产品展示
PRO-604 Angiostatin K1-4/重组人血管抑素 Kringles 1-4
点击次数：179发布时间：2012/7/23 16:01:23
更新日期：2024/10/16 15:58:55
所 在 地：美洲
产品型号：
优质供应
详细内容
厦门慧嘉生物专业销售PRO-604 Angiostatin K1-4/重组人血管抑素 Kringles 1-4 Santa Abcam Cst jackson Pierce Sigma Amresco Qiagen Cayman abnova millipore invitrogen merk ebioscience prospec peprotech细胞因子特价。等生物试剂产品。实验为大，诚信经营，为客户提供“质量的产品”和“质的服务"QQ: 1193953234 1048735792 或登陆（向客服人员索取原版说明书） http://www.biohj.com 欢迎广大老师来询！
Angiostatin K1-4/重组人血管抑素 Kringles 1-4
产品编号：PRO-604
产品规格：2μg/10μg/1mg
Introduction There are several proteolytic fragments or specific domains of proteins that act as inhibitors of angiogenesis. These include fragments of plasminogen such as Angiostatin protein kringles 1-4 ａnd kringles 1-5, Endostatin, Restin, PEX, the N-terminal fragment of prolactin, ａnd the Nterminally truncated platelet factor. Angiostatin is a proteolytic protein fragment of plasminogen that is comprised of the first 4 kringle regions. Angiostatin k1-4 prevents the growth of endothelial cells, ａnd its systemic administration inhibits the growth of primary carcinomas in mice. Angiostatin Kringles 1-3 segment has a larger inhibitory activity than the Angiostatin kringles 1-4 fragment. The protease-activated angiostatin kringles 1-5 is the most potent plasminogen fragment with over 50 times larger endothelial cell specific inhibitory activity. Angiostatin kringles 1-5 systemic administration inhibits growth of fibrosarcoma ａnd significantly reduces neovascularization.
Angiostatin is an angiogenesis inhibitor in mouse serum ａnd urine. Angiostatin is a 38 kDa protein fragment of the plasminogen composed of the 1st 4 kringle domains of plasminogen. Angiostatin K1-4 is also named plasminogen kringles 1-4 ａnd PK1-4.
Angiostatin protein is manufactured by the protelytic cleavage of plasminogen by a serine protease from several prostate carcinoma cell lines. The manufacturing of angiostatin by pancreatic cancer cells can be inhibited by TGF-beta 1 along with plasminogen activator inhibitor type-1 （PAI1）. Description Human Angiostatin kringles 1-4 is produced from Human Fluid is a glycosylated polypeptide chain which migrates as a doublet 50 kDa on SDS-PAGE.
The Ang K1-4 is purified by proprietary chromatographic techniques. Source Human Fluid. Physical Appearance Sterile Filtered lyophilized powder. Formulation Lyophilized from a （1mg/ml） solution in containing 20mM Hepes buffer pH-8.2 & 20mM NaCl. Solubility It is recommended to reconstitute the lyophilized Angiostatin K1-4 in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized Angiostatin Kringles 1-4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Angiostatin Kringles1-4 should be stored at 4°C between 2-7 days ａnd for future use below -18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Purity Greater than 98.0% as determined by SDS-PAGE. Biological Activity Human Angiostatin Kringles 1-4 significantly inhibits basic-FGF induced endothelial cell proliferation ａnd migration at concentration ranging from 300nM-1.0 uM. Usage ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Angiostatin K1-4/重组人血管抑素 Kringles 1-4
产品编号：PRO-604
产品规格：2μg/10μg/1mg
Introduction There are several proteolytic fragments or specific domains of proteins that act as inhibitors of angiogenesis. These include fragments of plasminogen such as Angiostatin protein kringles 1-4 ａnd kringles 1-5, Endostatin, Restin, PEX, the N-terminal fragment of prolactin, ａnd the Nterminally truncated platelet factor. Angiostatin is a proteolytic protein fragment of plasminogen that is comprised of the first 4 kringle regions. Angiostatin k1-4 prevents the growth of endothelial cells, ａnd its systemic administration inhibits the growth of primary carcinomas in mice. Angiostatin Kringles 1-3 segment has a larger inhibitory activity than the Angiostatin kringles 1-4 fragment. The protease-activated angiostatin kringles 1-5 is the most potent plasminogen fragment with over 50 times larger endothelial cell specific inhibitory activity. Angiostatin kringles 1-5 systemic administration inhibits growth of fibrosarcoma ａnd significantly reduces neovascularization.
Angiostatin is an angiogenesis inhibitor in mouse serum ａnd urine. Angiostatin is a 38 kDa protein fragment of the plasminogen composed of the 1st 4 kringle domains of plasminogen. Angiostatin K1-4 is also named plasminogen kringles 1-4 ａnd PK1-4.
Angiostatin protein is manufactured by the protelytic cleavage of plasminogen by a serine protease from several prostate carcinoma cell lines. The manufacturing of angiostatin by pancreatic cancer cells can be inhibited by TGF-beta 1 along with plasminogen activator inhibitor type-1 （PAI1）. Description Human Angiostatin kringles 1-4 is produced from Human Fluid is a glycosylated polypeptide chain which migrates as a doublet 50 kDa on SDS-PAGE.
