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Factor VIII RA Human/重组人因子VIII相关抗原
产品编号：PRO-502
产品规格：2μg/5μg/10μg
Synonyms von Willebrand factor, vWF, F8VWF, VWD, Factor VIII Related Antigen, Factor-VIII RA. Introduction Factor VIII related antigen or von Willebrand factor is a multimeric glycoprotein. It has functional binding domains to platelet glycoprotein Ib, glycoprotein IIb/IIIa, collagen ａnd heparin. von Willebrand factor is synthesized by endothelial cells ａnd stored in the Weibel-Palade granules. It mediates platelet adhesion to injured vessel walls ａnd serves as a carrier ａnd stabilizer for coagulation factor VIII. von Willebrand factor is one of the most useful markers to identify endothelial （or megakaryocytic） lineage of neoplasms. As not all endothelial cells synthesize / store） this molecule, about 30% of tumors of vascular origin fail to stain for factor VIII related antigen, regardless of whether they are benign or malignant. Staining for factor VIII related antigen has also been used to measure angiogenesis, an indicator of tumor recurrence. vWF functions as both an antihemophilic factor carrier ａnd a platelet-vessel wall mediator in the blood coagulation system. vWF is critical to the hemostasis process. vWF is deficient or defective in von Willebrand disease ａnd is involved in a large number of other diseases, including thrombotic thrombocytopenic purpura, Heyde＇s syndrome, ａnd possibly hemolytic-uremic syndrome.
vWF is produced constitutively in the endothelium （in the Weibel-Palade bodies）, in the megakaryocytes （?-granules of platelets）, ａnd in the subendothelial connective tissue. Since Von Willebrand factor is not an enzyme it has no catalytic activity. vWF’s principal function is binding to other proteins, mainly to Factor VIII ａnd it is essential in platelet adhesion to wound sites. Factor VIII is attached to vWF while inactive in the circulation. Factor VIII degrades quickly when not attached to vWF. Description Factor VIII Related Antigen Human Recombinant （aa 2597-2791） expressed in E.coli, shows a 48 kDa band on SDS-PAGE.
The Factor-VIII RA is fused to GST-Tag ａnd purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation Factor VIII Related Antigen in 50mM Tris-Acetate, pH7.5, 1mM EDTA ａnd 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Factor VIII RA Human/重组人因子VIII相关抗原
产品编号：PRO-502
产品规格：2μg/5μg/10μg
Synonyms von Willebrand factor, vWF, F8VWF, VWD, Factor VIII Related Antigen, Factor-VIII RA. Introduction Factor VIII related antigen or von Willebrand factor is a multimeric glycoprotein. It has functional binding domains to platelet glycoprotein Ib, glycoprotein IIb/IIIa, collagen ａnd heparin. von Willebrand factor is synthesized by endothelial cells ａnd stored in the Weibel-Palade granules. It mediates platelet adhesion to injured vessel walls ａnd serves as a carrier ａnd stabilizer for coagulation factor VIII. von Willebrand factor is one of the most useful markers to identify endothelial （or megakaryocytic） lineage of neoplasms. As not all endothelial cells synthesize / store） this molecule, about 30% of tumors of vascular origin fail to stain for factor VIII related antigen, regardless of whether they are benign or malignant. Staining for factor VIII related antigen has also been used to measure angiogenesis, an indicator of tumor recurrence. vWF functions as both an antihemophilic factor carrier ａnd a platelet-vessel wall mediator in the blood coagulation system. vWF is critical to the hemostasis process. vWF is deficient or defective in von Willebrand disease ａnd is involved in a large number of other diseases, including thrombotic thrombocytopenic purpura, Heyde＇s syndrome, ａnd possibly hemolytic-uremic syndrome.
vWF is produced constitutively in the endothelium （in the Weibel-Palade bodies）, in the megakaryocytes （?-granules of platelets）, ａnd in the subendothelial connective tissue. Since Von Willebrand factor is not an enzyme it has no catalytic activity. vWF’s principal function is binding to other proteins, mainly to Factor VIII ａnd it is essential in platelet adhesion to wound sites. Factor VIII is attached to vWF while inactive in the circulation. Factor VIII degrades quickly when not attached to vWF. Description Factor VIII Related Antigen Human Recombinant （aa 2597-2791） expressed in E.coli, shows a 48 kDa band on SDS-PAGE.
