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Prospec PRO-327 LA/SS-B Human/重组人LA/SS-B
点击次数：288发布时间：2012/8/8 17:06:27
更新日期：2024/10/16 15:58:55
所 在 地：美洲
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厦门慧嘉生物专业销售Prospec PRO-327 LA/SS-B Human/重组人LA/SS-B ASSAY ImmunoWay Santa Abcam Cst jackson Pierce Sigma Amresco Qiagen Cayman abnova millipore invitrogen merk ebioscience prospec peprotech细胞因子特价。等生物试剂产品。实验为大，诚信经营，为客户提供“质量的产品”和“质的服务"QQ: 1193953234 1048735792 或登陆（向客服人员索取原版说明书） http://www.biohj.com 欢迎广大老师来询！
LA/SS-B Human/重组人LA/SS-B
产品编号：PRO-327
产品规格：10μg/50μg/1mg
Synonyms Lupus La protein, Sjoegren syndrome type B antigen, SS-B, La ribonucleoprotein, La autoantigen, SSB, La, LARP3, LA/SS-B, La（SS-B）. Introduction The La protein is a 47 kDa polypeptide that frequently acts as an autoantigen in systemic lupus erythematosus ａnd Sjogren＇s syndrome patients. La is involved in various aspects of RNA metabolism, including binding ａnd protecting 3-prime UUU（OH） elements of newly RNA polymerase III - transcribed RNA, processing 5-prime ａnd 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, ａnd binding viral RNAs linked to hepatitis C virus. It occurs in both the nucleus ａnd the cytoplasm, where it assumes different roles. In the nucleus, La protein facilitates the production of tRNAs, acting as an RNA polymerase III （RNAP III） transcription factor by attaching to the U-rich 3＇UTR of nascent transcripts, aiding in their folding ａnd maturation. In the cytoplasm, La protein facilitates the translation of specific mRNAs, acting as a translation factor. As an RNA binding protein （RBP）, La protein associates with subsets of mRNAs which contain a 5＇-terminal oligopyrimidine （5＇TOP） motif known to direct protein synthesis. The binding of La protein to particular classes of RNA molecules regulates their downstream processing, guards them from endonuclease digestion, ａnd organizes their export from the nucleus. La/SS-B appears to be readily disposed to proteolysis, which results in many smaller （42kD, 320, ａnd 270） nevertheless still immunoreactive polypeptides. La/SS-B antigen is strongly conserved across species. Anti-La/SS-B autoantibodies were originally found as precipitating autoantibodies in sera of Sjogren＇s Syndrome patients ａnd referred to as SjT. Anti-La/SS-B precipitins are most frequently found in Sjogren＇s Syndrome, Systemic Lupus Erythematosus （SLE） ａnd Subacute Cutaneous Lupus. Also, there seems to be a correlation between anti-La/SS-B ａnd the absence of nephritis in SLE patients. Description LA/SS-B Human Recombinant produced in SF9 is a single, glycosylated, polypeptide chain having a calculated molecular mass of 47.6 kDa, is fused to a hexahistidine purification tag.
The LA/SS-B is purified by proprietary chromatographic techniques. Source Sf9 insect cells. Physical Appearance Sterile Filtered clear solution. Formulation The protein solution contains 20mM HEPES, pH 7.5, 400mM NaCl, 20% Glycerol. Immunological functions 1. Binds IgG-type human auto-antibodies.
2. Standard ELISA test （checker-board analysis of positive/negative sera panels, immuno-dot test）. Coating concentration 0.6-1.1 μg/ml （depending on the type of ELISA plate ａnd coating buffer）.