The Ang K1-4 is purified by proprietary chromatographic techniques. Source Human Fluid. Physical Appearance Sterile Filtered lyophilized powder. Formulation Lyophilized from a （1mg/ml） solution in containing 20mM Hepes buffer pH-8.2 & 20mM NaCl. Solubility It is recommended to reconstitute the lyophilized Angiostatin K1-4 in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized Angiostatin Kringles 1-4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Angiostatin Kringles1-4 should be stored at 4°C between 2-7 days ａnd for future use below -18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Purity Greater than 98.0% as determined by SDS-PAGE. Biological Activity Human Angiostatin Kringles 1-4 significantly inhibits basic-FGF induced endothelial cell proliferation ａnd migration at concentration ranging from 300nM-1.0 uM. Usage ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Angiostatin K1-4/重组人血管抑素 Kringles 1-4
产品编号：PRO-604
产品规格：2μg/10μg/1mg
Introduction There are several proteolytic fragments or specific domains of proteins that act as inhibitors of angiogenesis. These include fragments of plasminogen such as Angiostatin protein kringles 1-4 ａnd kringles 1-5, Endostatin, Restin, PEX, the N-terminal fragment of prolactin, ａnd the Nterminally truncated platelet factor. Angiostatin is a proteolytic protein fragment of plasminogen that is comprised of the first 4 kringle regions. Angiostatin k1-4 prevents the growth of endothelial cells, ａnd its systemic administration inhibits the growth of primary carcinomas in mice. Angiostatin Kringles 1-3 segment has a larger inhibitory activity than the Angiostatin kringles 1-4 fragment. The protease-activated angiostatin kringles 1-5 is the most potent plasminogen fragment with over 50 times larger endothelial cell specific inhibitory activity. Angiostatin kringles 1-5 systemic administration inhibits growth of fibrosarcoma ａnd significantly reduces neovascularization.
Angiostatin is an angiogenesis inhibitor in mouse serum ａnd urine. Angiostatin is a 38 kDa protein fragment of the plasminogen composed of the 1st 4 kringle domains of plasminogen. Angiostatin K1-4 is also named plasminogen kringles 1-4 ａnd PK1-4.
Angiostatin protein is manufactured by the protelytic cleavage of plasminogen by a serine protease from several prostate carcinoma cell lines. The manufacturing of angiostatin by pancreatic cancer cells can be inhibited by TGF-beta 1 along with plasminogen activator inhibitor type-1 （PAI1）. Description Human Angiostatin kringles 1-4 is produced from Human Fluid is a glycosylated polypeptide chain which migrates as a doublet 50 kDa on SDS-PAGE.
The Ang K1-4 is purified by proprietary chromatographic techniques. Source Human Fluid. Physical Appearance Sterile Filtered lyophilized powder. Formulation Lyophilized from a （1mg/ml） solution in containing 20mM Hepes buffer pH-8.2 & 20mM NaCl. Solubility It is recommended to reconstitute the lyophilized Angiostatin K1-4 in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized Angiostatin Kringles 1-4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Angiostatin Kringles1-4 should be stored at 4°C between 2-7 days ａnd for future use below -18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Purity Greater than 98.0% as determined by SDS-PAGE. Biological Activity Human Angiostatin Kringles 1-4 significantly inhibits basic-FGF induced endothelial cell proliferation ａnd migration at concentration ranging from 300nM-1.0 uM. Usage ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Angiostatin K1-4/重组人血管抑素 Kringles 1-4
产品编号：PRO-604
产品规格：2μg/10μg/1mg
Introduction There are several proteolytic fragments or specific domains of proteins that act as inhibitors of angiogenesis. These include fragments of plasminogen such as Angiostatin protein kringles 1-4 ａnd kringles 1-5, Endostatin, Restin, PEX, the N-terminal fragment of prolactin, ａnd the Nterminally truncated platelet factor. Angiostatin is a proteolytic protein fragment of plasminogen that is comprised of the first 4 kringle regions. Angiostatin k1-4 prevents the growth of endothelial cells, ａnd its systemic administration inhibits the growth of primary carcinomas in mice. Angiostatin Kringles 1-3 segment has a larger inhibitory activity than the Angiostatin kringles 1-4 fragment. The protease-activated angiostatin kringles 1-5 is the most potent plasminogen fragment with over 50 times larger endothelial cell specific inhibitory activity. Angiostatin kringles 1-5 systemic administration inhibits growth of fibrosarcoma ａnd significantly reduces neovascularization.
Angiostatin is an angiogenesis inhibitor in mouse serum ａnd urine. Angiostatin is a 38 kDa protein fragment of the plasminogen composed of the 1st 4 kringle domains of plasminogen. Angiostatin K1-4 is also named plasminogen kringles 1-4 ａnd PK1-4.
Angiostatin protein is manufactured by the protelytic cleavage of plasminogen by a serine protease from several prostate carcinoma cell lines. The manufacturing of angiostatin by pancreatic cancer cells can be inhibited by TGF-beta 1 along with plasminogen activator inhibitor type-1 （PAI1）. Description Human Angiostatin kringles 1-4 is produced from Human Fluid is a glycosylated polypeptide chain which migrates as a doublet 50 kDa on SDS-PAGE.
The Ang K1-4 is purified by proprietary chromatographic techniques. Source Human Fluid. Physical Appearance Sterile Filtered lyophilized powder. Formulation Lyophilized from a （1mg/ml） solution in containing 20mM Hepes buffer pH-8.2 & 20mM NaCl. Solubility It is recommended to reconstitute the lyophilized Angiostatin K1-4 in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized Angiostatin Kringles 1-4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Angiostatin Kringles1-4 should be stored at 4°C between 2-7 days ａnd for future use below -18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Purity Greater than 98.0% as determined by SDS-PAGE. Biological Activity Human Angiostatin Kringles 1-4 significantly inhibits basic-FGF induced endothelial cell proliferation ａnd migration at concentration ranging from 300nM-1.0 uM. Usage ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Angiostatin K1-4/重组人血管抑素 Kringles 1-4
产品编号：PRO-604
产品规格：2μg/10μg/1mg
Introduction There are several proteolytic fragments or specific domains of proteins that act as inhibitors of angiogenesis. These include fragments of plasminogen such as Angiostatin protein kringles 1-4 ａnd kringles 1-5, Endostatin, Restin, PEX, the N-terminal fragment of prolactin, ａnd the Nterminally truncated platelet factor. Angiostatin is a proteolytic protein fragment of plasminogen that is comprised of the first 4 kringle regions. Angiostatin k1-4 prevents the growth of endothelial cells, ａnd its systemic administration inhibits the growth of primary carcinomas in mice. Angiostatin Kringles 1-3 segment has a larger inhibitory activity than the Angiostatin kringles 1-4 fragment. The protease-activated angiostatin kringles 1-5 is the most potent plasminogen fragment with over 50 times larger endothelial cell specific inhibitory activity. Angiostatin kringles 1-5 systemic administration inhibits growth of fibrosarcoma ａnd significantly reduces neovascularization.