The Factor-VIII RA is fused to GST-Tag ａnd purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation Factor VIII Related Antigen in 50mM Tris-Acetate, pH7.5, 1mM EDTA ａnd 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Factor VIII RA Human/重组人因子VIII相关抗原
产品编号：PRO-502
产品规格：2μg/5μg/10μg
Synonyms von Willebrand factor, vWF, F8VWF, VWD, Factor VIII Related Antigen, Factor-VIII RA. Introduction Factor VIII related antigen or von Willebrand factor is a multimeric glycoprotein. It has functional binding domains to platelet glycoprotein Ib, glycoprotein IIb/IIIa, collagen ａnd heparin. von Willebrand factor is synthesized by endothelial cells ａnd stored in the Weibel-Palade granules. It mediates platelet adhesion to injured vessel walls ａnd serves as a carrier ａnd stabilizer for coagulation factor VIII. von Willebrand factor is one of the most useful markers to identify endothelial （or megakaryocytic） lineage of neoplasms. As not all endothelial cells synthesize / store） this molecule, about 30% of tumors of vascular origin fail to stain for factor VIII related antigen, regardless of whether they are benign or malignant. Staining for factor VIII related antigen has also been used to measure angiogenesis, an indicator of tumor recurrence. vWF functions as both an antihemophilic factor carrier ａnd a platelet-vessel wall mediator in the blood coagulation system. vWF is critical to the hemostasis process. vWF is deficient or defective in von Willebrand disease ａnd is involved in a large number of other diseases, including thrombotic thrombocytopenic purpura, Heyde＇s syndrome, ａnd possibly hemolytic-uremic syndrome.
vWF is produced constitutively in the endothelium （in the Weibel-Palade bodies）, in the megakaryocytes （?-granules of platelets）, ａnd in the subendothelial connective tissue. Since Von Willebrand factor is not an enzyme it has no catalytic activity. vWF’s principal function is binding to other proteins, mainly to Factor VIII ａnd it is essential in platelet adhesion to wound sites. Factor VIII is attached to vWF while inactive in the circulation. Factor VIII degrades quickly when not attached to vWF. Description Factor VIII Related Antigen Human Recombinant （aa 2597-2791） expressed in E.coli, shows a 48 kDa band on SDS-PAGE.
The Factor-VIII RA is fused to GST-Tag ａnd purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation Factor VIII Related Antigen in 50mM Tris-Acetate, pH7.5, 1mM EDTA ａnd 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Factor VIII RA Human/重组人因子VIII相关抗原
产品编号：PRO-502
产品规格：2μg/5μg/10μg
Synonyms von Willebrand factor, vWF, F8VWF, VWD, Factor VIII Related Antigen, Factor-VIII RA. Introduction Factor VIII related antigen or von Willebrand factor is a multimeric glycoprotein. It has functional binding domains to platelet glycoprotein Ib, glycoprotein IIb/IIIa, collagen ａnd heparin. von Willebrand factor is synthesized by endothelial cells ａnd stored in the Weibel-Palade granules. It mediates platelet adhesion to injured vessel walls ａnd serves as a carrier ａnd stabilizer for coagulation factor VIII. von Willebrand factor is one of the most useful markers to identify endothelial （or megakaryocytic） lineage of neoplasms. As not all endothelial cells synthesize / store） this molecule, about 30% of tumors of vascular origin fail to stain for factor VIII related antigen, regardless of whether they are benign or malignant. Staining for factor VIII related antigen has also been used to measure angiogenesis, an indicator of tumor recurrence. vWF functions as both an antihemophilic factor carrier ａnd a platelet-vessel wall mediator in the blood coagulation system. vWF is critical to the hemostasis process. vWF is deficient or defective in von Willebrand disease ａnd is involved in a large number of other diseases, including thrombotic thrombocytopenic purpura, Heyde＇s syndrome, ａnd possibly hemolytic-uremic syndrome.
vWF is produced constitutively in the endothelium （in the Weibel-Palade bodies）, in the megakaryocytes （?-granules of platelets）, ａnd in the subendothelial connective tissue. Since Von Willebrand factor is not an enzyme it has no catalytic activity. vWF’s principal function is binding to other proteins, mainly to Factor VIII ａnd it is essential in platelet adhesion to wound sites. Factor VIII is attached to vWF while inactive in the circulation. Factor VIII degrades quickly when not attached to vWF. Description Factor VIII Related Antigen Human Recombinant （aa 2597-2791） expressed in E.coli, shows a 48 kDa band on SDS-PAGE.
