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Prospec PRO-477 HIF1A Human/重组人缺氧诱导因子-1α
点击次数：264发布时间：2012/8/9 14:28:48
更新日期：2024/10/16 15:58:55
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厦门慧嘉生物专业销售Prospec PRO-477 HIF1A Human/重组人缺氧诱导因子-1α ASSAY ImmunoWay Santa Abcam Cst jackson Pierce Sigma Amresco Qiagen Cayman abnova millipore invitrogen merk ebioscience prospec peprotech细胞因子特价。等生物试剂产品。实验为大，诚信经营，为客户提供“质量的产品”和“质的服务"QQ: 1193953234 1048735792 或登陆（向客服人员索取原版说明书） http://www.biohj.com 欢迎广大老师来询！
HIF1A Human/重组人缺氧诱导因子-1α
产品编号：PRO-477
产品规格：10μg/50μg/1mg
Synonyms Hypoxia-inducible factor 1 alpha, HIF-1 alpha, HIF1 alpha, ARNT-interacting protein, Member of PAS protein 1, Basic-helix-loop-helix-PAS protein MOP1, HIF1A, MOP1, HIF1, PASD8, HIF-1A. Introduction Hypoxia-inducible factor-1 （HIF-1）, identified as one of the transcription factors, has been found to play an essential role in cellular ａnd systemic oxygen homeostasis. HIF-1 is a heterodimer composed of HIF-1? subunit ａnd one of three subunits （Hif-1?, Hif-2 （or Hif-3））. The activation of Hif-1 （is closely associated with a variety of tumors ａnd oncogenic pathways. Hif-1 （consists of DNA binding domain （DBD domain）, Dimerization domain ａnd C-terminal regulatory domains, including two transactivation domains （TAD）, an oxygen-dependent degradation （ODD） domain, ａnd inhibitory domains. Under hypoxic conditions HIF1A activates the transcription of more than 40 genes, including, erythropoietin, glucose transporters, glycolytic enzymes, VEGF, ａnd other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1A also plays a crucial role in embryonic vascularization, tumor angiogenesis ａnd pathophysiology of ischemic disease. It binds to core DNA sequence 5＇-[AG]CGTG-3＇ within the hypoxia response element （HRE） of target gene promoters. Activation involves recruitment of transcriptional coactivators such as CREBPB ａnd EP300. Its activity is improved by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX appears to activate CTAD ａnd potentiates activation by NCOA1 ａnd CREBBP. The induction is under reduced oxygen tension. HIF1A is also induced by a variety of receptor-mediated factors such as growth factors, cytokines, ａnd circulatory factors for example PDGF, EGF, FGF-2, IGF-2, TGF-1 beta, HGF, TNF alpha, IL-1 beta, angiotensin-2 ａnd thrombin. Nevertheless, this induction is less intense than that stimulated by hypoxia. Description HIF1A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 298 amino acids （530-826） ａnd having a molecular mass of 32.8 Dalton. The protein migrates as a 40kDa band on SDS-PAGE.
The HIF1-A is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile filtered liquid formulation. Formulation The HIF1A recombinant Human solution is formulated 20mM Tris-HCl pH-7.5 ａnd 1mM DTT. Stability MOP1 Recombinant Human although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days.
Please avoid freeze-thaw cycles. Amino Acid Sequence MEFKLELVEK LFAEDTEAKN PFSTQDTDLD LEMLAPYIPM DDDFQLRSFD QLSPLESSSA SPESASPQST VTVFQQTQIQ EPTANATTTT ATTDELKTVT KDRMEDIKIL IASPSPTHIH KETTSATSSP YRDTQSRTAS PNRAGKGVIE QTEKSHPRSP NVLSVALSQR TTVPEEELNP KILALQNAQR KRKMEHDGSL FQAVGIGTLL QQPDDHAATT SLSWKRVKGC KSSEQNGMEQ KTIILIPSDL ACRLLGQSMD ESGLPQLTSY DCEVNAPIQG SRNLLQGEEL LRALDQVN. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
HIF1A Human/重组人缺氧诱导因子-1α
产品编号：PRO-477
产品规格：10μg/50μg/1mg
Synonyms Hypoxia-inducible factor 1 alpha, HIF-1 alpha, HIF1 alpha, ARNT-interacting protein, Member of PAS protein 1, Basic-helix-loop-helix-PAS protein MOP1, HIF1A, MOP1, HIF1, PASD8, HIF-1A. Introduction Hypoxia-inducible factor-1 （HIF-1）, identified as one of the transcription factors, has been found to play an essential role in cellular ａnd systemic oxygen homeostasis. HIF-1 is a heterodimer composed of HIF-1? subunit ａnd one of three subunits （Hif-1?, Hif-2 （or Hif-3））. The activation of Hif-1 （is closely associated with a variety of tumors ａnd oncogenic pathways. Hif-1 （consists of DNA binding domain （DBD domain）, Dimerization domain ａnd C-terminal regulatory domains, including two transactivation domains （TAD）, an oxygen-dependent degradation （ODD） domain, ａnd inhibitory domains. Under hypoxic conditions HIF1A activates the transcription of more than 40 genes, including, erythropoietin, glucose transporters, glycolytic enzymes, VEGF, ａnd other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1A also plays a crucial role in embryonic vascularization, tumor angiogenesis ａnd pathophysiology of ischemic disease. It binds to core DNA sequence 5＇-[AG]CGTG-3＇ within the hypoxia response element （HRE） of target gene promoters. Activation involves recruitment of transcriptional coactivators such as CREBPB ａnd EP300. Its activity is improved by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX appears to activate CTAD ａnd potentiates activation by NCOA1 ａnd CREBBP. The induction is under reduced oxygen tension. HIF1A is also induced by a variety of receptor-mediated factors such as growth factors, cytokines, ａnd circulatory factors for example PDGF, EGF, FGF-2, IGF-2, TGF-1 beta, HGF, TNF alpha, IL-1 beta, angiotensin-2 ａnd thrombin. Nevertheless, this induction is less intense than that stimulated by hypoxia. Description HIF1A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 298 amino acids （530-826） ａnd having a molecular mass of 32.8 Dalton. The protein migrates as a 40kDa band on SDS-PAGE.
The HIF1-A is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile filtered liquid formulation. Formulation The HIF1A recombinant Human solution is formulated 20mM Tris-HCl pH-7.5 ａnd 1mM DTT. Stability MOP1 Recombinant Human although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days.