Suitable for biotinylation ａnd iodination. Stability Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
Avoid multiple freeze-thaw cycles. Purity Greater than 95.0% as determined by SDS-PAGE. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
LA/SS-B Human/重组人LA/SS-B
产品编号：PRO-327
产品规格：10μg/50μg/1mg
Synonyms Lupus La protein, Sjoegren syndrome type B antigen, SS-B, La ribonucleoprotein, La autoantigen, SSB, La, LARP3, LA/SS-B, La（SS-B）. Introduction The La protein is a 47 kDa polypeptide that frequently acts as an autoantigen in systemic lupus erythematosus ａnd Sjogren＇s syndrome patients. La is involved in various aspects of RNA metabolism, including binding ａnd protecting 3-prime UUU（OH） elements of newly RNA polymerase III - transcribed RNA, processing 5-prime ａnd 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, ａnd binding viral RNAs linked to hepatitis C virus. It occurs in both the nucleus ａnd the cytoplasm, where it assumes different roles. In the nucleus, La protein facilitates the production of tRNAs, acting as an RNA polymerase III （RNAP III） transcription factor by attaching to the U-rich 3＇UTR of nascent transcripts, aiding in their folding ａnd maturation. In the cytoplasm, La protein facilitates the translation of specific mRNAs, acting as a translation factor. As an RNA binding protein （RBP）, La protein associates with subsets of mRNAs which contain a 5＇-terminal oligopyrimidine （5＇TOP） motif known to direct protein synthesis. The binding of La protein to particular classes of RNA molecules regulates their downstream processing, guards them from endonuclease digestion, ａnd organizes their export from the nucleus. La/SS-B appears to be readily disposed to proteolysis, which results in many smaller （42kD, 320, ａnd 270） nevertheless still immunoreactive polypeptides. La/SS-B antigen is strongly conserved across species. Anti-La/SS-B autoantibodies were originally found as precipitating autoantibodies in sera of Sjogren＇s Syndrome patients ａnd referred to as SjT. Anti-La/SS-B precipitins are most frequently found in Sjogren＇s Syndrome, Systemic Lupus Erythematosus （SLE） ａnd Subacute Cutaneous Lupus. Also, there seems to be a correlation between anti-La/SS-B ａnd the absence of nephritis in SLE patients. Description LA/SS-B Human Recombinant produced in SF9 is a single, glycosylated, polypeptide chain having a calculated molecular mass of 47.6 kDa, is fused to a hexahistidine purification tag.
The LA/SS-B is purified by proprietary chromatographic techniques. Source Sf9 insect cells. Physical Appearance Sterile Filtered clear solution. Formulation The protein solution contains 20mM HEPES, pH 7.5, 400mM NaCl, 20% Glycerol. Immunological functions 1. Binds IgG-type human auto-antibodies.
2. Standard ELISA test （checker-board analysis of positive/negative sera panels, immuno-dot test）. Coating concentration 0.6-1.1 μg/ml （depending on the type of ELISA plate ａnd coating buffer）.
Suitable for biotinylation ａnd iodination. Stability Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
Avoid multiple freeze-thaw cycles. Purity Greater than 95.0% as determined by SDS-PAGE. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
LA/SS-B Human/重组人LA/SS-B
产品编号：PRO-327
产品规格：10μg/50μg/1mg
Synonyms Lupus La protein, Sjoegren syndrome type B antigen, SS-B, La ribonucleoprotein, La autoantigen, SSB, La, LARP3, LA/SS-B, La（SS-B）. Introduction The La protein is a 47 kDa polypeptide that frequently acts as an autoantigen in systemic lupus erythematosus ａnd Sjogren＇s syndrome patients. La is involved in various aspects of RNA metabolism, including binding ａnd protecting 3-prime UUU（OH） elements of newly RNA polymerase III - transcribed RNA, processing 5-prime ａnd 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, ａnd binding viral RNAs linked to hepatitis C virus. It occurs in both the nucleus ａnd the cytoplasm, where it assumes different roles. In the nucleus, La protein facilitates the production of tRNAs, acting as an RNA polymerase III （RNAP III） transcription factor by attaching to the U-rich 3＇UTR of nascent transcripts, aiding in their folding ａnd maturation. In the cytoplasm, La protein facilitates the translation of specific mRNAs, acting as a translation factor. As an RNA binding protein （RBP）, La protein associates with subsets of mRNAs which contain a 5＇-terminal oligopyrimidine （5＇TOP） motif known to direct protein synthesis. The binding of La protein to particular classes of RNA molecules regulates their downstream processing, guards them from endonuclease digestion, ａnd organizes their export from the nucleus. La/SS-B appears to be readily disposed to proteolysis, which results in many smaller （42kD, 320, ａnd 270） nevertheless still immunoreactive polypeptides. La/SS-B antigen is strongly conserved across species. Anti-La/SS-B autoantibodies were originally found as precipitating autoantibodies in sera of Sjogren＇s Syndrome patients ａnd referred to as SjT. Anti-La/SS-B precipitins are most frequently found in Sjogren＇s Syndrome, Systemic Lupus Erythematosus （SLE） ａnd Subacute Cutaneous Lupus. Also, there seems to be a correlation between anti-La/SS-B ａnd the absence of nephritis in SLE patients. Description LA/SS-B Human Recombinant produced in SF9 is a single, glycosylated, polypeptide chain having a calculated molecular mass of 47.6 kDa, is fused to a hexahistidine purification tag.