Angiostatin is an angiogenesis inhibitor in mouse serum ａnd urine. Angiostatin is a 38 kDa protein fragment of the plasminogen composed of the 1st 4 kringle domains of plasminogen. Angiostatin K1-4 is also named plasminogen kringles 1-4 ａnd PK1-4.
Angiostatin protein is manufactured by the protelytic cleavage of plasminogen by a serine protease from several prostate carcinoma cell lines. The manufacturing of angiostatin by pancreatic cancer cells can be inhibited by TGF-beta 1 along with plasminogen activator inhibitor type-1 （PAI1）. Description Human Angiostatin kringles 1-4 is produced from Human Fluid is a glycosylated polypeptide chain which migrates as a doublet 50 kDa on SDS-PAGE.
The Ang K1-4 is purified by proprietary chromatographic techniques. Source Human Fluid. Physical Appearance Sterile Filtered lyophilized powder. Formulation Lyophilized from a （1mg/ml） solution in containing 20mM Hepes buffer pH-8.2 & 20mM NaCl. Solubility It is recommended to reconstitute the lyophilized Angiostatin K1-4 in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized Angiostatin Kringles 1-4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Angiostatin Kringles1-4 should be stored at 4°C between 2-7 days ａnd for future use below -18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Purity Greater than 98.0% as determined by SDS-PAGE. Biological Activity Human Angiostatin Kringles 1-4 significantly inhibits basic-FGF induced endothelial cell proliferation ａnd migration at concentration ranging from 300nM-1.0 uM. Usage ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Angiostatin K1-4/重组人血管抑素 Kringles 1-4
产品编号：PRO-604
产品规格：2μg/10μg/1mg
Introduction There are several proteolytic fragments or specific domains of proteins that act as inhibitors of angiogenesis. These include fragments of plasminogen such as Angiostatin protein kringles 1-4 ａnd kringles 1-5, Endostatin, Restin, PEX, the N-terminal fragment of prolactin, ａnd the Nterminally truncated platelet factor. Angiostatin is a proteolytic protein fragment of plasminogen that is comprised of the first 4 kringle regions. Angiostatin k1-4 prevents the growth of endothelial cells, ａnd its systemic administration inhibits the growth of primary carcinomas in mice. Angiostatin Kringles 1-3 segment has a larger inhibitory activity than the Angiostatin kringles 1-4 fragment. The protease-activated angiostatin kringles 1-5 is the most potent plasminogen fragment with over 50 times larger endothelial cell specific inhibitory activity. Angiostatin kringles 1-5 systemic administration inhibits growth of fibrosarcoma ａnd significantly reduces neovascularization.
Angiostatin is an angiogenesis inhibitor in mouse serum ａnd urine. Angiostatin is a 38 kDa protein fragment of the plasminogen composed of the 1st 4 kringle domains of plasminogen. Angiostatin K1-4 is also named plasminogen kringles 1-4 ａnd PK1-4.
Angiostatin protein is manufactured by the protelytic cleavage of plasminogen by a serine protease from several prostate carcinoma cell lines. The manufacturing of angiostatin by pancreatic cancer cells can be inhibited by TGF-beta 1 along with plasminogen activator inhibitor type-1 （PAI1）. Description Human Angiostatin kringles 1-4 is produced from Human Fluid is a glycosylated polypeptide chain which migrates as a doublet 50 kDa on SDS-PAGE.
The Ang K1-4 is purified by proprietary chromatographic techniques. Source Human Fluid. Physical Appearance Sterile Filtered lyophilized powder. Formulation Lyophilized from a （1mg/ml） solution in containing 20mM Hepes buffer pH-8.2 & 20mM NaCl. Solubility It is recommended to reconstitute the lyophilized Angiostatin K1-4 in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized Angiostatin Kringles 1-4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Angiostatin Kringles1-4 should be stored at 4°C between 2-7 days ａnd for future use below -18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Purity Greater than 98.0% as determined by SDS-PAGE. Biological Activity Human Angiostatin Kringles 1-4 significantly inhibits basic-FGF induced endothelial cell proliferation ａnd migration at concentration ranging from 300nM-1.0 uM. Usage ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Angiostatin K1-4/重组人血管抑素 Kringles 1-4
产品编号：PRO-604
产品规格：2μg/10μg/1mg
Introduction There are several proteolytic fragments or specific domains of proteins that act as inhibitors of angiogenesis. These include fragments of plasminogen such as Angiostatin protein kringles 1-4 ａnd kringles 1-5, Endostatin, Restin, PEX, the N-terminal fragment of prolactin, ａnd the Nterminally truncated platelet factor. Angiostatin is a proteolytic protein fragment of plasminogen that is comprised of the first 4 kringle regions. Angiostatin k1-4 prevents the growth of endothelial cells, ａnd its systemic administration inhibits the growth of primary carcinomas in mice. Angiostatin Kringles 1-3 segment has a larger inhibitory activity than the Angiostatin kringles 1-4 fragment. The protease-activated angiostatin kringles 1-5 is the most potent plasminogen fragment with over 50 times larger endothelial cell specific inhibitory activity. Angiostatin kringles 1-5 systemic administration inhibits growth of fibrosarcoma ａnd significantly reduces neovascularization.
Angiostatin is an angiogenesis inhibitor in mouse serum ａnd urine. Angiostatin is a 38 kDa protein fragment of the plasminogen composed of the 1st 4 kringle domains of plasminogen. Angiostatin K1-4 is also named plasminogen kringles 1-4 ａnd PK1-4.
