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ERa Human/重组人雌激素受体α
产品编号：PRO-499
产品规格：2μg/5μg/10μg
Synonyms Estrogen receptor, ER, Estradiol receptor, ER-alpha, Nuclear receptor subfamily 3 group A member 1, ESR1, ESR, NR3A1, Era, ESRA, DKFZp686N23123, ER-a, Estrogen Receptor alpha. Introduction Estrogen receptor is a ligand-activated transcription factor composed of several domains essential for hormone binding, DNA binding, ａnd activation of transcription. Estrogen ａnd its receptors are crucial for sexual development ａnd reproductive function, but also play a role in other tissues such as bone.
The Estrogen Receptor is a significant regulator of growth ａnd differentiation in the mammary gland. Estrogen receptors are also implicated in pathological processes including breast cancer, endometrial cancer, ａnd osteoporosis.
The presence of estrogen receptors in breast tumors indicates an increased probability of response to anti-estrogen therapy （e.g. tamoxifen）.
The Estrogen Receptor gene is divided into 8 exons having a genomic length of more than 140kbp.The Estrogen Receptor has 6 functionally separate domains, named A - F. alternative splicing results in a number of transcript variations, which differ in their 5＇ UTRs ａnd use different promoters. The protein is restricted to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Description ER ? Human Recombinant （a.a. 1-300） expressed in E.coli, shows a 59 kDa SDS-PAGE.
The ER ? is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation ER ? in 50mM Tris-Acetate, pH7.5, 1mM EDTA ａnd 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Applications ? ELISA
? Inhibition Assays
? Western Blotting. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
ERa Human/重组人雌激素受体α
产品编号：PRO-499
产品规格：2μg/5μg/10μg
Synonyms Estrogen receptor, ER, Estradiol receptor, ER-alpha, Nuclear receptor subfamily 3 group A member 1, ESR1, ESR, NR3A1, Era, ESRA, DKFZp686N23123, ER-a, Estrogen Receptor alpha. Introduction Estrogen receptor is a ligand-activated transcription factor composed of several domains essential for hormone binding, DNA binding, ａnd activation of transcription. Estrogen ａnd its receptors are crucial for sexual development ａnd reproductive function, but also play a role in other tissues such as bone.
The Estrogen Receptor is a significant regulator of growth ａnd differentiation in the mammary gland. Estrogen receptors are also implicated in pathological processes including breast cancer, endometrial cancer, ａnd osteoporosis.
The presence of estrogen receptors in breast tumors indicates an increased probability of response to anti-estrogen therapy （e.g. tamoxifen）.
The Estrogen Receptor gene is divided into 8 exons having a genomic length of more than 140kbp.The Estrogen Receptor has 6 functionally separate domains, named A - F. alternative splicing results in a number of transcript variations, which differ in their 5＇ UTRs ａnd use different promoters. The protein is restricted to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Description ER ? Human Recombinant （a.a. 1-300） expressed in E.coli, shows a 59 kDa SDS-PAGE.
The ER ? is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation ER ? in 50mM Tris-Acetate, pH7.5, 1mM EDTA ａnd 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Applications ? ELISA
? Inhibition Assays
? Western Blotting. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
ERa Human/重组人雌激素受体α
产品编号：PRO-499
产品规格：2μg/5μg/10μg
Synonyms Estrogen receptor, ER, Estradiol receptor, ER-alpha, Nuclear receptor subfamily 3 group A member 1, ESR1, ESR, NR3A1, Era, ESRA, DKFZp686N23123, ER-a, Estrogen Receptor alpha. Introduction Estrogen receptor is a ligand-activated transcription factor composed of several domains essential for hormone binding, DNA binding, ａnd activation of transcription. Estrogen ａnd its receptors are crucial for sexual development ａnd reproductive function, but also play a role in other tissues such as bone.
The Estrogen Receptor is a significant regulator of growth ａnd differentiation in the mammary gland. Estrogen receptors are also implicated in pathological processes including breast cancer, endometrial cancer, ａnd osteoporosis.
The presence of estrogen receptors in breast tumors indicates an increased probability of response to anti-estrogen therapy （e.g. tamoxifen）.
The Estrogen Receptor gene is divided into 8 exons having a genomic length of more than 140kbp.The Estrogen Receptor has 6 functionally separate domains, named A - F. alternative splicing results in a number of transcript variations, which differ in their 5＇ UTRs ａnd use different promoters. The protein is restricted to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Description ER ? Human Recombinant （a.a. 1-300） expressed in E.coli, shows a 59 kDa SDS-PAGE.
The ER ? is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation ER ? in 50mM Tris-Acetate, pH7.5, 1mM EDTA ａnd 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Applications ? ELISA
? Inhibition Assays
? Western Blotting. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
ERa Human/重组人雌激素受体α
产品编号：PRO-499
产品规格：2μg/5μg/10μg
Synonyms Estrogen receptor, ER, Estradiol receptor, ER-alpha, Nuclear receptor subfamily 3 group A member 1, ESR1, ESR, NR3A1, Era, ESRA, DKFZp686N23123, ER-a, Estrogen Receptor alpha. Introduction Estrogen receptor is a ligand-activated transcription factor composed of several domains essential for hormone binding, DNA binding, ａnd activation of transcription. Estrogen ａnd its receptors are crucial for sexual development ａnd reproductive function, but also play a role in other tissues such as bone.
The Estrogen Receptor is a significant regulator of growth ａnd differentiation in the mammary gland. Estrogen receptors are also implicated in pathological processes including breast cancer, endometrial cancer, ａnd osteoporosis.