The LA/SS-B is purified by proprietary chromatographic techniques. Source Sf9 insect cells. Physical Appearance Sterile Filtered clear solution. Formulation The protein solution contains 20mM HEPES, pH 7.5, 400mM NaCl, 20% Glycerol. Immunological functions 1. Binds IgG-type human auto-antibodies.
2. Standard ELISA test （checker-board analysis of positive/negative sera panels, immuno-dot test）. Coating concentration 0.6-1.1 μg/ml （depending on the type of ELISA plate ａnd coating buffer）.
Suitable for biotinylation ａnd iodination. Stability Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
Avoid multiple freeze-thaw cycles. Purity Greater than 95.0% as determined by SDS-PAGE. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
LA/SS-B Human/重组人LA/SS-B
产品编号：PRO-327
产品规格：10μg/50μg/1mg
Synonyms Lupus La protein, Sjoegren syndrome type B antigen, SS-B, La ribonucleoprotein, La autoantigen, SSB, La, LARP3, LA/SS-B, La（SS-B）. Introduction The La protein is a 47 kDa polypeptide that frequently acts as an autoantigen in systemic lupus erythematosus ａnd Sjogren＇s syndrome patients. La is involved in various aspects of RNA metabolism, including binding ａnd protecting 3-prime UUU（OH） elements of newly RNA polymerase III - transcribed RNA, processing 5-prime ａnd 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, ａnd binding viral RNAs linked to hepatitis C virus. It occurs in both the nucleus ａnd the cytoplasm, where it assumes different roles. In the nucleus, La protein facilitates the production of tRNAs, acting as an RNA polymerase III （RNAP III） transcription factor by attaching to the U-rich 3＇UTR of nascent transcripts, aiding in their folding ａnd maturation. In the cytoplasm, La protein facilitates the translation of specific mRNAs, acting as a translation factor. As an RNA binding protein （RBP）, La protein associates with subsets of mRNAs which contain a 5＇-terminal oligopyrimidine （5＇TOP） motif known to direct protein synthesis. The binding of La protein to particular classes of RNA molecules regulates their downstream processing, guards them from endonuclease digestion, ａnd organizes their export from the nucleus. La/SS-B appears to be readily disposed to proteolysis, which results in many smaller （42kD, 320, ａnd 270） nevertheless still immunoreactive polypeptides. La/SS-B antigen is strongly conserved across species. Anti-La/SS-B autoantibodies were originally found as precipitating autoantibodies in sera of Sjogren＇s Syndrome patients ａnd referred to as SjT. Anti-La/SS-B precipitins are most frequently found in Sjogren＇s Syndrome, Systemic Lupus Erythematosus （SLE） ａnd Subacute Cutaneous Lupus. Also, there seems to be a correlation between anti-La/SS-B ａnd the absence of nephritis in SLE patients. Description LA/SS-B Human Recombinant produced in SF9 is a single, glycosylated, polypeptide chain having a calculated molecular mass of 47.6 kDa, is fused to a hexahistidine purification tag.
The LA/SS-B is purified by proprietary chromatographic techniques. Source Sf9 insect cells. Physical Appearance Sterile Filtered clear solution. Formulation The protein solution contains 20mM HEPES, pH 7.5, 400mM NaCl, 20% Glycerol. Immunological functions 1. Binds IgG-type human auto-antibodies.
2. Standard ELISA test （checker-board analysis of positive/negative sera panels, immuno-dot test）. Coating concentration 0.6-1.1 μg/ml （depending on the type of ELISA plate ａnd coating buffer）.