Please avoid freeze-thaw cycles. Amino Acid Sequence MEFKLELVEK LFAEDTEAKN PFSTQDTDLD LEMLAPYIPM DDDFQLRSFD QLSPLESSSA SPESASPQST VTVFQQTQIQ EPTANATTTT ATTDELKTVT KDRMEDIKIL IASPSPTHIH KETTSATSSP YRDTQSRTAS PNRAGKGVIE QTEKSHPRSP NVLSVALSQR TTVPEEELNP KILALQNAQR KRKMEHDGSL FQAVGIGTLL QQPDDHAATT SLSWKRVKGC KSSEQNGMEQ KTIILIPSDL ACRLLGQSMD ESGLPQLTSY DCEVNAPIQG SRNLLQGEEL LRALDQVN. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
HIF1A Human/重组人缺氧诱导因子-1α
产品编号：PRO-477
产品规格：10μg/50μg/1mg
Synonyms Hypoxia-inducible factor 1 alpha, HIF-1 alpha, HIF1 alpha, ARNT-interacting protein, Member of PAS protein 1, Basic-helix-loop-helix-PAS protein MOP1, HIF1A, MOP1, HIF1, PASD8, HIF-1A. Introduction Hypoxia-inducible factor-1 （HIF-1）, identified as one of the transcription factors, has been found to play an essential role in cellular ａnd systemic oxygen homeostasis. HIF-1 is a heterodimer composed of HIF-1? subunit ａnd one of three subunits （Hif-1?, Hif-2 （or Hif-3））. The activation of Hif-1 （is closely associated with a variety of tumors ａnd oncogenic pathways. Hif-1 （consists of DNA binding domain （DBD domain）, Dimerization domain ａnd C-terminal regulatory domains, including two transactivation domains （TAD）, an oxygen-dependent degradation （ODD） domain, ａnd inhibitory domains. Under hypoxic conditions HIF1A activates the transcription of more than 40 genes, including, erythropoietin, glucose transporters, glycolytic enzymes, VEGF, ａnd other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1A also plays a crucial role in embryonic vascularization, tumor angiogenesis ａnd pathophysiology of ischemic disease. It binds to core DNA sequence 5＇-[AG]CGTG-3＇ within the hypoxia response element （HRE） of target gene promoters. Activation involves recruitment of transcriptional coactivators such as CREBPB ａnd EP300. Its activity is improved by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX appears to activate CTAD ａnd potentiates activation by NCOA1 ａnd CREBBP. The induction is under reduced oxygen tension. HIF1A is also induced by a variety of receptor-mediated factors such as growth factors, cytokines, ａnd circulatory factors for example PDGF, EGF, FGF-2, IGF-2, TGF-1 beta, HGF, TNF alpha, IL-1 beta, angiotensin-2 ａnd thrombin. Nevertheless, this induction is less intense than that stimulated by hypoxia. Description HIF1A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 298 amino acids （530-826） ａnd having a molecular mass of 32.8 Dalton. The protein migrates as a 40kDa band on SDS-PAGE.
The HIF1-A is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile filtered liquid formulation. Formulation The HIF1A recombinant Human solution is formulated 20mM Tris-HCl pH-7.5 ａnd 1mM DTT. Stability MOP1 Recombinant Human although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days.
Please avoid freeze-thaw cycles. Amino Acid Sequence MEFKLELVEK LFAEDTEAKN PFSTQDTDLD LEMLAPYIPM DDDFQLRSFD QLSPLESSSA SPESASPQST VTVFQQTQIQ EPTANATTTT ATTDELKTVT KDRMEDIKIL IASPSPTHIH KETTSATSSP YRDTQSRTAS PNRAGKGVIE QTEKSHPRSP NVLSVALSQR TTVPEEELNP KILALQNAQR KRKMEHDGSL FQAVGIGTLL QQPDDHAATT SLSWKRVKGC KSSEQNGMEQ KTIILIPSDL ACRLLGQSMD ESGLPQLTSY DCEVNAPIQG SRNLLQGEEL LRALDQVN. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
HIF1A Human/重组人缺氧诱导因子-1α
产品编号：PRO-477
产品规格：10μg/50μg/1mg
Synonyms Hypoxia-inducible factor 1 alpha, HIF-1 alpha, HIF1 alpha, ARNT-interacting protein, Member of PAS protein 1, Basic-helix-loop-helix-PAS protein MOP1, HIF1A, MOP1, HIF1, PASD8, HIF-1A. Introduction Hypoxia-inducible factor-1 （HIF-1）, identified as one of the transcription factors, has been found to play an essential role in cellular ａnd systemic oxygen homeostasis. HIF-1 is a heterodimer composed of HIF-1? subunit ａnd one of three subunits （Hif-1?, Hif-2 （or Hif-3））. The activation of Hif-1 （is closely associated with a variety of tumors ａnd oncogenic pathways. Hif-1 （consists of DNA binding domain （DBD domain）, Dimerization domain ａnd C-terminal regulatory domains, including two transactivation domains （TAD）, an oxygen-dependent degradation （ODD） domain, ａnd inhibitory domains. Under hypoxic conditions HIF1A activates the transcription of more than 40 genes, including, erythropoietin, glucose transporters, glycolytic enzymes, VEGF, ａnd other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1A also plays a crucial role in embryonic vascularization, tumor angiogenesis ａnd pathophysiology of ischemic disease. It binds to core DNA sequence 5＇-[AG]CGTG-3＇ within the hypoxia response element （HRE） of target gene promoters. Activation involves recruitment of transcriptional coactivators such as CREBPB ａnd EP300. Its activity is improved by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX appears to activate CTAD ａnd potentiates activation by NCOA1 ａnd CREBBP. The induction is under reduced oxygen tension. HIF1A is also induced by a variety of receptor-mediated factors such as growth factors, cytokines, ａnd circulatory factors for example PDGF, EGF, FGF-2, IGF-2, TGF-1 beta, HGF, TNF alpha, IL-1 beta, angiotensin-2 ａnd thrombin. Nevertheless, this induction is less intense than that stimulated by hypoxia. Description HIF1A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 298 amino acids （530-826） ａnd having a molecular mass of 32.8 Dalton. The protein migrates as a 40kDa band on SDS-PAGE.
The HIF1-A is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile filtered liquid formulation. Formulation The HIF1A recombinant Human solution is formulated 20mM Tris-HCl pH-7.5 ａnd 1mM DTT. Stability MOP1 Recombinant Human although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days.
Please avoid freeze-thaw cycles. Amino Acid Sequence MEFKLELVEK LFAEDTEAKN PFSTQDTDLD LEMLAPYIPM DDDFQLRSFD QLSPLESSSA SPESASPQST VTVFQQTQIQ EPTANATTTT ATTDELKTVT KDRMEDIKIL IASPSPTHIH KETTSATSSP YRDTQSRTAS PNRAGKGVIE QTEKSHPRSP NVLSVALSQR TTVPEEELNP KILALQNAQR KRKMEHDGSL FQAVGIGTLL QQPDDHAATT SLSWKRVKGC KSSEQNGMEQ KTIILIPSDL ACRLLGQSMD ESGLPQLTSY DCEVNAPIQG SRNLLQGEEL LRALDQVN. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
HIF1A Human/重组人缺氧诱导因子-1α
产品编号：PRO-477
产品规格：10μg/50μg/1mg
Synonyms Hypoxia-inducible factor 1 alpha, HIF-1 alpha, HIF1 alpha, ARNT-interacting protein, Member of PAS protein 1, Basic-helix-loop-helix-PAS protein MOP1, HIF1A, MOP1, HIF1, PASD8, HIF-1A. Introduction Hypoxia-inducible factor-1 （HIF-1）, identified as one of the transcription factors, has been found to play an essential role in cellular ａnd systemic oxygen homeostasis. HIF-1 is a heterodimer composed of HIF-1? subunit ａnd one of three subunits （Hif-1?, Hif-2 （or Hif-3））. The activation of Hif-1 （is closely associated with a variety of tumors ａnd oncogenic pathways. Hif-1 （consists of DNA binding domain （DBD domain）, Dimerization domain ａnd C-terminal regulatory domains, including two transactivation domains （TAD）, an oxygen-dependent degradation （ODD） domain, ａnd inhibitory domains. Under hypoxic conditions HIF1A activates the transcription of more than 40 genes, including, erythropoietin, glucose transporters, glycolytic enzymes, VEGF, ａnd other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1A also plays a crucial role in embryonic vascularization, tumor angiogenesis ａnd pathophysiology of ischemic disease. It binds to core DNA sequence 5＇-[AG]CGTG-3＇ within the hypoxia response element （HRE） of target gene promoters. Activation involves recruitment of transcriptional coactivators such as CREBPB ａnd EP300. Its activity is improved by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX appears to activate CTAD ａnd potentiates activation by NCOA1 ａnd CREBBP. The induction is under reduced oxygen tension. HIF1A is also induced by a variety of receptor-mediated factors such as growth factors, cytokines, ａnd circulatory factors for example PDGF, EGF, FGF-2, IGF-2, TGF-1 beta, HGF, TNF alpha, IL-1 beta, angiotensin-2 ａnd thrombin. Nevertheless, this induction is less intense than that stimulated by hypoxia. Description HIF1A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 298 amino acids （530-826） ａnd having a molecular mass of 32.8 Dalton. The protein migrates as a 40kDa band on SDS-PAGE.