The Factor-VIII RA is fused to GST-Tag ａnd purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation Factor VIII Related Antigen in 50mM Tris-Acetate, pH7.5, 1mM EDTA ａnd 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Factor VIII RA Human/重组人因子VIII相关抗原
产品编号：PRO-502
产品规格：2μg/5μg/10μg
Synonyms von Willebrand factor, vWF, F8VWF, VWD, Factor VIII Related Antigen, Factor-VIII RA. Introduction Factor VIII related antigen or von Willebrand factor is a multimeric glycoprotein. It has functional binding domains to platelet glycoprotein Ib, glycoprotein IIb/IIIa, collagen ａnd heparin. von Willebrand factor is synthesized by endothelial cells ａnd stored in the Weibel-Palade granules. It mediates platelet adhesion to injured vessel walls ａnd serves as a carrier ａnd stabilizer for coagulation factor VIII. von Willebrand factor is one of the most useful markers to identify endothelial （or megakaryocytic） lineage of neoplasms. As not all endothelial cells synthesize / store） this molecule, about 30% of tumors of vascular origin fail to stain for factor VIII related antigen, regardless of whether they are benign or malignant. Staining for factor VIII related antigen has also been used to measure angiogenesis, an indicator of tumor recurrence. vWF functions as both an antihemophilic factor carrier ａnd a platelet-vessel wall mediator in the blood coagulation system. vWF is critical to the hemostasis process. vWF is deficient or defective in von Willebrand disease ａnd is involved in a large number of other diseases, including thrombotic thrombocytopenic purpura, Heyde＇s syndrome, ａnd possibly hemolytic-uremic syndrome.
vWF is produced constitutively in the endothelium （in the Weibel-Palade bodies）, in the megakaryocytes （?-granules of platelets）, ａnd in the subendothelial connective tissue. Since Von Willebrand factor is not an enzyme it has no catalytic activity. vWF’s principal function is binding to other proteins, mainly to Factor VIII ａnd it is essential in platelet adhesion to wound sites. Factor VIII is attached to vWF while inactive in the circulation. Factor VIII degrades quickly when not attached to vWF. Description Factor VIII Related Antigen Human Recombinant （aa 2597-2791） expressed in E.coli, shows a 48 kDa band on SDS-PAGE.
The Factor-VIII RA is fused to GST-Tag ａnd purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation Factor VIII Related Antigen in 50mM Tris-Acetate, pH7.5, 1mM EDTA ａnd 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Factor VIII RA Human/重组人因子VIII相关抗原
产品编号：PRO-502
产品规格：2μg/5μg/10μg
Synonyms von Willebrand factor, vWF, F8VWF, VWD, Factor VIII Related Antigen, Factor-VIII RA. Introduction Factor VIII related antigen or von Willebrand factor is a multimeric glycoprotein. It has functional binding domains to platelet glycoprotein Ib, glycoprotein IIb/IIIa, collagen ａnd heparin. von Willebrand factor is synthesized by endothelial cells ａnd stored in the Weibel-Palade granules. It mediates platelet adhesion to injured vessel walls ａnd serves as a carrier ａnd stabilizer for coagulation factor VIII. von Willebrand factor is one of the most useful markers to identify endothelial （or megakaryocytic） lineage of neoplasms. As not all endothelial cells synthesize / store） this molecule, about 30% of tumors of vascular origin fail to stain for factor VIII related antigen, regardless of whether they are benign or malignant. Staining for factor VIII related antigen has also been used to measure angiogenesis, an indicator of tumor recurrence. vWF functions as both an antihemophilic factor carrier ａnd a platelet-vessel wall mediator in the blood coagulation system. vWF is critical to the hemostasis process. vWF is deficient or defective in von Willebrand disease ａnd is involved in a large number of other diseases, including thrombotic thrombocytopenic purpura, Heyde＇s syndrome, ａnd possibly hemolytic-uremic syndrome.