Suitable for biotinylation ａnd iodination. Stability Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
Avoid multiple freeze-thaw cycles. Purity Greater than 95.0% as determined by SDS-PAGE. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
LA/SS-B Human/重组人LA/SS-B
产品编号：PRO-327
产品规格：10μg/50μg/1mg
Synonyms Lupus La protein, Sjoegren syndrome type B antigen, SS-B, La ribonucleoprotein, La autoantigen, SSB, La, LARP3, LA/SS-B, La（SS-B）. Introduction The La protein is a 47 kDa polypeptide that frequently acts as an autoantigen in systemic lupus erythematosus ａnd Sjogren＇s syndrome patients. La is involved in various aspects of RNA metabolism, including binding ａnd protecting 3-prime UUU（OH） elements of newly RNA polymerase III - transcribed RNA, processing 5-prime ａnd 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, ａnd binding viral RNAs linked to hepatitis C virus. It occurs in both the nucleus ａnd the cytoplasm, where it assumes different roles. In the nucleus, La protein facilitates the production of tRNAs, acting as an RNA polymerase III （RNAP III） transcription factor by attaching to the U-rich 3＇UTR of nascent transcripts, aiding in their folding ａnd maturation. In the cytoplasm, La protein facilitates the translation of specific mRNAs, acting as a translation factor. As an RNA binding protein （RBP）, La protein associates with subsets of mRNAs which contain a 5＇-terminal oligopyrimidine （5＇TOP） motif known to direct protein synthesis. The binding of La protein to particular classes of RNA molecules regulates their downstream processing, guards them from endonuclease digestion, ａnd organizes their export from the nucleus. La/SS-B appears to be readily disposed to proteolysis, which results in many smaller （42kD, 320, ａnd 270） nevertheless still immunoreactive polypeptides. La/SS-B antigen is strongly conserved across species. Anti-La/SS-B autoantibodies were originally found as precipitating autoantibodies in sera of Sjogren＇s Syndrome patients ａnd referred to as SjT. Anti-La/SS-B precipitins are most frequently found in Sjogren＇s Syndrome, Systemic Lupus Erythematosus （SLE） ａnd Subacute Cutaneous Lupus. Also, there seems to be a correlation between anti-La/SS-B ａnd the absence of nephritis in SLE patients. Description LA/SS-B Human Recombinant produced in SF9 is a single, glycosylated, polypeptide chain having a calculated molecular mass of 47.6 kDa, is fused to a hexahistidine purification tag.
The LA/SS-B is purified by proprietary chromatographic techniques. Source Sf9 insect cells. Physical Appearance Sterile Filtered clear solution. Formulation The protein solution contains 20mM HEPES, pH 7.5, 400mM NaCl, 20% Glycerol. Immunological functions 1. Binds IgG-type human auto-antibodies.
2. Standard ELISA test （checker-board analysis of positive/negative sera panels, immuno-dot test）. Coating concentration 0.6-1.1 μg/ml （depending on the type of ELISA plate ａnd coating buffer）.
Suitable for biotinylation ａnd iodination. Stability Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
Avoid multiple freeze-thaw cycles. Purity Greater than 95.0% as determined by SDS-PAGE. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
LA/SS-B Human/重组人LA/SS-B
产品编号：PRO-327
产品规格：10μg/50μg/1mg
Synonyms Lupus La protein, Sjoegren syndrome type B antigen, SS-B, La ribonucleoprotein, La autoantigen, SSB, La, LARP3, LA/SS-B, La（SS-B）. Introduction The La protein is a 47 kDa polypeptide that frequently acts as an autoantigen in systemic lupus erythematosus ａnd Sjogren＇s syndrome patients. La is involved in various aspects of RNA metabolism, including binding ａnd protecting 3-prime UUU（OH） elements of newly RNA polymerase III - transcribed RNA, processing 5-prime ａnd 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, ａnd binding viral RNAs linked to hepatitis C virus. It occurs in both the nucleus ａnd the cytoplasm, where it assumes different roles. In the nucleus, La protein facilitates the production of tRNAs, acting as an RNA polymerase III （RNAP III） transcription factor by attaching to the U-rich 3＇UTR of nascent transcripts, aiding in their folding ａnd maturation. In the cytoplasm, La protein facilitates the translation of specific mRNAs, acting as a translation factor. As an RNA binding protein （RBP）, La protein associates with subsets of mRNAs which contain a 5＇-terminal oligopyrimidine （5＇TOP） motif known to direct protein synthesis. The binding of La protein to particular classes of RNA molecules regulates their downstream processing, guards them from endonuclease digestion, ａnd organizes their export from the nucleus. La/SS-B appears to be readily disposed to proteolysis, which results in many smaller （42kD, 320, ａnd 270） nevertheless still immunoreactive polypeptides. La/SS-B antigen is strongly conserved across species. Anti-La/SS-B autoantibodies were originally found as precipitating autoantibodies in sera of Sjogren＇s Syndrome patients ａnd referred to as SjT. Anti-La/SS-B precipitins are most frequently found in Sjogren＇s Syndrome, Systemic Lupus Erythematosus （SLE） ａnd Subacute Cutaneous Lupus. Also, there seems to be a correlation between anti-La/SS-B ａnd the absence of nephritis in SLE patients. Description LA/SS-B Human Recombinant produced in SF9 is a single, glycosylated, polypeptide chain having a calculated molecular mass of 47.6 kDa, is fused to a hexahistidine purification tag.