Angiostatin protein is manufactured by the protelytic cleavage of plasminogen by a serine protease from several prostate carcinoma cell lines. The manufacturing of angiostatin by pancreatic cancer cells can be inhibited by TGF-beta 1 along with plasminogen activator inhibitor type-1 （PAI1）. Description Human Angiostatin kringles 1-4 is produced from Human Fluid is a glycosylated polypeptide chain which migrates as a doublet 50 kDa on SDS-PAGE.
The Ang K1-4 is purified by proprietary chromatographic techniques. Source Human Fluid. Physical Appearance Sterile Filtered lyophilized powder. Formulation Lyophilized from a （1mg/ml） solution in containing 20mM Hepes buffer pH-8.2 & 20mM NaCl. Solubility It is recommended to reconstitute the lyophilized Angiostatin K1-4 in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized Angiostatin Kringles 1-4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Angiostatin Kringles1-4 should be stored at 4°C between 2-7 days ａnd for future use below -18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Purity Greater than 98.0% as determined by SDS-PAGE. Biological Activity Human Angiostatin Kringles 1-4 significantly inhibits basic-FGF induced endothelial cell proliferation ａnd migration at concentration ranging from 300nM-1.0 uM. Usage ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Angiostatin K1-4/重组人血管抑素 Kringles 1-4
产品编号：PRO-604
产品规格：2μg/10μg/1mg
Introduction There are several proteolytic fragments or specific domains of proteins that act as inhibitors of angiogenesis. These include fragments of plasminogen such as Angiostatin protein kringles 1-4 ａnd kringles 1-5, Endostatin, Restin, PEX, the N-terminal fragment of prolactin, ａnd the Nterminally truncated platelet factor. Angiostatin is a proteolytic protein fragment of plasminogen that is comprised of the first 4 kringle regions. Angiostatin k1-4 prevents the growth of endothelial cells, ａnd its systemic administration inhibits the growth of primary carcinomas in mice. Angiostatin Kringles 1-3 segment has a larger inhibitory activity than the Angiostatin kringles 1-4 fragment. The protease-activated angiostatin kringles 1-5 is the most potent plasminogen fragment with over 50 times larger endothelial cell specific inhibitory activity. Angiostatin kringles 1-5 systemic administration inhibits growth of fibrosarcoma ａnd significantly reduces neovascularization.
Angiostatin is an angiogenesis inhibitor in mouse serum ａnd urine. Angiostatin is a 38 kDa protein fragment of the plasminogen composed of the 1st 4 kringle domains of plasminogen. Angiostatin K1-4 is also named plasminogen kringles 1-4 ａnd PK1-4.
Angiostatin protein is manufactured by the protelytic cleavage of plasminogen by a serine protease from several prostate carcinoma cell lines. The manufacturing of angiostatin by pancreatic cancer cells can be inhibited by TGF-beta 1 along with plasminogen activator inhibitor type-1 （PAI1）. Description Human Angiostatin kringles 1-4 is produced from Human Fluid is a glycosylated polypeptide chain which migrates as a doublet 50 kDa on SDS-PAGE.
The Ang K1-4 is purified by proprietary chromatographic techniques. Source Human Fluid. Physical Appearance Sterile Filtered lyophilized powder. Formulation Lyophilized from a （1mg/ml） solution in containing 20mM Hepes buffer pH-8.2 & 20mM NaCl. Solubility It is recommended to reconstitute the lyophilized Angiostatin K1-4 in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized Angiostatin Kringles 1-4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Angiostatin Kringles1-4 should be stored at 4°C between 2-7 days ａnd for future use below -18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Purity Greater than 98.0% as determined by SDS-PAGE. Biological Activity Human Angiostatin Kringles 1-4 significantly inhibits basic-FGF induced endothelial cell proliferation ａnd migration at concentration ranging from 300nM-1.0 uM. Usage ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Angiostatin K1-4/重组人血管抑素 Kringles 1-4
产品编号：PRO-604
产品规格：2μg/10μg/1mg
Introduction There are several proteolytic fragments or specific domains of proteins that act as inhibitors of angiogenesis. These include fragments of plasminogen such as Angiostatin protein kringles 1-4 ａnd kringles 1-5, Endostatin, Restin, PEX, the N-terminal fragment of prolactin, ａnd the Nterminally truncated platelet factor. Angiostatin is a proteolytic protein fragment of plasminogen that is comprised of the first 4 kringle regions. Angiostatin k1-4 prevents the growth of endothelial cells, ａnd its systemic administration inhibits the growth of primary carcinomas in mice. Angiostatin Kringles 1-3 segment has a larger inhibitory activity than the Angiostatin kringles 1-4 fragment. The protease-activated angiostatin kringles 1-5 is the most potent plasminogen fragment with over 50 times larger endothelial cell specific inhibitory activity. Angiostatin kringles 1-5 systemic administration inhibits growth of fibrosarcoma ａnd significantly reduces neovascularization.
Angiostatin is an angiogenesis inhibitor in mouse serum ａnd urine. Angiostatin is a 38 kDa protein fragment of the plasminogen composed of the 1st 4 kringle domains of plasminogen. Angiostatin K1-4 is also named plasminogen kringles 1-4 ａnd PK1-4.
Angiostatin protein is manufactured by the protelytic cleavage of plasminogen by a serine protease from several prostate carcinoma cell lines. The manufacturing of angiostatin by pancreatic cancer cells can be inhibited by TGF-beta 1 along with plasminogen activator inhibitor type-1 （PAI1）. Description Human Angiostatin kringles 1-4 is produced from Human Fluid is a glycosylated polypeptide chain which migrates as a doublet 50 kDa on SDS-PAGE.
