous cytotrophoblast) and adult prostate gland. Furthermore, PHLDA2 is expressed in adult brain and neuroblastoma, medullablastoma and glioblastoma cell lines and at low levels in adult liver and lung, and fetal liver.

Description

PHLDA2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 172 amino acids (1-152 a.a.) and having a molecular mass of 19.2 kDa. PHLDA2 is fused to 20 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile filtered colorless solution.

Formulation

PHLDA2 solution containing 20mM Tris-HCl buffer (pH8.0), 20% glycerol 0.1M NaCl and 1mM DTT.

Stability

PHLDA2 Human Recombinant although stable at 4°C for 1 week, should be stored below -18°C. Please prevent freeze thaw cycles.

Purity

Greater than 80% as determined by SDS-PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MKSPDEVLRE GELEKRSDSL FQLWKKKRGV LTSDRLSLFP ASPRARPKEL RFHSILKVDC VERTGKYVYF TIVTTDHKEI DFRCAGESCW NAAIALALID FQNRRALQDF RSRQERTAPA APAEDAVAAA AAAPSEPSEP SRPSPQPKPR TP.

Usage

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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