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重组人V-CRK肉瘤病毒癌基因CT10/CRK Human
点击次数：136发布时间：2012/9/13 9:00:00
更新日期：2024/10/16 16:00:19
所 在 地：美洲
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重组人V-CRK肉瘤病毒癌基因CT10/CRK Human
产品编号：PRO-275
产品规格：1ug/5ug/50ug
产品规格：1ug/5ug/50ug
| Catalogue Number | PRO-275 |
| Synonyms | Adapter molecule crk, Proto-oncogene c-Crk, p38, CRK, CRKII. |
| Introduction | CRK belongs to the signaling adapter protein family which binds to several tyrosine-phosphorylated proteins. CRK is involved in many cellular processes such as apoptosis, proliferation, ａnd differentiation. CRK has a modular domain architecture consisting of an SH2 followed by two SH3 domains （src-homology domains）. The N-terminal SH2 domain of the CRK protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. |
| Description | CRK Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 224 amino acids （1-204 a.a.） ａnd having a molecular mass of 25kDa. The CRK is purified by proprietary chromatographic techniques. |
| Source | Escherichia Coli. |
| Physical Appearance | Sterile Filtered colorless solution. |
| Formulation | The CRK solution （0.5 mg/ml） contains 20mM Tris-HCl Buffer （pH 8.0） ａnd 10% Glycerol. |
| Stability | CRK should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles. |
| Purity | Greater than 95.0% as determined by SDS-PAGE. |
| Amino acid sequence | MGSSHHHHHH SSGLVPRGSH MAGNFDSEER SSWYWGRLSR QEAVALLQGQ RHGVFLVRDS STSPGDYVLS VSENSRVSHY IINSSGPRPP VPPSPAQPPP GVSPSRLRIG DQEFDSLPAL LEFYKIHYLD TTTLIEPVSR SRQGSGVILR QEEAEYVRAL FDFNGNDEED LPFKKGDILR IRDKPEEQWW NAEDSEGKRG MIPVPYVEKY RPASASVSAL IGGR. |
| Usage | ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