The Ang K1-4 is purified by proprietary chromatographic techniques. Source Human Fluid. Physical Appearance Sterile Filtered lyophilized powder. Formulation Lyophilized from a （1mg/ml） solution in containing 20mM Hepes buffer pH-8.2 & 20mM NaCl. Solubility It is recommended to reconstitute the lyophilized Angiostatin K1-4 in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized Angiostatin Kringles 1-4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Angiostatin Kringles1-4 should be stored at 4°C between 2-7 days ａnd for future use below -18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Purity Greater than 98.0% as determined by SDS-PAGE. Biological Activity Human Angiostatin Kringles 1-4 significantly inhibits basic-FGF induced endothelial cell proliferation ａnd migration at concentration ranging from 300nM-1.0 uM. Usage ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Angiostatin K1-4/重组人血管抑素 Kringles 1-4
产品编号：PRO-604
产品规格：2μg/10μg/1mg
Introduction There are several proteolytic fragments or specific domains of proteins that act as inhibitors of angiogenesis. These include fragments of plasminogen such as Angiostatin protein kringles 1-4 ａnd kringles 1-5, Endostatin, Restin, PEX, the N-terminal fragment of prolactin, ａnd the Nterminally truncated platelet factor. Angiostatin is a proteolytic protein fragment of plasminogen that is comprised of the first 4 kringle regions. Angiostatin k1-4 prevents the growth of endothelial cells, ａnd its systemic administration inhibits the growth of primary carcinomas in mice. Angiostatin Kringles 1-3 segment has a larger inhibitory activity than the Angiostatin kringles 1-4 fragment. The protease-activated angiostatin kringles 1-5 is the most potent plasminogen fragment with over 50 times larger endothelial cell specific inhibitory activity. Angiostatin kringles 1-5 systemic administration inhibits growth of fibrosarcoma ａnd significantly reduces neovascularization.
Angiostatin is an angiogenesis inhibitor in mouse serum ａnd urine. Angiostatin is a 38 kDa protein fragment of the plasminogen composed of the 1st 4 kringle domains of plasminogen. Angiostatin K1-4 is also named plasminogen kringles 1-4 ａnd PK1-4.
Angiostatin protein is manufactured by the protelytic cleavage of plasminogen by a serine protease from several prostate carcinoma cell lines. The manufacturing of angiostatin by pancreatic cancer cells can be inhibited by TGF-beta 1 along with plasminogen activator inhibitor type-1 （PAI1）. Description Human Angiostatin kringles 1-4 is produced from Human Fluid is a glycosylated polypeptide chain which migrates as a doublet 50 kDa on SDS-PAGE.
The Ang K1-4 is purified by proprietary chromatographic techniques. Source Human Fluid. Physical Appearance Sterile Filtered lyophilized powder. Formulation Lyophilized from a （1mg/ml） solution in containing 20mM Hepes buffer pH-8.2 & 20mM NaCl. Solubility It is recommended to reconstitute the lyophilized Angiostatin K1-4 in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized Angiostatin Kringles 1-4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Angiostatin Kringles1-4 should be stored at 4°C between 2-7 days ａnd for future use below -18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Purity Greater than 98.0% as determined by SDS-PAGE. Biological Activity Human Angiostatin Kringles 1-4 significantly inhibits basic-FGF induced endothelial cell proliferation ａnd migration at concentration ranging from 300nM-1.0 uM. Usage ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Angiostatin K1-4/重组人血管抑素 Kringles 1-4
产品编号：PRO-604
产品规格：2μg/10μg/1mg
Introduction There are several proteolytic fragments or specific domains of proteins that act as inhibitors of angiogenesis. These include fragments of plasminogen such as Angiostatin protein kringles 1-4 ａnd kringles 1-5, Endostatin, Restin, PEX, the N-terminal fragment of prolactin, ａnd the Nterminally truncated platelet factor. Angiostatin is a proteolytic protein fragment of plasminogen that is comprised of the first 4 kringle regions. Angiostatin k1-4 prevents the growth of endothelial cells, ａnd its systemic administration inhibits the growth of primary carcinomas in mice. Angiostatin Kringles 1-3 segment has a larger inhibitory activity than the Angiostatin kringles 1-4 fragment. The protease-activated angiostatin kringles 1-5 is the most potent plasminogen fragment with over 50 times larger endothelial cell specific inhibitory activity. Angiostatin kringles 1-5 systemic administration inhibits growth of fibrosarcoma ａnd significantly reduces neovascularization.
Angiostatin is an angiogenesis inhibitor in mouse serum ａnd urine. Angiostatin is a 38 kDa protein fragment of the plasminogen composed of the 1st 4 kringle domains of plasminogen. Angiostatin K1-4 is also named plasminogen kringles 1-4 ａnd PK1-4.
Angiostatin protein is manufactured by the protelytic cleavage of plasminogen by a serine protease from several prostate carcinoma cell lines. The manufacturing of angiostatin by pancreatic cancer cells can be inhibited by TGF-beta 1 along with plasminogen activator inhibitor type-1 （PAI1）. Description Human Angiostatin kringles 1-4 is produced from Human Fluid is a glycosylated polypeptide chain which migrates as a doublet 50 kDa on SDS-PAGE.
The Ang K1-4 is purified by proprietary chromatographic techniques. Source Human Fluid. Physical Appearance Sterile Filtered lyophilized powder. Formulation Lyophilized from a （1mg/ml） solution in containing 20mM Hepes buffer pH-8.2 & 20mM NaCl. Solubility It is recommended to reconstitute the lyophilized Angiostatin K1-4 in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized Angiostatin Kringles 1-4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Angiostatin Kringles1-4 should be stored at 4°C between 2-7 days ａnd for future use below -18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Purity Greater than 98.0% as determined by SDS-PAGE. Biological Activity Human Angiostatin Kringles 1-4 significantly inhibits basic-FGF induced endothelial cell proliferation ａnd migration at concentration ranging from 300nM-1.0 uM. Usage ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Angiostatin K1-4/重组人血管抑素 Kringles 1-4
产品编号：PRO-604
产品规格：2μg/10μg/1mg
Introduction There are several proteolytic fragments or specific domains of proteins that act as inhibitors of angiogenesis. These include fragments of plasminogen such as Angiostatin protein kringles 1-4 ａnd kringles 1-5, Endostatin, Restin, PEX, the N-terminal fragment of prolactin, ａnd the Nterminally truncated platelet factor. Angiostatin is a proteolytic protein fragment of plasminogen that is comprised of the first 4 kringle regions. Angiostatin k1-4 prevents the growth of endothelial cells, ａnd its systemic administration inhibits the growth of primary carcinomas in mice. Angiostatin Kringles 1-3 segment has a larger inhibitory activity than the Angiostatin kringles 1-4 fragment. The protease-activated angiostatin kringles 1-5 is the most potent plasminogen fragment with over 50 times larger endothelial cell specific inhibitory activity. Angiostatin kringles 1-5 systemic administration inhibits growth of fibrosarcoma ａnd significantly reduces neovascularization.
