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PRO-360 PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
点击次数：188发布时间：2012/7/31 14:50:01
更新日期：2024/10/16 15:58:55
所 在 地：美洲
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厦门慧嘉生物专业销售PRO-360 PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域 ASSAY Santa Abcam Cst jackson Pierce Sigma Amresco Qiagen Cayman abnova millipore invitrogen merk ebioscience prospec peprotech细胞因子特价。等生物试剂产品。实验为大，诚信经营，为客户提供“质量的产品”和“质的服务"QQ: 1193953234 1048735792 或登陆（向客服人员索取原版说明书） http://www.biohj.com 欢迎广大老师来询！
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
Synonyms C-terminal hemopexin-like domain of MMP-2, PEX. Introduction Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo.
Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. Description PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. Source Escherichia Coli. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The protein was lyophilized with 2mM Tris pH-7.4. Solubility It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. Stability Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below
-18°C.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles. Activity The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Sequence MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
PEX Human/重组人MMP-2 C末端血色素结合蛋白样区域
产品编号：PRO-360
产品规格：2μg/10μg/1mg
产品规格：2μg/10μg/1mg
| Synonyms | C-terminal hemopexin-like domain of MMP-2, PEX. |
| Introduction | Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity ａnd can inhibit cell associated collagenolytic activity both in vitro ａnd in vivo. Moreover, PEX can block angiogenesis ａnd tumor growth in vivo, providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis, but when administered in sufficient quantities, may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors ａnd the cell surface, ａnd is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller. PEX, which interferes with the cell membrane activation of MMP-2, reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3. |
| Description | PEX Human Recombinant is expressed as inclusion bodies in E.coli having a molecular mass of 28,453 Dalton ａnd subsequently refolded in vitro to get biological activity. |
| Source | Escherichia Coli. |
| Physical Appearance | Sterile Filtered White lyophilized （freeze-dried） powder. |
| Formulation | The protein was lyophilized with 2mM Tris pH-7.4. |
| Solubility | It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. |
| Stability | Lyophilized PEX although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEX should be stored at 4°C between 2-7 days ａnd for future use below -18°C. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles. |
| Activity | The bioactivity was measured by HMEC cell line, PEX can inhibit the transmembrane activity of HMEC under the stimulation of VEGF. |
| Purity | Greater than 95.0% as determined by（a） Analysis by RP-HPLC. （b） Analysis by SDS-PAGE. |
| Sequence | MGLEHSQDPG ALMAPIYTYT KNFRLSQDDI KGIQELYGAS PDIDLGTGPT PTLGPVTPEI CKQDIVFDGI AQIRGEIFFF KDRFIWRTVT PRDKPMGPLL VATFWPELPE KIDAVYEAPQ EEKAVFFAGN EYWIYSASTL ERGYPKPLTS LGLPPDVQRV DAAFNWSKNK KTYIFAGDKF WRYNEVKKKM DPGFPKLIAD AWNAIPDNLD AVVDLQGGGH SYFFKGAYYL KLENQSLKSV KFGSIKSDWL GC. |
| Usage | Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