The LA/SS-B is purified by proprietary chromatographic techniques. Source Sf9 insect cells. Physical Appearance Sterile Filtered clear solution. Formulation The protein solution contains 20mM HEPES, pH 7.5, 400mM NaCl, 20% Glycerol. Immunological functions 1. Binds IgG-type human auto-antibodies.
2. Standard ELISA test （checker-board analysis of positive/negative sera panels, immuno-dot test）. Coating concentration 0.6-1.1 μg/ml （depending on the type of ELISA plate ａnd coating buffer）.
Suitable for biotinylation ａnd iodination. Stability Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
Avoid multiple freeze-thaw cycles. Purity Greater than 95.0% as determined by SDS-PAGE. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
LA/SS-B Human/重组人LA/SS-B
产品编号：PRO-327
产品规格：10μg/50μg/1mg
Synonyms Lupus La protein, Sjoegren syndrome type B antigen, SS-B, La ribonucleoprotein, La autoantigen, SSB, La, LARP3, LA/SS-B, La（SS-B）. Introduction The La protein is a 47 kDa polypeptide that frequently acts as an autoantigen in systemic lupus erythematosus ａnd Sjogren＇s syndrome patients. La is involved in various aspects of RNA metabolism, including binding ａnd protecting 3-prime UUU（OH） elements of newly RNA polymerase III - transcribed RNA, processing 5-prime ａnd 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, ａnd binding viral RNAs linked to hepatitis C virus. It occurs in both the nucleus ａnd the cytoplasm, where it assumes different roles. In the nucleus, La protein facilitates the production of tRNAs, acting as an RNA polymerase III （RNAP III） transcription factor by attaching to the U-rich 3＇UTR of nascent transcripts, aiding in their folding ａnd maturation. In the cytoplasm, La protein facilitates the translation of specific mRNAs, acting as a translation factor. As an RNA binding protein （RBP）, La protein associates with subsets of mRNAs which contain a 5＇-terminal oligopyrimidine （5＇TOP） motif known to direct protein synthesis. The binding of La protein to particular classes of RNA molecules regulates their downstream processing, guards them from endonuclease digestion, ａnd organizes their export from the nucleus. La/SS-B appears to be readily disposed to proteolysis, which results in many smaller （42kD, 320, ａnd 270） nevertheless still immunoreactive polypeptides. La/SS-B antigen is strongly conserved across species. Anti-La/SS-B autoantibodies were originally found as precipitating autoantibodies in sera of Sjogren＇s Syndrome patients ａnd referred to as SjT. Anti-La/SS-B precipitins are most frequently found in Sjogren＇s Syndrome, Systemic Lupus Erythematosus （SLE） ａnd Subacute Cutaneous Lupus. Also, there seems to be a correlation between anti-La/SS-B ａnd the absence of nephritis in SLE patients. Description LA/SS-B Human Recombinant produced in SF9 is a single, glycosylated, polypeptide chain having a calculated molecular mass of 47.6 kDa, is fused to a hexahistidine purification tag.
The LA/SS-B is purified by proprietary chromatographic techniques. Source Sf9 insect cells. Physical Appearance Sterile Filtered clear solution. Formulation The protein solution contains 20mM HEPES, pH 7.5, 400mM NaCl, 20% Glycerol. Immunological functions 1. Binds IgG-type human auto-antibodies.
2. Standard ELISA test （checker-board analysis of positive/negative sera panels, immuno-dot test）. Coating concentration 0.6-1.1 μg/ml （depending on the type of ELISA plate ａnd coating buffer）.