vWF is produced constitutively in the endothelium （in the Weibel-Palade bodies）, in the megakaryocytes （?-granules of platelets）, ａnd in the subendothelial connective tissue. Since Von Willebrand factor is not an enzyme it has no catalytic activity. vWF’s principal function is binding to other proteins, mainly to Factor VIII ａnd it is essential in platelet adhesion to wound sites. Factor VIII is attached to vWF while inactive in the circulation. Factor VIII degrades quickly when not attached to vWF. Description Factor VIII Related Antigen Human Recombinant （aa 2597-2791） expressed in E.coli, shows a 48 kDa band on SDS-PAGE.
The Factor-VIII RA is fused to GST-Tag ａnd purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation Factor VIII Related Antigen in 50mM Tris-Acetate, pH7.5, 1mM EDTA ａnd 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Factor VIII RA Human/重组人因子VIII相关抗原
产品编号：PRO-502
产品规格：2μg/5μg/10μg
Synonyms von Willebrand factor, vWF, F8VWF, VWD, Factor VIII Related Antigen, Factor-VIII RA. Introduction Factor VIII related antigen or von Willebrand factor is a multimeric glycoprotein. It has functional binding domains to platelet glycoprotein Ib, glycoprotein IIb/IIIa, collagen ａnd heparin. von Willebrand factor is synthesized by endothelial cells ａnd stored in the Weibel-Palade granules. It mediates platelet adhesion to injured vessel walls ａnd serves as a carrier ａnd stabilizer for coagulation factor VIII. von Willebrand factor is one of the most useful markers to identify endothelial （or megakaryocytic） lineage of neoplasms. As not all endothelial cells synthesize / store） this molecule, about 30% of tumors of vascular origin fail to stain for factor VIII related antigen, regardless of whether they are benign or malignant. Staining for factor VIII related antigen has also been used to measure angiogenesis, an indicator of tumor recurrence. vWF functions as both an antihemophilic factor carrier ａnd a platelet-vessel wall mediator in the blood coagulation system. vWF is critical to the hemostasis process. vWF is deficient or defective in von Willebrand disease ａnd is involved in a large number of other diseases, including thrombotic thrombocytopenic purpura, Heyde＇s syndrome, ａnd possibly hemolytic-uremic syndrome.
vWF is produced constitutively in the endothelium （in the Weibel-Palade bodies）, in the megakaryocytes （?-granules of platelets）, ａnd in the subendothelial connective tissue. Since Von Willebrand factor is not an enzyme it has no catalytic activity. vWF’s principal function is binding to other proteins, mainly to Factor VIII ａnd it is essential in platelet adhesion to wound sites. Factor VIII is attached to vWF while inactive in the circulation. Factor VIII degrades quickly when not attached to vWF. Description Factor VIII Related Antigen Human Recombinant （aa 2597-2791） expressed in E.coli, shows a 48 kDa band on SDS-PAGE.
The Factor-VIII RA is fused to GST-Tag ａnd purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation Factor VIII Related Antigen in 50mM Tris-Acetate, pH7.5, 1mM EDTA ａnd 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Factor VIII RA Human/重组人因子VIII相关抗原
产品编号：PRO-502
产品规格：2μg/5μg/10μg
Synonyms von Willebrand factor, vWF, F8VWF, VWD, Factor VIII Related Antigen, Factor-VIII RA. Introduction Factor VIII related antigen or von Willebrand factor is a multimeric glycoprotein. It has functional binding domains to platelet glycoprotein Ib, glycoprotein IIb/IIIa, collagen ａnd heparin. von Willebrand factor is synthesized by endothelial cells ａnd stored in the Weibel-Palade granules. It mediates platelet adhesion to injured vessel walls ａnd serves as a carrier ａnd stabilizer for coagulation factor VIII. von Willebrand factor is one of the most useful markers to identify endothelial （or megakaryocytic） lineage of neoplasms. As not all endothelial cells synthesize / store） this molecule, about 30% of tumors of vascular origin fail to stain for factor VIII related antigen, regardless of whether they are benign or malignant. Staining for factor VIII related antigen has also been used to measure angiogenesis, an indicator of tumor recurrence. vWF functions as both an antihemophilic factor carrier ａnd a platelet-vessel wall mediator in the blood coagulation system. vWF is critical to the hemostasis process. vWF is deficient or defective in von Willebrand disease ａnd is involved in a large number of other diseases, including thrombotic thrombocytopenic purpura, Heyde＇s syndrome, ａnd possibly hemolytic-uremic syndrome.
