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重组人内皮抑素/Endostatin Human
点击次数：114发布时间：2012/9/12 22:40:05
更新日期：2024/10/16 16:00:19
所 在 地：美洲
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重组人内皮抑素/Endostatin Human
产品编号：PRO-248
产品规格：20ug/100ug/1mg
产品规格：20ug/100ug/1mg
Catalogue NumberPRO-248IntroductionOnce a cluster of cancer cells reaches a diameter of about 1–2 mm, it must develop a blood supply in order to grow larger. Given that diffusion is no longer adequate to supply the cancerous cells with oxygen ａnd nutrients ａnd to remove wastes. Therefore, these cells secrete substances that promote the formation of new blood vessels （angiogenesis）, which are vital for the growth ａnd persistence of solid tumors ａnd their metastases.
The production of several angiogenic factors （FGF-a, FGF-b, VEGF ａnd VPF） is upregulated by tumors in order to stimulate angiogenesis. However, numerous malignant tumors also generate inhibitors of angiogenesis which include angiostatin ａnd thrombospondin. The angiogenic phenotype is basically the end result of a net balance between the positive ａnd negative regulators of neovascularization mentioned above. Endostatin’s role is to inhibit endothelial proliferation, therefore it is an effective angiogenesis inhibitor.DescriptionEndostatin Human Recombinant produced in Pichia Pastoris is a single, non-glycosylated, polypeptide having a total molecular mass of 20,000 Dalton C-terminal fragment of collagen XVIII that has been shown to act as a potent inhibitor of angiogenesis ａnd tumor growth in vitro ａnd in vivo. Induces tyrosine phosphorylation of Shc （SH2 domain adapter protein） leading to specific inhibition in endothelial cell prolifiration.
The Endostatin is fused to His tag at N-terminus ａnd purified by proprietary chromatographic techniques.SourcePichia Pastoris.Physical AppearanceSterile filtered liquid formulation.FormulationThe recombinant Human Endostatin is formulated with PBS.StabilityEndostatin although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days.
Please avoid Freeze/Thaw cycles.PurityGreater than 98.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE.Amino Acid CompositionIn total agreement with the expected amino acid composition of native human Endostatin.Biological ActivityThe activity calculated by ECE migration inhibition was found to be 50,000IU/mg.ReferencesTitle:Arteriosclerosis, Thrombosis, ａnd Vascular Biology.
Publication:ISSN: 1524-4636Copyright ? 2010 American Heart Association. All rights reserved. Print ISSN: 1079-5642. Online7272 Greenville Avenue, Dallas, TX 72514.
Link:http://atvb.ahajournals.org/content/30/6/1220.full.pdf
UsageProspec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
The production of several angiogenic factors （FGF-a, FGF-b, VEGF ａnd VPF） is upregulated by tumors in order to stimulate angiogenesis. However, numerous malignant tumors also generate inhibitors of angiogenesis which include angiostatin ａnd thrombospondin. The angiogenic phenotype is basically the end result of a net balance between the positive ａnd negative regulators of neovascularization mentioned above. Endostatin’s role is to inhibit endothelial proliferation, therefore it is an effective angiogenesis inhibitor.DescriptionEndostatin Human Recombinant produced in Pichia Pastoris is a single, non-glycosylated, polypeptide having a total molecular mass of 20,000 Dalton C-terminal fragment of collagen XVIII that has been shown to act as a potent inhibitor of angiogenesis ａnd tumor growth in vitro ａnd in vivo. Induces tyrosine phosphorylation of Shc （SH2 domain adapter protein） leading to specific inhibition in endothelial cell prolifiration.
The Endostatin is fused to His tag at N-terminus ａnd purified by proprietary chromatographic techniques.SourcePichia Pastoris.Physical AppearanceSterile filtered liquid formulation.FormulationThe recombinant Human Endostatin is formulated with PBS.StabilityEndostatin although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days.
Please avoid Freeze/Thaw cycles.PurityGreater than 98.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE.Amino Acid CompositionIn total agreement with the expected amino acid composition of native human Endostatin.Biological ActivityThe activity calculated by ECE migration inhibition was found to be 50,000IU/mg.ReferencesTitle:Arteriosclerosis, Thrombosis, ａnd Vascular Biology.
Publication:ISSN: 1524-4636Copyright ? 2010 American Heart Association. All rights reserved. Print ISSN: 1079-5642. Online7272 Greenville Avenue, Dallas, TX 72514.
Link:http://atvb.ahajournals.org/content/30/6/1220.full.pdf
UsageProspec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