Angiostatin is an angiogenesis inhibitor in mouse serum ａnd urine. Angiostatin is a 38 kDa protein fragment of the plasminogen composed of the 1st 4 kringle domains of plasminogen. Angiostatin K1-4 is also named plasminogen kringles 1-4 ａnd PK1-4.
Angiostatin protein is manufactured by the protelytic cleavage of plasminogen by a serine protease from several prostate carcinoma cell lines. The manufacturing of angiostatin by pancreatic cancer cells can be inhibited by TGF-beta 1 along with plasminogen activator inhibitor type-1 （PAI1）. Description Human Angiostatin kringles 1-4 is produced from Human Fluid is a glycosylated polypeptide chain which migrates as a doublet 50 kDa on SDS-PAGE.
The Ang K1-4 is purified by proprietary chromatographic techniques. Source Human Fluid. Physical Appearance Sterile Filtered lyophilized powder. Formulation Lyophilized from a （1mg/ml） solution in containing 20mM Hepes buffer pH-8.2 & 20mM NaCl. Solubility It is recommended to reconstitute the lyophilized Angiostatin K1-4 in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized Angiostatin Kringles 1-4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Angiostatin Kringles1-4 should be stored at 4°C between 2-7 days ａnd for future use below -18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Purity Greater than 98.0% as determined by SDS-PAGE. Biological Activity Human Angiostatin Kringles 1-4 significantly inhibits basic-FGF induced endothelial cell proliferation ａnd migration at concentration ranging from 300nM-1.0 uM. Usage ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Angiostatin K1-4/重组人血管抑素 Kringles 1-4
产品编号：PRO-604
产品规格：2μg/10μg/1mg
Introduction There are several proteolytic fragments or specific domains of proteins that act as inhibitors of angiogenesis. These include fragments of plasminogen such as Angiostatin protein kringles 1-4 ａnd kringles 1-5, Endostatin, Restin, PEX, the N-terminal fragment of prolactin, ａnd the Nterminally truncated platelet factor. Angiostatin is a proteolytic protein fragment of plasminogen that is comprised of the first 4 kringle regions. Angiostatin k1-4 prevents the growth of endothelial cells, ａnd its systemic administration inhibits the growth of primary carcinomas in mice. Angiostatin Kringles 1-3 segment has a larger inhibitory activity than the Angiostatin kringles 1-4 fragment. The protease-activated angiostatin kringles 1-5 is the most potent plasminogen fragment with over 50 times larger endothelial cell specific inhibitory activity. Angiostatin kringles 1-5 systemic administration inhibits growth of fibrosarcoma ａnd significantly reduces neovascularization.
Angiostatin is an angiogenesis inhibitor in mouse serum ａnd urine. Angiostatin is a 38 kDa protein fragment of the plasminogen composed of the 1st 4 kringle domains of plasminogen. Angiostatin K1-4 is also named plasminogen kringles 1-4 ａnd PK1-4.
Angiostatin protein is manufactured by the protelytic cleavage of plasminogen by a serine protease from several prostate carcinoma cell lines. The manufacturing of angiostatin by pancreatic cancer cells can be inhibited by TGF-beta 1 along with plasminogen activator inhibitor type-1 （PAI1）. Description Human Angiostatin kringles 1-4 is produced from Human Fluid is a glycosylated polypeptide chain which migrates as a doublet 50 kDa on SDS-PAGE.
The Ang K1-4 is purified by proprietary chromatographic techniques. Source Human Fluid. Physical Appearance Sterile Filtered lyophilized powder. Formulation Lyophilized from a （1mg/ml） solution in containing 20mM Hepes buffer pH-8.2 & 20mM NaCl. Solubility It is recommended to reconstitute the lyophilized Angiostatin K1-4 in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized Angiostatin Kringles 1-4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Angiostatin Kringles1-4 should be stored at 4°C between 2-7 days ａnd for future use below -18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Purity Greater than 98.0% as determined by SDS-PAGE. Biological Activity Human Angiostatin Kringles 1-4 significantly inhibits basic-FGF induced endothelial cell proliferation ａnd migration at concentration ranging from 300nM-1.0 uM. Usage ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Angiostatin K1-4/重组人血管抑素 Kringles 1-4
产品编号：PRO-604
产品规格：2μg/10μg/1mg
Introduction There are several proteolytic fragments or specific domains of proteins that act as inhibitors of angiogenesis. These include fragments of plasminogen such as Angiostatin protein kringles 1-4 ａnd kringles 1-5, Endostatin, Restin, PEX, the N-terminal fragment of prolactin, ａnd the Nterminally truncated platelet factor. Angiostatin is a proteolytic protein fragment of plasminogen that is comprised of the first 4 kringle regions. Angiostatin k1-4 prevents the growth of endothelial cells, ａnd its systemic administration inhibits the growth of primary carcinomas in mice. Angiostatin Kringles 1-3 segment has a larger inhibitory activity than the Angiostatin kringles 1-4 fragment. The protease-activated angiostatin kringles 1-5 is the most potent plasminogen fragment with over 50 times larger endothelial cell specific inhibitory activity. Angiostatin kringles 1-5 systemic administration inhibits growth of fibrosarcoma ａnd significantly reduces neovascularization.