vWF is produced constitutively in the endothelium （in the Weibel-Palade bodies）, in the megakaryocytes （?-granules of platelets）, ａnd in the subendothelial connective tissue. Since Von Willebrand factor is not an enzyme it has no catalytic activity. vWF’s principal function is binding to other proteins, mainly to Factor VIII ａnd it is essential in platelet adhesion to wound sites. Factor VIII is attached to vWF while inactive in the circulation. Factor VIII degrades quickly when not attached to vWF. Description Factor VIII Related Antigen Human Recombinant （aa 2597-2791） expressed in E.coli, shows a 48 kDa band on SDS-PAGE.
The Factor-VIII RA is fused to GST-Tag ａnd purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation Factor VIII Related Antigen in 50mM Tris-Acetate, pH7.5, 1mM EDTA ａnd 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Factor VIII RA Human/重组人因子VIII相关抗原
产品编号：PRO-502
产品规格：2μg/5μg/10μg
Synonyms von Willebrand factor, vWF, F8VWF, VWD, Factor VIII Related Antigen, Factor-VIII RA. Introduction Factor VIII related antigen or von Willebrand factor is a multimeric glycoprotein. It has functional binding domains to platelet glycoprotein Ib, glycoprotein IIb/IIIa, collagen ａnd heparin. von Willebrand factor is synthesized by endothelial cells ａnd stored in the Weibel-Palade granules. It mediates platelet adhesion to injured vessel walls ａnd serves as a carrier ａnd stabilizer for coagulation factor VIII. von Willebrand factor is one of the most useful markers to identify endothelial （or megakaryocytic） lineage of neoplasms. As not all endothelial cells synthesize / store） this molecule, about 30% of tumors of vascular origin fail to stain for factor VIII related antigen, regardless of whether they are benign or malignant. Staining for factor VIII related antigen has also been used to measure angiogenesis, an indicator of tumor recurrence. vWF functions as both an antihemophilic factor carrier ａnd a platelet-vessel wall mediator in the blood coagulation system. vWF is critical to the hemostasis process. vWF is deficient or defective in von Willebrand disease ａnd is involved in a large number of other diseases, including thrombotic thrombocytopenic purpura, Heyde＇s syndrome, ａnd possibly hemolytic-uremic syndrome.
vWF is produced constitutively in the endothelium （in the Weibel-Palade bodies）, in the megakaryocytes （?-granules of platelets）, ａnd in the subendothelial connective tissue. Since Von Willebrand factor is not an enzyme it has no catalytic activity. vWF’s principal function is binding to other proteins, mainly to Factor VIII ａnd it is essential in platelet adhesion to wound sites. Factor VIII is attached to vWF while inactive in the circulation. Factor VIII degrades quickly when not attached to vWF. Description Factor VIII Related Antigen Human Recombinant （aa 2597-2791） expressed in E.coli, shows a 48 kDa band on SDS-PAGE.