Suitable for biotinylation ａnd iodination. Stability Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
Avoid multiple freeze-thaw cycles. Purity Greater than 95.0% as determined by SDS-PAGE. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
LA/SS-B Human/重组人LA/SS-B
产品编号：PRO-327
产品规格：10μg/50μg/1mg
Synonyms Lupus La protein, Sjoegren syndrome type B antigen, SS-B, La ribonucleoprotein, La autoantigen, SSB, La, LARP3, LA/SS-B, La（SS-B）. Introduction The La protein is a 47 kDa polypeptide that frequently acts as an autoantigen in systemic lupus erythematosus ａnd Sjogren＇s syndrome patients. La is involved in various aspects of RNA metabolism, including binding ａnd protecting 3-prime UUU（OH） elements of newly RNA polymerase III - transcribed RNA, processing 5-prime ａnd 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, ａnd binding viral RNAs linked to hepatitis C virus. It occurs in both the nucleus ａnd the cytoplasm, where it assumes different roles. In the nucleus, La protein facilitates the production of tRNAs, acting as an RNA polymerase III （RNAP III） transcription factor by attaching to the U-rich 3＇UTR of nascent transcripts, aiding in their folding ａnd maturation. In the cytoplasm, La protein facilitates the translation of specific mRNAs, acting as a translation factor. As an RNA binding protein （RBP）, La protein associates with subsets of mRNAs which contain a 5＇-terminal oligopyrimidine （5＇TOP） motif known to direct protein synthesis. The binding of La protein to particular classes of RNA molecules regulates their downstream processing, guards them from endonuclease digestion, ａnd organizes their export from the nucleus. La/SS-B appears to be readily disposed to proteolysis, which results in many smaller （42kD, 320, ａnd 270） nevertheless still immunoreactive polypeptides. La/SS-B antigen is strongly conserved across species. Anti-La/SS-B autoantibodies were originally found as precipitating autoantibodies in sera of Sjogren＇s Syndrome patients ａnd referred to as SjT. Anti-La/SS-B precipitins are most frequently found in Sjogren＇s Syndrome, Systemic Lupus Erythematosus （SLE） ａnd Subacute Cutaneous Lupus. Also, there seems to be a correlation between anti-La/SS-B ａnd the absence of nephritis in SLE patients. Description LA/SS-B Human Recombinant produced in SF9 is a single, glycosylated, polypeptide chain having a calculated molecular mass of 47.6 kDa, is fused to a hexahistidine purification tag.
The LA/SS-B is purified by proprietary chromatographic techniques. Source Sf9 insect cells. Physical Appearance Sterile Filtered clear solution. Formulation The protein solution contains 20mM HEPES, pH 7.5, 400mM NaCl, 20% Glycerol. Immunological functions 1. Binds IgG-type human auto-antibodies.
2. Standard ELISA test （checker-board analysis of positive/negative sera panels, immuno-dot test）. Coating concentration 0.6-1.1 μg/ml （depending on the type of ELISA plate ａnd coating buffer）.
Suitable for biotinylation ａnd iodination. Stability Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
Avoid multiple freeze-thaw cycles. Purity Greater than 95.0% as determined by SDS-PAGE. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
LA/SS-B Human/重组人LA/SS-B
产品编号：PRO-327
产品规格：10μg/50μg/1mg
Synonyms Lupus La protein, Sjoegren syndrome type B antigen, SS-B, La ribonucleoprotein, La autoantigen, SSB, La, LARP3, LA/SS-B, La（SS-B）. Introduction The La protein is a 47 kDa polypeptide that frequently acts as an autoantigen in systemic lupus erythematosus ａnd Sjogren＇s syndrome patients. La is involved in various aspects of RNA metabolism, including binding ａnd protecting 3-prime UUU（OH） elements of newly RNA polymerase III - transcribed RNA, processing 5-prime ａnd 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, ａnd binding viral RNAs linked to hepatitis C virus. It occurs in both the nucleus ａnd the cytoplasm, where it assumes different roles. In the nucleus, La protein facilitates the production of tRNAs, acting as an RNA polymerase III （RNAP III） transcription factor by attaching to the U-rich 3＇UTR of nascent transcripts, aiding in their folding ａnd maturation. In the cytoplasm, La protein facilitates the translation of specific mRNAs, acting as a translation factor. As an RNA binding protein （RBP）, La protein associates with subsets of mRNAs which contain a 5＇-terminal oligopyrimidine （5＇TOP） motif known to direct protein synthesis. The binding of La protein to particular classes of RNA molecules regulates their downstream processing, guards them from endonuclease digestion, ａnd organizes their export from the nucleus. La/SS-B appears to be readily disposed to proteolysis, which results in many smaller （42kD, 320, ａnd 270） nevertheless still immunoreactive polypeptides. La/SS-B antigen is strongly conserved across species. Anti-La/SS-B autoantibodies were originally found as precipitating autoantibodies in sera of Sjogren＇s Syndrome patients ａnd referred to as SjT. Anti-La/SS-B precipitins are most frequently found in Sjogren＇s Syndrome, Systemic Lupus Erythematosus （SLE） ａnd Subacute Cutaneous Lupus. Also, there seems to be a correlation between anti-La/SS-B ａnd the absence of nephritis in SLE patients. Description LA/SS-B Human Recombinant produced in SF9 is a single, glycosylated, polypeptide chain having a calculated molecular mass of 47.6 kDa, is fused to a hexahistidine purification tag.