The HIF1-A is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile filtered liquid formulation. Formulation The HIF1A recombinant Human solution is formulated 20mM Tris-HCl pH-7.5 ａnd 1mM DTT. Stability MOP1 Recombinant Human although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days.
Please avoid freeze-thaw cycles. Amino Acid Sequence MEFKLELVEK LFAEDTEAKN PFSTQDTDLD LEMLAPYIPM DDDFQLRSFD QLSPLESSSA SPESASPQST VTVFQQTQIQ EPTANATTTT ATTDELKTVT KDRMEDIKIL IASPSPTHIH KETTSATSSP YRDTQSRTAS PNRAGKGVIE QTEKSHPRSP NVLSVALSQR TTVPEEELNP KILALQNAQR KRKMEHDGSL FQAVGIGTLL QQPDDHAATT SLSWKRVKGC KSSEQNGMEQ KTIILIPSDL ACRLLGQSMD ESGLPQLTSY DCEVNAPIQG SRNLLQGEEL LRALDQVN. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
HIF1A Human/重组人缺氧诱导因子-1α
产品编号：PRO-477
产品规格：10μg/50μg/1mg
Synonyms Hypoxia-inducible factor 1 alpha, HIF-1 alpha, HIF1 alpha, ARNT-interacting protein, Member of PAS protein 1, Basic-helix-loop-helix-PAS protein MOP1, HIF1A, MOP1, HIF1, PASD8, HIF-1A. Introduction Hypoxia-inducible factor-1 （HIF-1）, identified as one of the transcription factors, has been found to play an essential role in cellular ａnd systemic oxygen homeostasis. HIF-1 is a heterodimer composed of HIF-1? subunit ａnd one of three subunits （Hif-1?, Hif-2 （or Hif-3））. The activation of Hif-1 （is closely associated with a variety of tumors ａnd oncogenic pathways. Hif-1 （consists of DNA binding domain （DBD domain）, Dimerization domain ａnd C-terminal regulatory domains, including two transactivation domains （TAD）, an oxygen-dependent degradation （ODD） domain, ａnd inhibitory domains. Under hypoxic conditions HIF1A activates the transcription of more than 40 genes, including, erythropoietin, glucose transporters, glycolytic enzymes, VEGF, ａnd other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1A also plays a crucial role in embryonic vascularization, tumor angiogenesis ａnd pathophysiology of ischemic disease. It binds to core DNA sequence 5＇-[AG]CGTG-3＇ within the hypoxia response element （HRE） of target gene promoters. Activation involves recruitment of transcriptional coactivators such as CREBPB ａnd EP300. Its activity is improved by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX appears to activate CTAD ａnd potentiates activation by NCOA1 ａnd CREBBP. The induction is under reduced oxygen tension. HIF1A is also induced by a variety of receptor-mediated factors such as growth factors, cytokines, ａnd circulatory factors for example PDGF, EGF, FGF-2, IGF-2, TGF-1 beta, HGF, TNF alpha, IL-1 beta, angiotensin-2 ａnd thrombin. Nevertheless, this induction is less intense than that stimulated by hypoxia. Description HIF1A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 298 amino acids （530-826） ａnd having a molecular mass of 32.8 Dalton. The protein migrates as a 40kDa band on SDS-PAGE.
The HIF1-A is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile filtered liquid formulation. Formulation The HIF1A recombinant Human solution is formulated 20mM Tris-HCl pH-7.5 ａnd 1mM DTT. Stability MOP1 Recombinant Human although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days.
Please avoid freeze-thaw cycles. Amino Acid Sequence MEFKLELVEK LFAEDTEAKN PFSTQDTDLD LEMLAPYIPM DDDFQLRSFD QLSPLESSSA SPESASPQST VTVFQQTQIQ EPTANATTTT ATTDELKTVT KDRMEDIKIL IASPSPTHIH KETTSATSSP YRDTQSRTAS PNRAGKGVIE QTEKSHPRSP NVLSVALSQR TTVPEEELNP KILALQNAQR KRKMEHDGSL FQAVGIGTLL QQPDDHAATT SLSWKRVKGC KSSEQNGMEQ KTIILIPSDL ACRLLGQSMD ESGLPQLTSY DCEVNAPIQG SRNLLQGEEL LRALDQVN. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
HIF1A Human/重组人缺氧诱导因子-1α
产品编号：PRO-477
产品规格：10μg/50μg/1mg
Synonyms Hypoxia-inducible factor 1 alpha, HIF-1 alpha, HIF1 alpha, ARNT-interacting protein, Member of PAS protein 1, Basic-helix-loop-helix-PAS protein MOP1, HIF1A, MOP1, HIF1, PASD8, HIF-1A. Introduction Hypoxia-inducible factor-1 （HIF-1）, identified as one of the transcription factors, has been found to play an essential role in cellular ａnd systemic oxygen homeostasis. HIF-1 is a heterodimer composed of HIF-1? subunit ａnd one of three subunits （Hif-1?, Hif-2 （or Hif-3））. The activation of Hif-1 （is closely associated with a variety of tumors ａnd oncogenic pathways. Hif-1 （consists of DNA binding domain （DBD domain）, Dimerization domain ａnd C-terminal regulatory domains, including two transactivation domains （TAD）, an oxygen-dependent degradation （ODD） domain, ａnd inhibitory domains. Under hypoxic conditions HIF1A activates the transcription of more than 40 genes, including, erythropoietin, glucose transporters, glycolytic enzymes, VEGF, ａnd other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1A also plays a crucial role in embryonic vascularization, tumor angiogenesis ａnd pathophysiology of ischemic disease. It binds to core DNA sequence 5＇-[AG]CGTG-3＇ within the hypoxia response element （HRE） of target gene promoters. Activation involves recruitment of transcriptional coactivators such as CREBPB ａnd EP300. Its activity is improved by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX appears to activate CTAD ａnd potentiates activation by NCOA1 ａnd CREBBP. The induction is under reduced oxygen tension. HIF1A is also induced by a variety of receptor-mediated factors such as growth factors, cytokines, ａnd circulatory factors for example PDGF, EGF, FGF-2, IGF-2, TGF-1 beta, HGF, TNF alpha, IL-1 beta, angiotensin-2 ａnd thrombin. Nevertheless, this induction is less intense than that stimulated by hypoxia. Description HIF1A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 298 amino acids （530-826） ａnd having a molecular mass of 32.8 Dalton. The protein migrates as a 40kDa band on SDS-PAGE.
The HIF1-A is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile filtered liquid formulation. Formulation The HIF1A recombinant Human solution is formulated 20mM Tris-HCl pH-7.5 ａnd 1mM DTT. Stability MOP1 Recombinant Human although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days.