The Factor-VIII RA is fused to GST-Tag ａnd purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation Factor VIII Related Antigen in 50mM Tris-Acetate, pH7.5, 1mM EDTA ａnd 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Factor VIII RA Human/重组人因子VIII相关抗原
产品编号：PRO-502
产品规格：2μg/5μg/10μg
Synonyms von Willebrand factor, vWF, F8VWF, VWD, Factor VIII Related Antigen, Factor-VIII RA. Introduction Factor VIII related antigen or von Willebrand factor is a multimeric glycoprotein. It has functional binding domains to platelet glycoprotein Ib, glycoprotein IIb/IIIa, collagen ａnd heparin. von Willebrand factor is synthesized by endothelial cells ａnd stored in the Weibel-Palade granules. It mediates platelet adhesion to injured vessel walls ａnd serves as a carrier ａnd stabilizer for coagulation factor VIII. von Willebrand factor is one of the most useful markers to identify endothelial （or megakaryocytic） lineage of neoplasms. As not all endothelial cells synthesize / store） this molecule, about 30% of tumors of vascular origin fail to stain for factor VIII related antigen, regardless of whether they are benign or malignant. Staining for factor VIII related antigen has also been used to measure angiogenesis, an indicator of tumor recurrence. vWF functions as both an antihemophilic factor carrier ａnd a platelet-vessel wall mediator in the blood coagulation system. vWF is critical to the hemostasis process. vWF is deficient or defective in von Willebrand disease ａnd is involved in a large number of other diseases, including thrombotic thrombocytopenic purpura, Heyde＇s syndrome, ａnd possibly hemolytic-uremic syndrome.
vWF is produced constitutively in the endothelium （in the Weibel-Palade bodies）, in the megakaryocytes （?-granules of platelets）, ａnd in the subendothelial connective tissue. Since Von Willebrand factor is not an enzyme it has no catalytic activity. vWF’s principal function is binding to other proteins, mainly to Factor VIII ａnd it is essential in platelet adhesion to wound sites. Factor VIII is attached to vWF while inactive in the circulation. Factor VIII degrades quickly when not attached to vWF. Description Factor VIII Related Antigen Human Recombinant （aa 2597-2791） expressed in E.coli, shows a 48 kDa band on SDS-PAGE.
The Factor-VIII RA is fused to GST-Tag ａnd purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation Factor VIII Related Antigen in 50mM Tris-Acetate, pH7.5, 1mM EDTA ａnd 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
产品规格：2μg/5μg/10μg
| Synonyms | von Willebrand factor, vWF, F8VWF, VWD, Factor VIII Related Antigen, Factor-VIII RA. |
| Introduction | Factor VIII related antigen or von Willebrand factor is a multimeric glycoprotein. It has functional binding domains to platelet glycoprotein Ib, glycoprotein IIb/IIIa, collagen ａnd heparin. von Willebrand factor is synthesized by endothelial cells ａnd stored in the Weibel-Palade granules. It mediates platelet adhesion to injured vessel walls ａnd serves as a carrier ａnd stabilizer for coagulation factor VIII. von Willebrand factor is one of the most useful markers to identify endothelial （or megakaryocytic） lineage of neoplasms. As not all endothelial cells synthesize / store） this molecule, about 30% of tumors of vascular origin fail to stain for factor VIII related antigen, regardless of whether they are benign or malignant. Staining for factor VIII related antigen has also been used to measure angiogenesis, an indicator of tumor recurrence. vWF functions as both an antihemophilic factor carrier ａnd a platelet-vessel wall mediator in the blood coagulation system. vWF is critical to the hemostasis process. vWF is deficient or defective in von Willebrand disease ａnd is involved in a large number of other diseases, including thrombotic thrombocytopenic purpura, Heyde＇s syndrome, ａnd possibly hemolytic-uremic syndrome. vWF is produced constitutively in the endothelium （in the Weibel-Palade bodies）, in the megakaryocytes （?-granules of platelets）, ａnd in the subendothelial connective tissue. Since Von Willebrand factor is not an enzyme it has no catalytic activity. vWF’s principal function is binding to other proteins, mainly to Factor VIII ａnd it is essential in platelet adhesion to wound sites. Factor VIII is attached to vWF while inactive in the circulation. Factor VIII degrades quickly when not attached to vWF. |
| Description | Factor VIII Related Antigen Human Recombinant （aa 2597-2791） expressed in E.coli, shows a 48 kDa band on SDS-PAGE. The Factor-VIII RA is fused to GST-Tag ａnd purified by proprietary chromatographic techniques. |
| Source | Escherichia Coli. |
| Physical Appearance | Sterile Filtered clear solution. |
| Formulation | Factor VIII Related Antigen in 50mM Tris-Acetate, pH7.5, 1mM EDTA ａnd 20% Glycerol. |
| Stability | Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months. Please prevent freeze-thaw cycles. |
| Usage | Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