The LA/SS-B is purified by proprietary chromatographic techniques. Source Sf9 insect cells. Physical Appearance Sterile Filtered clear solution. Formulation The protein solution contains 20mM HEPES, pH 7.5, 400mM NaCl, 20% Glycerol. Immunological functions 1. Binds IgG-type human auto-antibodies.
2. Standard ELISA test （checker-board analysis of positive/negative sera panels, immuno-dot test）. Coating concentration 0.6-1.1 μg/ml （depending on the type of ELISA plate ａnd coating buffer）.
Suitable for biotinylation ａnd iodination. Stability Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
Avoid multiple freeze-thaw cycles. Purity Greater than 95.0% as determined by SDS-PAGE. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
产品规格：10μg/50μg/1mg
| Synonyms | Lupus La protein, Sjoegren syndrome type B antigen, SS-B, La ribonucleoprotein, La autoantigen, SSB, La, LARP3, LA/SS-B, La（SS-B）. |
| Introduction | The La protein is a 47 kDa polypeptide that frequently acts as an autoantigen in systemic lupus erythematosus ａnd Sjogren＇s syndrome patients. La is involved in various aspects of RNA metabolism, including binding ａnd protecting 3-prime UUU（OH） elements of newly RNA polymerase III - transcribed RNA, processing 5-prime ａnd 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, ａnd binding viral RNAs linked to hepatitis C virus. It occurs in both the nucleus ａnd the cytoplasm, where it assumes different roles. In the nucleus, La protein facilitates the production of tRNAs, acting as an RNA polymerase III （RNAP III） transcription factor by attaching to the U-rich 3＇UTR of nascent transcripts, aiding in their folding ａnd maturation. In the cytoplasm, La protein facilitates the translation of specific mRNAs, acting as a translation factor. As an RNA binding protein （RBP）, La protein associates with subsets of mRNAs which contain a 5＇-terminal oligopyrimidine （5＇TOP） motif known to direct protein synthesis. The binding of La protein to particular classes of RNA molecules regulates their downstream processing, guards them from endonuclease digestion, ａnd organizes their export from the nucleus. La/SS-B appears to be readily disposed to proteolysis, which results in many smaller （42kD, 320, ａnd 270） nevertheless still immunoreactive polypeptides. La/SS-B antigen is strongly conserved across species. Anti-La/SS-B autoantibodies were originally found as precipitating autoantibodies in sera of Sjogren＇s Syndrome patients ａnd referred to as SjT. Anti-La/SS-B precipitins are most frequently found in Sjogren＇s Syndrome, Systemic Lupus Erythematosus （SLE） ａnd Subacute Cutaneous Lupus. Also, there seems to be a correlation between anti-La/SS-B ａnd the absence of nephritis in SLE patients. |
| Description | LA/SS-B Human Recombinant produced in SF9 is a single, glycosylated, polypeptide chain having a calculated molecular mass of 47.6 kDa, is fused to a hexahistidine purification tag. The LA/SS-B is purified by proprietary chromatographic techniques. |
| Source | Sf9 insect cells. |
| Physical Appearance | Sterile Filtered clear solution. |
| Formulation | The protein solution contains 20mM HEPES, pH 7.5, 400mM NaCl, 20% Glycerol. |
| Immunological functions | 1. Binds IgG-type human auto-antibodies. 2. Standard ELISA test （checker-board analysis of positive/negative sera panels, immuno-dot test）. |
| Coating concentration | 0.6-1.1 μg/ml （depending on the type of ELISA plate ａnd coating buffer）. Suitable for biotinylation ａnd iodination. |
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Purity | Greater than 95.0% as determined by SDS-PAGE. |
| Usage | Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