Angiostatin is an angiogenesis inhibitor in mouse serum ａnd urine. Angiostatin is a 38 kDa protein fragment of the plasminogen composed of the 1st 4 kringle domains of plasminogen. Angiostatin K1-4 is also named plasminogen kringles 1-4 ａnd PK1-4.
Angiostatin protein is manufactured by the protelytic cleavage of plasminogen by a serine protease from several prostate carcinoma cell lines. The manufacturing of angiostatin by pancreatic cancer cells can be inhibited by TGF-beta 1 along with plasminogen activator inhibitor type-1 （PAI1）. Description Human Angiostatin kringles 1-4 is produced from Human Fluid is a glycosylated polypeptide chain which migrates as a doublet 50 kDa on SDS-PAGE.
The Ang K1-4 is purified by proprietary chromatographic techniques. Source Human Fluid. Physical Appearance Sterile Filtered lyophilized powder. Formulation Lyophilized from a （1mg/ml） solution in containing 20mM Hepes buffer pH-8.2 & 20mM NaCl. Solubility It is recommended to reconstitute the lyophilized Angiostatin K1-4 in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized Angiostatin Kringles 1-4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Angiostatin Kringles1-4 should be stored at 4°C between 2-7 days ａnd for future use below -18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Purity Greater than 98.0% as determined by SDS-PAGE. Biological Activity Human Angiostatin Kringles 1-4 significantly inhibits basic-FGF induced endothelial cell proliferation ａnd migration at concentration ranging from 300nM-1.0 uM. Usage ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Angiostatin K1-4/重组人血管抑素 Kringles 1-4
产品编号：PRO-604
产品规格：2μg/10μg/1mg
Introduction There are several proteolytic fragments or specific domains of proteins that act as inhibitors of angiogenesis. These include fragments of plasminogen such as Angiostatin protein kringles 1-4 ａnd kringles 1-5, Endostatin, Restin, PEX, the N-terminal fragment of prolactin, ａnd the Nterminally truncated platelet factor. Angiostatin is a proteolytic protein fragment of plasminogen that is comprised of the first 4 kringle regions. Angiostatin k1-4 prevents the growth of endothelial cells, ａnd its systemic administration inhibits the growth of primary carcinomas in mice. Angiostatin Kringles 1-3 segment has a larger inhibitory activity than the Angiostatin kringles 1-4 fragment. The protease-activated angiostatin kringles 1-5 is the most potent plasminogen fragment with over 50 times larger endothelial cell specific inhibitory activity. Angiostatin kringles 1-5 systemic administration inhibits growth of fibrosarcoma ａnd significantly reduces neovascularization.
Angiostatin is an angiogenesis inhibitor in mouse serum ａnd urine. Angiostatin is a 38 kDa protein fragment of the plasminogen composed of the 1st 4 kringle domains of plasminogen. Angiostatin K1-4 is also named plasminogen kringles 1-4 ａnd PK1-4.
Angiostatin protein is manufactured by the protelytic cleavage of plasminogen by a serine protease from several prostate carcinoma cell lines. The manufacturing of angiostatin by pancreatic cancer cells can be inhibited by TGF-beta 1 along with plasminogen activator inhibitor type-1 （PAI1）. Description Human Angiostatin kringles 1-4 is produced from Human Fluid is a glycosylated polypeptide chain which migrates as a doublet 50 kDa on SDS-PAGE.
The Ang K1-4 is purified by proprietary chromatographic techniques. Source Human Fluid. Physical Appearance Sterile Filtered lyophilized powder. Formulation Lyophilized from a （1mg/ml） solution in containing 20mM Hepes buffer pH-8.2 & 20mM NaCl. Solubility It is recommended to reconstitute the lyophilized Angiostatin K1-4 in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized Angiostatin Kringles 1-4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Angiostatin Kringles1-4 should be stored at 4°C between 2-7 days ａnd for future use below -18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Purity Greater than 98.0% as determined by SDS-PAGE. Biological Activity Human Angiostatin Kringles 1-4 significantly inhibits basic-FGF induced endothelial cell proliferation ａnd migration at concentration ranging from 300nM-1.0 uM. Usage ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Angiostatin K1-4/重组人血管抑素 Kringles 1-4
产品编号：PRO-604
产品规格：2μg/10μg/1mg
Introduction There are several proteolytic fragments or specific domains of proteins that act as inhibitors of angiogenesis. These include fragments of plasminogen such as Angiostatin protein kringles 1-4 ａnd kringles 1-5, Endostatin, Restin, PEX, the N-terminal fragment of prolactin, ａnd the Nterminally truncated platelet factor. Angiostatin is a proteolytic protein fragment of plasminogen that is comprised of the first 4 kringle regions. Angiostatin k1-4 prevents the growth of endothelial cells, ａnd its systemic administration inhibits the growth of primary carcinomas in mice. Angiostatin Kringles 1-3 segment has a larger inhibitory activity than the Angiostatin kringles 1-4 fragment. The protease-activated angiostatin kringles 1-5 is the most potent plasminogen fragment with over 50 times larger endothelial cell specific inhibitory activity. Angiostatin kringles 1-5 systemic administration inhibits growth of fibrosarcoma ａnd significantly reduces neovascularization.
Angiostatin is an angiogenesis inhibitor in mouse serum ａnd urine. Angiostatin is a 38 kDa protein fragment of the plasminogen composed of the 1st 4 kringle domains of plasminogen. Angiostatin K1-4 is also named plasminogen kringles 1-4 ａnd PK1-4.
Angiostatin protein is manufactured by the protelytic cleavage of plasminogen by a serine protease from several prostate carcinoma cell lines. The manufacturing of angiostatin by pancreatic cancer cells can be inhibited by TGF-beta 1 along with plasminogen activator inhibitor type-1 （PAI1）. Description Human Angiostatin kringles 1-4 is produced from Human Fluid is a glycosylated polypeptide chain which migrates as a doublet 50 kDa on SDS-PAGE.