Please avoid freeze-thaw cycles. Amino Acid Sequence MEFKLELVEK LFAEDTEAKN PFSTQDTDLD LEMLAPYIPM DDDFQLRSFD QLSPLESSSA SPESASPQST VTVFQQTQIQ EPTANATTTT ATTDELKTVT KDRMEDIKIL IASPSPTHIH KETTSATSSP YRDTQSRTAS PNRAGKGVIE QTEKSHPRSP NVLSVALSQR TTVPEEELNP KILALQNAQR KRKMEHDGSL FQAVGIGTLL QQPDDHAATT SLSWKRVKGC KSSEQNGMEQ KTIILIPSDL ACRLLGQSMD ESGLPQLTSY DCEVNAPIQG SRNLLQGEEL LRALDQVN. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
HIF1A Human/重组人缺氧诱导因子-1α
产品编号：PRO-477
产品规格：10μg/50μg/1mg
Synonyms Hypoxia-inducible factor 1 alpha, HIF-1 alpha, HIF1 alpha, ARNT-interacting protein, Member of PAS protein 1, Basic-helix-loop-helix-PAS protein MOP1, HIF1A, MOP1, HIF1, PASD8, HIF-1A. Introduction Hypoxia-inducible factor-1 （HIF-1）, identified as one of the transcription factors, has been found to play an essential role in cellular ａnd systemic oxygen homeostasis. HIF-1 is a heterodimer composed of HIF-1? subunit ａnd one of three subunits （Hif-1?, Hif-2 （or Hif-3））. The activation of Hif-1 （is closely associated with a variety of tumors ａnd oncogenic pathways. Hif-1 （consists of DNA binding domain （DBD domain）, Dimerization domain ａnd C-terminal regulatory domains, including two transactivation domains （TAD）, an oxygen-dependent degradation （ODD） domain, ａnd inhibitory domains. Under hypoxic conditions HIF1A activates the transcription of more than 40 genes, including, erythropoietin, glucose transporters, glycolytic enzymes, VEGF, ａnd other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1A also plays a crucial role in embryonic vascularization, tumor angiogenesis ａnd pathophysiology of ischemic disease. It binds to core DNA sequence 5＇-[AG]CGTG-3＇ within the hypoxia response element （HRE） of target gene promoters. Activation involves recruitment of transcriptional coactivators such as CREBPB ａnd EP300. Its activity is improved by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX appears to activate CTAD ａnd potentiates activation by NCOA1 ａnd CREBBP. The induction is under reduced oxygen tension. HIF1A is also induced by a variety of receptor-mediated factors such as growth factors, cytokines, ａnd circulatory factors for example PDGF, EGF, FGF-2, IGF-2, TGF-1 beta, HGF, TNF alpha, IL-1 beta, angiotensin-2 ａnd thrombin. Nevertheless, this induction is less intense than that stimulated by hypoxia. Description HIF1A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 298 amino acids （530-826） ａnd having a molecular mass of 32.8 Dalton. The protein migrates as a 40kDa band on SDS-PAGE.
The HIF1-A is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile filtered liquid formulation. Formulation The HIF1A recombinant Human solution is formulated 20mM Tris-HCl pH-7.5 ａnd 1mM DTT. Stability MOP1 Recombinant Human although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days.
Please avoid freeze-thaw cycles. Amino Acid Sequence MEFKLELVEK LFAEDTEAKN PFSTQDTDLD LEMLAPYIPM DDDFQLRSFD QLSPLESSSA SPESASPQST VTVFQQTQIQ EPTANATTTT ATTDELKTVT KDRMEDIKIL IASPSPTHIH KETTSATSSP YRDTQSRTAS PNRAGKGVIE QTEKSHPRSP NVLSVALSQR TTVPEEELNP KILALQNAQR KRKMEHDGSL FQAVGIGTLL QQPDDHAATT SLSWKRVKGC KSSEQNGMEQ KTIILIPSDL ACRLLGQSMD ESGLPQLTSY DCEVNAPIQG SRNLLQGEEL LRALDQVN. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
HIF1A Human/重组人缺氧诱导因子-1α
产品编号：PRO-477
产品规格：10μg/50μg/1mg
Synonyms Hypoxia-inducible factor 1 alpha, HIF-1 alpha, HIF1 alpha, ARNT-interacting protein, Member of PAS protein 1, Basic-helix-loop-helix-PAS protein MOP1, HIF1A, MOP1, HIF1, PASD8, HIF-1A. Introduction Hypoxia-inducible factor-1 （HIF-1）, identified as one of the transcription factors, has been found to play an essential role in cellular ａnd systemic oxygen homeostasis. HIF-1 is a heterodimer composed of HIF-1? subunit ａnd one of three subunits （Hif-1?, Hif-2 （or Hif-3））. The activation of Hif-1 （is closely associated with a variety of tumors ａnd oncogenic pathways. Hif-1 （consists of DNA binding domain （DBD domain）, Dimerization domain ａnd C-terminal regulatory domains, including two transactivation domains （TAD）, an oxygen-dependent degradation （ODD） domain, ａnd inhibitory domains. Under hypoxic conditions HIF1A activates the transcription of more than 40 genes, including, erythropoietin, glucose transporters, glycolytic enzymes, VEGF, ａnd other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1A also plays a crucial role in embryonic vascularization, tumor angiogenesis ａnd pathophysiology of ischemic disease. It binds to core DNA sequence 5＇-[AG]CGTG-3＇ within the hypoxia response element （HRE） of target gene promoters. Activation involves recruitment of transcriptional coactivators such as CREBPB ａnd EP300. Its activity is improved by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX appears to activate CTAD ａnd potentiates activation by NCOA1 ａnd CREBBP. The induction is under reduced oxygen tension. HIF1A is also induced by a variety of receptor-mediated factors such as growth factors, cytokines, ａnd circulatory factors for example PDGF, EGF, FGF-2, IGF-2, TGF-1 beta, HGF, TNF alpha, IL-1 beta, angiotensin-2 ａnd thrombin. Nevertheless, this induction is less intense than that stimulated by hypoxia. Description HIF1A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 298 amino acids （530-826） ａnd having a molecular mass of 32.8 Dalton. The protein migrates as a 40kDa band on SDS-PAGE.
The HIF1-A is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile filtered liquid formulation. Formulation The HIF1A recombinant Human solution is formulated 20mM Tris-HCl pH-7.5 ａnd 1mM DTT. Stability MOP1 Recombinant Human although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days.
Please avoid freeze-thaw cycles. Amino Acid Sequence MEFKLELVEK LFAEDTEAKN PFSTQDTDLD LEMLAPYIPM DDDFQLRSFD QLSPLESSSA SPESASPQST VTVFQQTQIQ EPTANATTTT ATTDELKTVT KDRMEDIKIL IASPSPTHIH KETTSATSSP YRDTQSRTAS PNRAGKGVIE QTEKSHPRSP NVLSVALSQR TTVPEEELNP KILALQNAQR KRKMEHDGSL FQAVGIGTLL QQPDDHAATT SLSWKRVKGC KSSEQNGMEQ KTIILIPSDL ACRLLGQSMD ESGLPQLTSY DCEVNAPIQG SRNLLQGEEL LRALDQVN. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
HIF1A Human/重组人缺氧诱导因子-1α
产品编号：PRO-477
产品规格：10μg/50μg/1mg
Synonyms Hypoxia-inducible factor 1 alpha, HIF-1 alpha, HIF1 alpha, ARNT-interacting protein, Member of PAS protein 1, Basic-helix-loop-helix-PAS protein MOP1, HIF1A, MOP1, HIF1, PASD8, HIF-1A. Introduction Hypoxia-inducible factor-1 （HIF-1）, identified as one of the transcription factors, has been found to play an essential role in cellular ａnd systemic oxygen homeostasis. HIF-1 is a heterodimer composed of HIF-1? subunit ａnd one of three subunits （Hif-1?, Hif-2 （or Hif-3））. The activation of Hif-1 （is closely associated with a variety of tumors ａnd oncogenic pathways. Hif-1 （consists of DNA binding domain （DBD domain）, Dimerization domain ａnd C-terminal regulatory domains, including two transactivation domains （TAD）, an oxygen-dependent degradation （ODD） domain, ａnd inhibitory domains. Under hypoxic conditions HIF1A activates the transcription of more than 40 genes, including, erythropoietin, glucose transporters, glycolytic enzymes, VEGF, ａnd other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1A also plays a crucial role in embryonic vascularization, tumor angiogenesis ａnd pathophysiology of ischemic disease. It binds to core DNA sequence 5＇-[AG]CGTG-3＇ within the hypoxia response element （HRE） of target gene promoters. Activation involves recruitment of transcriptional coactivators such as CREBPB ａnd EP300. Its activity is improved by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX appears to activate CTAD ａnd potentiates activation by NCOA1 ａnd CREBBP. The induction is under reduced oxygen tension. HIF1A is also induced by a variety of receptor-mediated factors such as growth factors, cytokines, ａnd circulatory factors for example PDGF, EGF, FGF-2, IGF-2, TGF-1 beta, HGF, TNF alpha, IL-1 beta, angiotensin-2 ａnd thrombin. Nevertheless, this induction is less intense than that stimulated by hypoxia. Description HIF1A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 298 amino acids （530-826） ａnd having a molecular mass of 32.8 Dalton. The protein migrates as a 40kDa band on SDS-PAGE.
