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重组人Fas相关死亡结构域/FADD Human
点击次数：141发布时间：2012/9/13 14:35:26
更新日期：2024/10/16 16:00:19
所 在 地：美洲
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重组人Fas相关死亡结构域/FADD Human
产品编号：PRO-733
产品规格：2μg/10μg/1mg
产品规格：2μg/10μg/1mg
| Catalogue Number | PRO-733 |
| Synonyms | GIG3, MORT1, MGC8528, FADD, Fas （TNFRSF6）-associated via death domain, Protein FADD, FAS-associated death domain protein, FAS-associating death domain-containing protein, Mediator of receptor induced toxicity, Growth-inhibiting gene 3 protein. |
| Introduction | FADD is an adaptor protein that cooperates with a variety of cell surface receptors ａnd mediates cell apoptotic signals. Using its C-terminal death domain, FADD is recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, ａnd TNFSF10/TRAIL-receptor, ａnd consequently it take parts in the death signaling initiated by these receptors. FADD interaction with the receptors reviels the N-terminal effector domain of, which allows it to recruit caspase-8, ａnd thus initiate the cysteine protease cascade. Knockout studies in mice furthermore propose the significance of FADD in premature T cell development. FADD plays a role in survival/proliferation ａnd cell cycle development. FADD also takes part in cellular sublocalization, protein phosphorylation, ａnd inhibitory molecules. |
| Description | FADD produced in E.Coli is a single, non-glycosylated polypeptide chain containing 244 amino acids （1-208 a.a.） ａnd having a molecular mass of 27.4 kDa. FADD is fused to 36 amino acid His-Tag at N-terminus ａnd purified by proprietary chromatographic techniques. |
| Source | Escherichia Coli. |
| Physical Appearance | Sterile filtered colorless solution. |
| Formulation | The FADD protein solution contains 20mM Tris-HCl, pH-8, ａnd 10% glycerol. |
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Avoid multiple freeze-thaw cycles. |
| Purity | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence | MRGSHHHHHHGMASMTGGQQ MGRDLYDDDD KDRWGSMDPF LVLLHSVSSS LSSSELTELK FLCLGRVGKR KLERVQSGLD LFSMLLEQND LEPGHTELLR ELLASLRRHD LLRRVDDFEA GAAAGAAPGE EDLCAAFNVI CDNVGKDWRR LARQLKVSDT KIDSIEDRYP RNLTERVRES LRIWKNTEKE NATVAHLVGA LRSCQMNLVA DLVQEVQQAR DLQNRSGAMS PMSWNSDAST SEAS. |
| Usage | ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