The Ang K1-4 is purified by proprietary chromatographic techniques. Source Human Fluid. Physical Appearance Sterile Filtered lyophilized powder. Formulation Lyophilized from a （1mg/ml） solution in containing 20mM Hepes buffer pH-8.2 & 20mM NaCl. Solubility It is recommended to reconstitute the lyophilized Angiostatin K1-4 in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized Angiostatin Kringles 1-4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Angiostatin Kringles1-4 should be stored at 4°C between 2-7 days ａnd for future use below -18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Purity Greater than 98.0% as determined by SDS-PAGE. Biological Activity Human Angiostatin Kringles 1-4 significantly inhibits basic-FGF induced endothelial cell proliferation ａnd migration at concentration ranging from 300nM-1.0 uM. Usage ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Angiostatin K1-4/重组人血管抑素 Kringles 1-4
产品编号：PRO-604
产品规格：2μg/10μg/1mg
Introduction There are several proteolytic fragments or specific domains of proteins that act as inhibitors of angiogenesis. These include fragments of plasminogen such as Angiostatin protein kringles 1-4 ａnd kringles 1-5, Endostatin, Restin, PEX, the N-terminal fragment of prolactin, ａnd the Nterminally truncated platelet factor. Angiostatin is a proteolytic protein fragment of plasminogen that is comprised of the first 4 kringle regions. Angiostatin k1-4 prevents the growth of endothelial cells, ａnd its systemic administration inhibits the growth of primary carcinomas in mice. Angiostatin Kringles 1-3 segment has a larger inhibitory activity than the Angiostatin kringles 1-4 fragment. The protease-activated angiostatin kringles 1-5 is the most potent plasminogen fragment with over 50 times larger endothelial cell specific inhibitory activity. Angiostatin kringles 1-5 systemic administration inhibits growth of fibrosarcoma ａnd significantly reduces neovascularization.
Angiostatin is an angiogenesis inhibitor in mouse serum ａnd urine. Angiostatin is a 38 kDa protein fragment of the plasminogen composed of the 1st 4 kringle domains of plasminogen. Angiostatin K1-4 is also named plasminogen kringles 1-4 ａnd PK1-4.
Angiostatin protein is manufactured by the protelytic cleavage of plasminogen by a serine protease from several prostate carcinoma cell lines. The manufacturing of angiostatin by pancreatic cancer cells can be inhibited by TGF-beta 1 along with plasminogen activator inhibitor type-1 （PAI1）. Description Human Angiostatin kringles 1-4 is produced from Human Fluid is a glycosylated polypeptide chain which migrates as a doublet 50 kDa on SDS-PAGE.
The Ang K1-4 is purified by proprietary chromatographic techniques. Source Human Fluid. Physical Appearance Sterile Filtered lyophilized powder. Formulation Lyophilized from a （1mg/ml） solution in containing 20mM Hepes buffer pH-8.2 & 20mM NaCl. Solubility It is recommended to reconstitute the lyophilized Angiostatin K1-4 in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized Angiostatin Kringles 1-4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Angiostatin Kringles1-4 should be stored at 4°C between 2-7 days ａnd for future use below -18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Purity Greater than 98.0% as determined by SDS-PAGE. Biological Activity Human Angiostatin Kringles 1-4 significantly inhibits basic-FGF induced endothelial cell proliferation ａnd migration at concentration ranging from 300nM-1.0 uM. Usage ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Angiostatin K1-4/重组人血管抑素 Kringles 1-4
产品编号：PRO-604
产品规格：2μg/10μg/1mg
产品规格：2μg/10μg/1mg
| Introduction | There are several proteolytic fragments or specific domains of proteins that act as inhibitors of angiogenesis. These include fragments of plasminogen such as Angiostatin protein kringles 1-4 ａnd kringles 1-5, Endostatin, Restin, PEX, the N-terminal fragment of prolactin, ａnd the Nterminally truncated platelet factor. Angiostatin is a proteolytic protein fragment of plasminogen that is comprised of the first 4 kringle regions. Angiostatin k1-4 prevents the growth of endothelial cells, ａnd its systemic administration inhibits the growth of primary carcinomas in mice. Angiostatin Kringles 1-3 segment has a larger inhibitory activity than the Angiostatin kringles 1-4 fragment. The protease-activated angiostatin kringles 1-5 is the most potent plasminogen fragment with over 50 times larger endothelial cell specific inhibitory activity. Angiostatin kringles 1-5 systemic administration inhibits growth of fibrosarcoma ａnd significantly reduces neovascularization. Angiostatin is an angiogenesis inhibitor in mouse serum ａnd urine. Angiostatin is a 38 kDa protein fragment of the plasminogen composed of the 1st 4 kringle domains of plasminogen. Angiostatin K1-4 is also named plasminogen kringles 1-4 ａnd PK1-4. Angiostatin protein is manufactured by the protelytic cleavage of plasminogen by a serine protease from several prostate carcinoma cell lines. The manufacturing of angiostatin by pancreatic cancer cells can be inhibited by TGF-beta 1 along with plasminogen activator inhibitor type-1 （PAI1）. |
| Description | Human Angiostatin kringles 1-4 is produced from Human Fluid is a glycosylated polypeptide chain which migrates as a doublet 50 kDa on SDS-PAGE. The Ang K1-4 is purified by proprietary chromatographic techniques. |
| Source | Human Fluid. |
| Physical Appearance | Sterile Filtered lyophilized powder. |
| Formulation | Lyophilized from a （1mg/ml） solution in containing 20mM Hepes buffer pH-8.2 & 20mM NaCl. |
| Solubility | It is recommended to reconstitute the lyophilized Angiostatin K1-4 in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. |
| Stability | Lyophilized Angiostatin Kringles 1-4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Angiostatin Kringles1-4 should be stored at 4°C between 2-7 days ａnd for future use below -18°C. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles. |
| Purity | Greater than 98.0% as determined by SDS-PAGE. |
| Biological Activity | Human Angiostatin Kringles 1-4 significantly inhibits basic-FGF induced endothelial cell proliferation ａnd migration at concentration ranging from 300nM-1.0 uM. |
| Usage | ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