The HIF1-A is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile filtered liquid formulation. Formulation The HIF1A recombinant Human solution is formulated 20mM Tris-HCl pH-7.5 ａnd 1mM DTT. Stability MOP1 Recombinant Human although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days.
Please avoid freeze-thaw cycles. Amino Acid Sequence MEFKLELVEK LFAEDTEAKN PFSTQDTDLD LEMLAPYIPM DDDFQLRSFD QLSPLESSSA SPESASPQST VTVFQQTQIQ EPTANATTTT ATTDELKTVT KDRMEDIKIL IASPSPTHIH KETTSATSSP YRDTQSRTAS PNRAGKGVIE QTEKSHPRSP NVLSVALSQR TTVPEEELNP KILALQNAQR KRKMEHDGSL FQAVGIGTLL QQPDDHAATT SLSWKRVKGC KSSEQNGMEQ KTIILIPSDL ACRLLGQSMD ESGLPQLTSY DCEVNAPIQG SRNLLQGEEL LRALDQVN. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
HIF1A Human/重组人缺氧诱导因子-1α
产品编号：PRO-477
产品规格：10μg/50μg/1mg
Synonyms Hypoxia-inducible factor 1 alpha, HIF-1 alpha, HIF1 alpha, ARNT-interacting protein, Member of PAS protein 1, Basic-helix-loop-helix-PAS protein MOP1, HIF1A, MOP1, HIF1, PASD8, HIF-1A. Introduction Hypoxia-inducible factor-1 （HIF-1）, identified as one of the transcription factors, has been found to play an essential role in cellular ａnd systemic oxygen homeostasis. HIF-1 is a heterodimer composed of HIF-1? subunit ａnd one of three subunits （Hif-1?, Hif-2 （or Hif-3））. The activation of Hif-1 （is closely associated with a variety of tumors ａnd oncogenic pathways. Hif-1 （consists of DNA binding domain （DBD domain）, Dimerization domain ａnd C-terminal regulatory domains, including two transactivation domains （TAD）, an oxygen-dependent degradation （ODD） domain, ａnd inhibitory domains. Under hypoxic conditions HIF1A activates the transcription of more than 40 genes, including, erythropoietin, glucose transporters, glycolytic enzymes, VEGF, ａnd other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1A also plays a crucial role in embryonic vascularization, tumor angiogenesis ａnd pathophysiology of ischemic disease. It binds to core DNA sequence 5＇-[AG]CGTG-3＇ within the hypoxia response element （HRE） of target gene promoters. Activation involves recruitment of transcriptional coactivators such as CREBPB ａnd EP300. Its activity is improved by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX appears to activate CTAD ａnd potentiates activation by NCOA1 ａnd CREBBP. The induction is under reduced oxygen tension. HIF1A is also induced by a variety of receptor-mediated factors such as growth factors, cytokines, ａnd circulatory factors for example PDGF, EGF, FGF-2, IGF-2, TGF-1 beta, HGF, TNF alpha, IL-1 beta, angiotensin-2 ａnd thrombin. Nevertheless, this induction is less intense than that stimulated by hypoxia. Description HIF1A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 298 amino acids （530-826） ａnd having a molecular mass of 32.8 Dalton. The protein migrates as a 40kDa band on SDS-PAGE.
The HIF1-A is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile filtered liquid formulation. Formulation The HIF1A recombinant Human solution is formulated 20mM Tris-HCl pH-7.5 ａnd 1mM DTT. Stability MOP1 Recombinant Human although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days.
Please avoid freeze-thaw cycles. Amino Acid Sequence MEFKLELVEK LFAEDTEAKN PFSTQDTDLD LEMLAPYIPM DDDFQLRSFD QLSPLESSSA SPESASPQST VTVFQQTQIQ EPTANATTTT ATTDELKTVT KDRMEDIKIL IASPSPTHIH KETTSATSSP YRDTQSRTAS PNRAGKGVIE QTEKSHPRSP NVLSVALSQR TTVPEEELNP KILALQNAQR KRKMEHDGSL FQAVGIGTLL QQPDDHAATT SLSWKRVKGC KSSEQNGMEQ KTIILIPSDL ACRLLGQSMD ESGLPQLTSY DCEVNAPIQG SRNLLQGEEL LRALDQVN. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
HIF1A Human/重组人缺氧诱导因子-1α
产品编号：PRO-477
产品规格：10μg/50μg/1mg
Synonyms Hypoxia-inducible factor 1 alpha, HIF-1 alpha, HIF1 alpha, ARNT-interacting protein, Member of PAS protein 1, Basic-helix-loop-helix-PAS protein MOP1, HIF1A, MOP1, HIF1, PASD8, HIF-1A. Introduction Hypoxia-inducible factor-1 （HIF-1）, identified as one of the transcription factors, has been found to play an essential role in cellular ａnd systemic oxygen homeostasis. HIF-1 is a heterodimer composed of HIF-1? subunit ａnd one of three subunits （Hif-1?, Hif-2 （or Hif-3））. The activation of Hif-1 （is closely associated with a variety of tumors ａnd oncogenic pathways. Hif-1 （consists of DNA binding domain （DBD domain）, Dimerization domain ａnd C-terminal regulatory domains, including two transactivation domains （TAD）, an oxygen-dependent degradation （ODD） domain, ａnd inhibitory domains. Under hypoxic conditions HIF1A activates the transcription of more than 40 genes, including, erythropoietin, glucose transporters, glycolytic enzymes, VEGF, ａnd other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1A also plays a crucial role in embryonic vascularization, tumor angiogenesis ａnd pathophysiology of ischemic disease. It binds to core DNA sequence 5＇-[AG]CGTG-3＇ within the hypoxia response element （HRE） of target gene promoters. Activation involves recruitment of transcriptional coactivators such as CREBPB ａnd EP300. Its activity is improved by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX appears to activate CTAD ａnd potentiates activation by NCOA1 ａnd CREBBP. The induction is under reduced oxygen tension. HIF1A is also induced by a variety of receptor-mediated factors such as growth factors, cytokines, ａnd circulatory factors for example PDGF, EGF, FGF-2, IGF-2, TGF-1 beta, HGF, TNF alpha, IL-1 beta, angiotensin-2 ａnd thrombin. Nevertheless, this induction is less intense than that stimulated by hypoxia. Description HIF1A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 298 amino acids （530-826） ａnd having a molecular mass of 32.8 Dalton. The protein migrates as a 40kDa band on SDS-PAGE.
The HIF1-A is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile filtered liquid formulation. Formulation The HIF1A recombinant Human solution is formulated 20mM Tris-HCl pH-7.5 ａnd 1mM DTT. Stability MOP1 Recombinant Human although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days.
