产品展示
人甲状腺球蛋白/Thyroglobulin Human
点击次数：167发布时间：2012/9/13 9:19:25
更新日期：2024/10/16 16:00:19
所 在 地：美洲
产品型号：
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详细内容
人甲状腺球蛋白/Thyroglobulin Human
产品编号：PRO-443
产品规格：20μg/100μg/1mg
产品规格：20μg/100μg/1mg
| Catalogue Number | PRO-443 |
| Synonyms | Thyroglobulin, TGN, AITD3, TG. |
| Introduction | Thyroglobulin （TG） represents one of the main autoantigenic targets in autoimmune thyroid disease of humans. TG is a large globular dimeric glycoprotein with a total molecular weight of 660 kDa, which occupies a key precursor role in the biosynthesis of the thyroid hormones. Approximately 75% of the total protein content of the thyroid follicle consists of TG. The thyroid gland uses the Thyroglobulin in order to produce the thyroid hormones thyroxine （T4） ａnd triiodothyronine （T3）. Thyroglobulin is produced by the thyroid epithelial cells （thyrocytes） which form spherical follicles. Thyroglobulin is subsequently secreted ａnd stored in the follicular lumen. Patients with Hashimoto＇s thyroiditis or Graves＇ disease, frequently develop antibodies against Thyroglobulin. Tg-specific antibodies help in the diagnosis of the above diseases, however they also may be present in apparently healthy euthyroid individuals. Blood Thyroglobulin levels can be used as a tumor marker for certain kinds of thyroid cancer, ａnd the may also be elevated in cases of Graves＇ disease. |
| Description | Human Thyroglobulin is a glycosylated, polypeptide chain having a total molecular mass of 662 kDa （331 kDa per subunit）. |
| Source | Native, Isolated from human thyroid glands. |
| Physical Appearance | Sterile Filtered solution. |
| Formulation | Human Thyroglobulin is supplied in 16mM HEPES buffer pH-7.6, 240mM sodium chloride, ａnd 20% glycerol. |
| Storage Conditions | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Purity | Greater than 95% as determined by SDS-PAGE. |
| Usage | Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
