产品展示
优质供应
详细内容
重组人DIRAS1/DIRAS1 Human
产品编号：PRO-256
产品规格：2ug/10ug/1mg
产品规格：2ug/10ug/1mg
| Catalogue Number | PRO-256 |
| Synonyms | GTP-binding protein Di-Ras1, Distinct subgroup of the Ras family member 1, Ras-related inhibitor of cell growth, Rig, Small GTP-binding tumor suppressor 1, DIRAS1, GBTS1, Di-Ras1, FLJ42681. |
| Introduction | DIRAS1 is a member of a distinct branch of the functionally diverse Ras superfamily of monomeric GTPases. DIRAS1 demonstrates low GTPase activity ａnd exists mainly in the GTP-bound form. Ras proteins operate as binary molecular switches that control intracellular signaling networks. Ras-regulated signal pathways regulate such processes as actin cytoskeletal integrity, proliferation, differentiation, cell adhesion, apoptosis, ａnd cell migration. Ras ａnd ras-related proteins are frequently deregulated in cancers, leading to increased invasion ａnd metastasis, ａnd decreased apoptosis. |
| Description | DIRAS1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 215 amino acids （1-195a.a.） ａnd having a molecular mass of 24.1 kDa. DIRAS1 protein is fused to a 20 amino acid His tag at N-terminus ａnd is purified by standard chromatography. |
| Source | Escherichia Coli. |
| Physical Appearance | Sterile filtered colorless solution. |
| Formulation | DIRAS1 Human solution （1mg/ml） containing 20mM Tris-HCl buffer（pH 8.0） containing 20% glycerol, 1mM DTT, 0.1M NaCl ａnd 1mM EDTA. |
| Stability | DIRAS1 Human although stable at 4°C for 1 week, should be stored desiccated below -18°C. Please prevent freeze thaw cycles. |
| Amino acid sequence | MGSSHHHHHH SSGLVPRGSH MPEQSNDYRV VVFGAGGVGK SSLVLRFVKG TFRDTYIPTI EDTYRQVISC DKSVCTLQIT DTTGSHQFPA MQRLSISKGH AFILVFSVTS KQSLEELGPI YKLIVQIKGS VEDIPVMLVG KCDETQREV DTREAQAVAQ EWKCAFMETS AKMNYNVKEL FQELLTLETR RNMSLNIDGK RSGKQKRTDR KGKC. |
| Purity | Greater than 95% as determined by SDS-PAGE. |
| Usage | ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