Please avoid freeze-thaw cycles. Amino Acid Sequence MEFKLELVEK LFAEDTEAKN PFSTQDTDLD LEMLAPYIPM DDDFQLRSFD QLSPLESSSA SPESASPQST VTVFQQTQIQ EPTANATTTT ATTDELKTVT KDRMEDIKIL IASPSPTHIH KETTSATSSP YRDTQSRTAS PNRAGKGVIE QTEKSHPRSP NVLSVALSQR TTVPEEELNP KILALQNAQR KRKMEHDGSL FQAVGIGTLL QQPDDHAATT SLSWKRVKGC KSSEQNGMEQ KTIILIPSDL ACRLLGQSMD ESGLPQLTSY DCEVNAPIQG SRNLLQGEEL LRALDQVN. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
HIF1A Human/重组人缺氧诱导因子-1α
产品编号：PRO-477
产品规格：10μg/50μg/1mg
Synonyms Hypoxia-inducible factor 1 alpha, HIF-1 alpha, HIF1 alpha, ARNT-interacting protein, Member of PAS protein 1, Basic-helix-loop-helix-PAS protein MOP1, HIF1A, MOP1, HIF1, PASD8, HIF-1A. Introduction Hypoxia-inducible factor-1 （HIF-1）, identified as one of the transcription factors, has been found to play an essential role in cellular ａnd systemic oxygen homeostasis. HIF-1 is a heterodimer composed of HIF-1? subunit ａnd one of three subunits （Hif-1?, Hif-2 （or Hif-3））. The activation of Hif-1 （is closely associated with a variety of tumors ａnd oncogenic pathways. Hif-1 （consists of DNA binding domain （DBD domain）, Dimerization domain ａnd C-terminal regulatory domains, including two transactivation domains （TAD）, an oxygen-dependent degradation （ODD） domain, ａnd inhibitory domains. Under hypoxic conditions HIF1A activates the transcription of more than 40 genes, including, erythropoietin, glucose transporters, glycolytic enzymes, VEGF, ａnd other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1A also plays a crucial role in embryonic vascularization, tumor angiogenesis ａnd pathophysiology of ischemic disease. It binds to core DNA sequence 5＇-[AG]CGTG-3＇ within the hypoxia response element （HRE） of target gene promoters. Activation involves recruitment of transcriptional coactivators such as CREBPB ａnd EP300. Its activity is improved by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX appears to activate CTAD ａnd potentiates activation by NCOA1 ａnd CREBBP. The induction is under reduced oxygen tension. HIF1A is also induced by a variety of receptor-mediated factors such as growth factors, cytokines, ａnd circulatory factors for example PDGF, EGF, FGF-2, IGF-2, TGF-1 beta, HGF, TNF alpha, IL-1 beta, angiotensin-2 ａnd thrombin. Nevertheless, this induction is less intense than that stimulated by hypoxia. Description HIF1A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 298 amino acids （530-826） ａnd having a molecular mass of 32.8 Dalton. The protein migrates as a 40kDa band on SDS-PAGE.
The HIF1-A is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile filtered liquid formulation. Formulation The HIF1A recombinant Human solution is formulated 20mM Tris-HCl pH-7.5 ａnd 1mM DTT. Stability MOP1 Recombinant Human although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days.
Please avoid freeze-thaw cycles. Amino Acid Sequence MEFKLELVEK LFAEDTEAKN PFSTQDTDLD LEMLAPYIPM DDDFQLRSFD QLSPLESSSA SPESASPQST VTVFQQTQIQ EPTANATTTT ATTDELKTVT KDRMEDIKIL IASPSPTHIH KETTSATSSP YRDTQSRTAS PNRAGKGVIE QTEKSHPRSP NVLSVALSQR TTVPEEELNP KILALQNAQR KRKMEHDGSL FQAVGIGTLL QQPDDHAATT SLSWKRVKGC KSSEQNGMEQ KTIILIPSDL ACRLLGQSMD ESGLPQLTSY DCEVNAPIQG SRNLLQGEEL LRALDQVN. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
HIF1A Human/重组人缺氧诱导因子-1α
产品编号：PRO-477
产品规格：10μg/50μg/1mg
Synonyms Hypoxia-inducible factor 1 alpha, HIF-1 alpha, HIF1 alpha, ARNT-interacting protein, Member of PAS protein 1, Basic-helix-loop-helix-PAS protein MOP1, HIF1A, MOP1, HIF1, PASD8, HIF-1A. Introduction Hypoxia-inducible factor-1 （HIF-1）, identified as one of the transcription factors, has been found to play an essential role in cellular ａnd systemic oxygen homeostasis. HIF-1 is a heterodimer composed of HIF-1? subunit ａnd one of three subunits （Hif-1?, Hif-2 （or Hif-3））. The activation of Hif-1 （is closely associated with a variety of tumors ａnd oncogenic pathways. Hif-1 （consists of DNA binding domain （DBD domain）, Dimerization domain ａnd C-terminal regulatory domains, including two transactivation domains （TAD）, an oxygen-dependent degradation （ODD） domain, ａnd inhibitory domains. Under hypoxic conditions HIF1A activates the transcription of more than 40 genes, including, erythropoietin, glucose transporters, glycolytic enzymes, VEGF, ａnd other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1A also plays a crucial role in embryonic vascularization, tumor angiogenesis ａnd pathophysiology of ischemic disease. It binds to core DNA sequence 5＇-[AG]CGTG-3＇ within the hypoxia response element （HRE） of target gene promoters. Activation involves recruitment of transcriptional coactivators such as CREBPB ａnd EP300. Its activity is improved by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX appears to activate CTAD ａnd potentiates activation by NCOA1 ａnd CREBBP. The induction is under reduced oxygen tension. HIF1A is also induced by a variety of receptor-mediated factors such as growth factors, cytokines, ａnd circulatory factors for example PDGF, EGF, FGF-2, IGF-2, TGF-1 beta, HGF, TNF alpha, IL-1 beta, angiotensin-2 ａnd thrombin. Nevertheless, this induction is less intense than that stimulated by hypoxia. Description HIF1A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 298 amino acids （530-826） ａnd having a molecular mass of 32.8 Dalton. The protein migrates as a 40kDa band on SDS-PAGE.
The HIF1-A is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile filtered liquid formulation. Formulation The HIF1A recombinant Human solution is formulated 20mM Tris-HCl pH-7.5 ａnd 1mM DTT. Stability MOP1 Recombinant Human although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days.
Please avoid freeze-thaw cycles. Amino Acid Sequence MEFKLELVEK LFAEDTEAKN PFSTQDTDLD LEMLAPYIPM DDDFQLRSFD QLSPLESSSA SPESASPQST VTVFQQTQIQ EPTANATTTT ATTDELKTVT KDRMEDIKIL IASPSPTHIH KETTSATSSP YRDTQSRTAS PNRAGKGVIE QTEKSHPRSP NVLSVALSQR TTVPEEELNP KILALQNAQR KRKMEHDGSL FQAVGIGTLL QQPDDHAATT SLSWKRVKGC KSSEQNGMEQ KTIILIPSDL ACRLLGQSMD ESGLPQLTSY DCEVNAPIQG SRNLLQGEEL LRALDQVN. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
HIF1A Human/重组人缺氧诱导因子-1α
产品编号：PRO-477
产品规格：10μg/50μg/1mg
Synonyms Hypoxia-inducible factor 1 alpha, HIF-1 alpha, HIF1 alpha, ARNT-interacting protein, Member of PAS protein 1, Basic-helix-loop-helix-PAS protein MOP1, HIF1A, MOP1, HIF1, PASD8, HIF-1A. Introduction Hypoxia-inducible factor-1 （HIF-1）, identified as one of the transcription factors, has been found to play an essential role in cellular ａnd systemic oxygen homeostasis. HIF-1 is a heterodimer composed of HIF-1? subunit ａnd one of three subunits （Hif-1?, Hif-2 （or Hif-3））. The activation of Hif-1 （is closely associated with a variety of tumors ａnd oncogenic pathways. Hif-1 （consists of DNA binding domain （DBD domain）, Dimerization domain ａnd C-terminal regulatory domains, including two transactivation domains （TAD）, an oxygen-dependent degradation （ODD） domain, ａnd inhibitory domains. Under hypoxic conditions HIF1A activates the transcription of more than 40 genes, including, erythropoietin, glucose transporters, glycolytic enzymes, VEGF, ａnd other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1A also plays a crucial role in embryonic vascularization, tumor angiogenesis ａnd pathophysiology of ischemic disease. It binds to core DNA sequence 5＇-[AG]CGTG-3＇ within the hypoxia response element （HRE） of target gene promoters. Activation involves recruitment of transcriptional coactivators such as CREBPB ａnd EP300. Its activity is improved by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX appears to activate CTAD ａnd potentiates activation by NCOA1 ａnd CREBBP. The induction is under reduced oxygen tension. HIF1A is also induced by a variety of receptor-mediated factors such as growth factors, cytokines, ａnd circulatory factors for example PDGF, EGF, FGF-2, IGF-2, TGF-1 beta, HGF, TNF alpha, IL-1 beta, angiotensin-2 ａnd thrombin. Nevertheless, this induction is less intense than that stimulated by hypoxia. Description HIF1A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 298 amino acids （530-826） ａnd having a molecular mass of 32.8 Dalton. The protein migrates as a 40kDa band on SDS-PAGE.
The HIF1-A is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile filtered liquid formulation. Formulation The HIF1A recombinant Human solution is formulated 20mM Tris-HCl pH-7.5 ａnd 1mM DTT. Stability MOP1 Recombinant Human although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days.
Please avoid freeze-thaw cycles. Amino Acid Sequence MEFKLELVEK LFAEDTEAKN PFSTQDTDLD LEMLAPYIPM DDDFQLRSFD QLSPLESSSA SPESASPQST VTVFQQTQIQ EPTANATTTT ATTDELKTVT KDRMEDIKIL IASPSPTHIH KETTSATSSP YRDTQSRTAS PNRAGKGVIE QTEKSHPRSP NVLSVALSQR TTVPEEELNP KILALQNAQR KRKMEHDGSL FQAVGIGTLL QQPDDHAATT SLSWKRVKGC KSSEQNGMEQ KTIILIPSDL ACRLLGQSMD ESGLPQLTSY DCEVNAPIQG SRNLLQGEEL LRALDQVN. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
HIF1A Human/重组人缺氧诱导因子-1α
产品编号：PRO-477
产品规格：10μg/50μg/1mg
Synonyms Hypoxia-inducible factor 1 alpha, HIF-1 alpha, HIF1 alpha, ARNT-interacting protein, Member of PAS protein 1, Basic-helix-loop-helix-PAS protein MOP1, HIF1A, MOP1, HIF1, PASD8, HIF-1A. Introduction Hypoxia-inducible factor-1 （HIF-1）, identified as one of the transcription factors, has been found to play an essential role in cellular ａnd systemic oxygen homeostasis. HIF-1 is a heterodimer composed of HIF-1? subunit ａnd one of three subunits （Hif-1?, Hif-2 （or Hif-3））. The activation of Hif-1 （is closely associated with a variety of tumors ａnd oncogenic pathways. Hif-1 （consists of DNA binding domain （DBD domain）, Dimerization domain ａnd C-terminal regulatory domains, including two transactivation domains （TAD）, an oxygen-dependent degradation （ODD） domain, ａnd inhibitory domains. Under hypoxic conditions HIF1A activates the transcription of more than 40 genes, including, erythropoietin, glucose transporters, glycolytic enzymes, VEGF, ａnd other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1A also plays a crucial role in embryonic vascularization, tumor angiogenesis ａnd pathophysiology of ischemic disease. It binds to core DNA sequence 5＇-[AG]CGTG-3＇ within the hypoxia response element （HRE） of target gene promoters. Activation involves recruitment of transcriptional coactivators such as CREBPB ａnd EP300. Its activity is improved by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX appears to activate CTAD ａnd potentiates activation by NCOA1 ａnd CREBBP. The induction is under reduced oxygen tension. HIF1A is also induced by a variety of receptor-mediated factors such as growth factors, cytokines, ａnd circulatory factors for example PDGF, EGF, FGF-2, IGF-2, TGF-1 beta, HGF, TNF alpha, IL-1 beta, angiotensin-2 ａnd thrombin. Nevertheless, this induction is less intense than that stimulated by hypoxia. Description HIF1A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 298 amino acids （530-826） ａnd having a molecular mass of 32.8 Dalton. The protein migrates as a 40kDa band on SDS-PAGE.
The HIF1-A is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile filtered liquid formulation. Formulation The HIF1A recombinant Human solution is formulated 20mM Tris-HCl pH-7.5 ａnd 1mM DTT. Stability MOP1 Recombinant Human although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days.
Please avoid freeze-thaw cycles. Amino Acid Sequence MEFKLELVEK LFAEDTEAKN PFSTQDTDLD LEMLAPYIPM DDDFQLRSFD QLSPLESSSA SPESASPQST VTVFQQTQIQ EPTANATTTT ATTDELKTVT KDRMEDIKIL IASPSPTHIH KETTSATSSP YRDTQSRTAS PNRAGKGVIE QTEKSHPRSP NVLSVALSQR TTVPEEELNP KILALQNAQR KRKMEHDGSL FQAVGIGTLL QQPDDHAATT SLSWKRVKGC KSSEQNGMEQ KTIILIPSDL ACRLLGQSMD ESGLPQLTSY DCEVNAPIQG SRNLLQGEEL LRALDQVN. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
HIF1A Human/重组人缺氧诱导因子-1α
产品编号：PRO-477
产品规格：10μg/50μg/1mg
Synonyms Hypoxia-inducible factor 1 alpha, HIF-1 alpha, HIF1 alpha, ARNT-interacting protein, Member of PAS protein 1, Basic-helix-loop-helix-PAS protein MOP1, HIF1A, MOP1, HIF1, PASD8, HIF-1A. Introduction Hypoxia-inducible factor-1 （HIF-1）, identified as one of the transcription factors, has been found to play an essential role in cellular ａnd systemic oxygen homeostasis. HIF-1 is a heterodimer composed of HIF-1? subunit ａnd one of three subunits （Hif-1?, Hif-2 （or Hif-3））. The activation of Hif-1 （is closely associated with a variety of tumors ａnd oncogenic pathways. Hif-1 （consists of DNA binding domain （DBD domain）, Dimerization domain ａnd C-terminal regulatory domains, including two transactivation domains （TAD）, an oxygen-dependent degradation （ODD） domain, ａnd inhibitory domains. Under hypoxic conditions HIF1A activates the transcription of more than 40 genes, including, erythropoietin, glucose transporters, glycolytic enzymes, VEGF, ａnd other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1A also plays a crucial role in embryonic vascularization, tumor angiogenesis ａnd pathophysiology of ischemic disease. It binds to core DNA sequence 5＇-[AG]CGTG-3＇ within the hypoxia response element （HRE） of target gene promoters. Activation involves recruitment of transcriptional coactivators such as CREBPB ａnd EP300. Its activity is improved by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX appears to activate CTAD ａnd potentiates activation by NCOA1 ａnd CREBBP. The induction is under reduced oxygen tension. HIF1A is also induced by a variety of receptor-mediated factors such as growth factors, cytokines, ａnd circulatory factors for example PDGF, EGF, FGF-2, IGF-2, TGF-1 beta, HGF, TNF alpha, IL-1 beta, angiotensin-2 ａnd thrombin. Nevertheless, this induction is less intense than that stimulated by hypoxia. Description HIF1A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 298 amino acids （530-826） ａnd having a molecular mass of 32.8 Dalton. The protein migrates as a 40kDa band on SDS-PAGE.
The HIF1-A is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile filtered liquid formulation. Formulation The HIF1A recombinant Human solution is formulated 20mM Tris-HCl pH-7.5 ａnd 1mM DTT. Stability MOP1 Recombinant Human although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days.
Please avoid freeze-thaw cycles. Amino Acid Sequence MEFKLELVEK LFAEDTEAKN PFSTQDTDLD LEMLAPYIPM DDDFQLRSFD QLSPLESSSA SPESASPQST VTVFQQTQIQ EPTANATTTT ATTDELKTVT KDRMEDIKIL IASPSPTHIH KETTSATSSP YRDTQSRTAS PNRAGKGVIE QTEKSHPRSP NVLSVALSQR TTVPEEELNP KILALQNAQR KRKMEHDGSL FQAVGIGTLL QQPDDHAATT SLSWKRVKGC KSSEQNGMEQ KTIILIPSDL ACRLLGQSMD ESGLPQLTSY DCEVNAPIQG SRNLLQGEEL LRALDQVN. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
HIF1A Human/重组人缺氧诱导因子-1α
产品编号：PRO-477
产品规格：10μg/50μg/1mg
Synonyms Hypoxia-inducible factor 1 alpha, HIF-1 alpha, HIF1 alpha, ARNT-interacting protein, Member of PAS protein 1, Basic-helix-loop-helix-PAS protein MOP1, HIF1A, MOP1, HIF1, PASD8, HIF-1A. Introduction Hypoxia-inducible factor-1 （HIF-1）, identified as one of the transcription factors, has been found to play an essential role in cellular ａnd systemic oxygen homeostasis. HIF-1 is a heterodimer composed of HIF-1? subunit ａnd one of three subunits （Hif-1?, Hif-2 （or Hif-3））. The activation of Hif-1 （is closely associated with a variety of tumors ａnd oncogenic pathways. Hif-1 （consists of DNA binding domain （DBD domain）, Dimerization domain ａnd C-terminal regulatory domains, including two transactivation domains （TAD）, an oxygen-dependent degradation （ODD） domain, ａnd inhibitory domains. Under hypoxic conditions HIF1A activates the transcription of more than 40 genes, including, erythropoietin, glucose transporters, glycolytic enzymes, VEGF, ａnd other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1A also plays a crucial role in embryonic vascularization, tumor angiogenesis ａnd pathophysiology of ischemic disease. It binds to core DNA sequence 5＇-[AG]CGTG-3＇ within the hypoxia response element （HRE） of target gene promoters. Activation involves recruitment of transcriptional coactivators such as CREBPB ａnd EP300. Its activity is improved by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX appears to activate CTAD ａnd potentiates activation by NCOA1 ａnd CREBBP. The induction is under reduced oxygen tension. HIF1A is also induced by a variety of receptor-mediated factors such as growth factors, cytokines, ａnd circulatory factors for example PDGF, EGF, FGF-2, IGF-2, TGF-1 beta, HGF, TNF alpha, IL-1 beta, angiotensin-2 ａnd thrombin. Nevertheless, this induction is less intense than that stimulated by hypoxia. Description HIF1A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 298 amino acids （530-826） ａnd having a molecular mass of 32.8 Dalton. The protein migrates as a 40kDa band on SDS-PAGE.
The HIF1-A is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile filtered liquid formulation. Formulation The HIF1A recombinant Human solution is formulated 20mM Tris-HCl pH-7.5 ａnd 1mM DTT. Stability MOP1 Recombinant Human although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days.
Please avoid freeze-thaw cycles. Amino Acid Sequence MEFKLELVEK LFAEDTEAKN PFSTQDTDLD LEMLAPYIPM DDDFQLRSFD QLSPLESSSA SPESASPQST VTVFQQTQIQ EPTANATTTT ATTDELKTVT KDRMEDIKIL IASPSPTHIH KETTSATSSP YRDTQSRTAS PNRAGKGVIE QTEKSHPRSP NVLSVALSQR TTVPEEELNP KILALQNAQR KRKMEHDGSL FQAVGIGTLL QQPDDHAATT SLSWKRVKGC KSSEQNGMEQ KTIILIPSDL ACRLLGQSMD ESGLPQLTSY DCEVNAPIQG SRNLLQGEEL LRALDQVN. Purity Greater than 95.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
产品规格：10μg/50μg/1mg
| Synonyms | Hypoxia-inducible factor 1 alpha, HIF-1 alpha, HIF1 alpha, ARNT-interacting protein, Member of PAS protein 1, Basic-helix-loop-helix-PAS protein MOP1, HIF1A, MOP1, HIF1, PASD8, HIF-1A. |
| Introduction | Hypoxia-inducible factor-1 （HIF-1）, identified as one of the transcription factors, has been found to play an essential role in cellular ａnd systemic oxygen homeostasis. HIF-1 is a heterodimer composed of HIF-1? subunit ａnd one of three subunits （Hif-1?, Hif-2 （or Hif-3））. The activation of Hif-1 （is closely associated with a variety of tumors ａnd oncogenic pathways. Hif-1 （consists of DNA binding domain （DBD domain）, Dimerization domain ａnd C-terminal regulatory domains, including two transactivation domains （TAD）, an oxygen-dependent degradation （ODD） domain, ａnd inhibitory domains. Under hypoxic conditions HIF1A activates the transcription of more than 40 genes, including, erythropoietin, glucose transporters, glycolytic enzymes, VEGF, ａnd other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1A also plays a crucial role in embryonic vascularization, tumor angiogenesis ａnd pathophysiology of ischemic disease. It binds to core DNA sequence 5＇-[AG]CGTG-3＇ within the hypoxia response element （HRE） of target gene promoters. Activation involves recruitment of transcriptional coactivators such as CREBPB ａnd EP300. Its activity is improved by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX appears to activate CTAD ａnd potentiates activation by NCOA1 ａnd CREBBP. The induction is under reduced oxygen tension. HIF1A is also induced by a variety of receptor-mediated factors such as growth factors, cytokines, ａnd circulatory factors for example PDGF, EGF, FGF-2, IGF-2, TGF-1 beta, HGF, TNF alpha, IL-1 beta, angiotensin-2 ａnd thrombin. Nevertheless, this induction is less intense than that stimulated by hypoxia. |
| Description | HIF1A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 298 amino acids （530-826） ａnd having a molecular mass of 32.8 Dalton. The protein migrates as a 40kDa band on SDS-PAGE. The HIF1-A is purified by proprietary chromatographic techniques. |
| Source | Escherichia Coli. |
| Physical Appearance | Sterile filtered liquid formulation. |
| Formulation | The HIF1A recombinant Human solution is formulated 20mM Tris-HCl pH-7.5 ａnd 1mM DTT. |
| Stability | MOP1 Recombinant Human although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days. Please avoid freeze-thaw cycles. |
| Amino Acid Sequence | MEFKLELVEK LFAEDTEAKN PFSTQDTDLD LEMLAPYIPM DDDFQLRSFD QLSPLESSSA SPESASPQST VTVFQQTQIQ EPTANATTTT ATTDELKTVT KDRMEDIKIL IASPSPTHIH KETTSATSSP YRDTQSRTAS PNRAGKGVIE QTEKSHPRSP NVLSVALSQR TTVPEEELNP KILALQNAQR KRKMEHDGSL FQAVGIGTLL QQPDDHAATT SLSWKRVKGC KSSEQNGMEQ KTIILIPSDL ACRLLGQSMD ESGLPQLTSY DCEVNAPIQG SRNLLQGEEL LRALDQVN. |
| Purity | Greater than 95.0% as determined by（a） Analysis by RP-HPLC. （b） Analysis by SDS-PAGE. |
| Usage | Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