The presence of estrogen receptors in breast tumors indicates an increased probability of response to anti-estrogen therapy （e.g. tamoxifen）.
The Estrogen Receptor gene is divided into 8 exons having a genomic length of more than 140kbp.The Estrogen Receptor has 6 functionally separate domains, named A - F. alternative splicing results in a number of transcript variations, which differ in their 5＇ UTRs ａnd use different promoters. The protein is restricted to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Description ER ? Human Recombinant （a.a. 1-300） expressed in E.coli, shows a 59 kDa SDS-PAGE.
The ER ? is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation ER ? in 50mM Tris-Acetate, pH7.5, 1mM EDTA ａnd 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Applications ? ELISA
? Inhibition Assays
? Western Blotting. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
ERa Human/重组人雌激素受体α
产品编号：PRO-499
产品规格：2μg/5μg/10μg
Synonyms Estrogen receptor, ER, Estradiol receptor, ER-alpha, Nuclear receptor subfamily 3 group A member 1, ESR1, ESR, NR3A1, Era, ESRA, DKFZp686N23123, ER-a, Estrogen Receptor alpha. Introduction Estrogen receptor is a ligand-activated transcription factor composed of several domains essential for hormone binding, DNA binding, ａnd activation of transcription. Estrogen ａnd its receptors are crucial for sexual development ａnd reproductive function, but also play a role in other tissues such as bone.
The Estrogen Receptor is a significant regulator of growth ａnd differentiation in the mammary gland. Estrogen receptors are also implicated in pathological processes including breast cancer, endometrial cancer, ａnd osteoporosis.
The presence of estrogen receptors in breast tumors indicates an increased probability of response to anti-estrogen therapy （e.g. tamoxifen）.
The Estrogen Receptor gene is divided into 8 exons having a genomic length of more than 140kbp.The Estrogen Receptor has 6 functionally separate domains, named A - F. alternative splicing results in a number of transcript variations, which differ in their 5＇ UTRs ａnd use different promoters. The protein is restricted to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Description ER ? Human Recombinant （a.a. 1-300） expressed in E.coli, shows a 59 kDa SDS-PAGE.
The ER ? is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation ER ? in 50mM Tris-Acetate, pH7.5, 1mM EDTA ａnd 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Applications ? ELISA
? Inhibition Assays
? Western Blotting. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
ERa Human/重组人雌激素受体α
产品编号：PRO-499
产品规格：2μg/5μg/10μg
Synonyms Estrogen receptor, ER, Estradiol receptor, ER-alpha, Nuclear receptor subfamily 3 group A member 1, ESR1, ESR, NR3A1, Era, ESRA, DKFZp686N23123, ER-a, Estrogen Receptor alpha. Introduction Estrogen receptor is a ligand-activated transcription factor composed of several domains essential for hormone binding, DNA binding, ａnd activation of transcription. Estrogen ａnd its receptors are crucial for sexual development ａnd reproductive function, but also play a role in other tissues such as bone.
The Estrogen Receptor is a significant regulator of growth ａnd differentiation in the mammary gland. Estrogen receptors are also implicated in pathological processes including breast cancer, endometrial cancer, ａnd osteoporosis.
The presence of estrogen receptors in breast tumors indicates an increased probability of response to anti-estrogen therapy （e.g. tamoxifen）.
The Estrogen Receptor gene is divided into 8 exons having a genomic length of more than 140kbp.The Estrogen Receptor has 6 functionally separate domains, named A - F. alternative splicing results in a number of transcript variations, which differ in their 5＇ UTRs ａnd use different promoters. The protein is restricted to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Description ER ? Human Recombinant （a.a. 1-300） expressed in E.coli, shows a 59 kDa SDS-PAGE.
The ER ? is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation ER ? in 50mM Tris-Acetate, pH7.5, 1mM EDTA ａnd 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Applications ? ELISA
? Inhibition Assays
? Western Blotting. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
ERa Human/重组人雌激素受体α
产品编号：PRO-499
产品规格：2μg/5μg/10μg
Synonyms Estrogen receptor, ER, Estradiol receptor, ER-alpha, Nuclear receptor subfamily 3 group A member 1, ESR1, ESR, NR3A1, Era, ESRA, DKFZp686N23123, ER-a, Estrogen Receptor alpha. Introduction Estrogen receptor is a ligand-activated transcription factor composed of several domains essential for hormone binding, DNA binding, ａnd activation of transcription. Estrogen ａnd its receptors are crucial for sexual development ａnd reproductive function, but also play a role in other tissues such as bone.
The Estrogen Receptor is a significant regulator of growth ａnd differentiation in the mammary gland. Estrogen receptors are also implicated in pathological processes including breast cancer, endometrial cancer, ａnd osteoporosis.
The presence of estrogen receptors in breast tumors indicates an increased probability of response to anti-estrogen therapy （e.g. tamoxifen）.
The Estrogen Receptor gene is divided into 8 exons having a genomic length of more than 140kbp.The Estrogen Receptor has 6 functionally separate domains, named A - F. alternative splicing results in a number of transcript variations, which differ in their 5＇ UTRs ａnd use different promoters. The protein is restricted to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Description ER ? Human Recombinant （a.a. 1-300） expressed in E.coli, shows a 59 kDa SDS-PAGE.
The ER ? is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation ER ? in 50mM Tris-Acetate, pH7.5, 1mM EDTA ａnd 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Applications ? ELISA
? Inhibition Assays
? Western Blotting. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
ERa Human/重组人雌激素受体α
产品编号：PRO-499
产品规格：2μg/5μg/10μg
Synonyms Estrogen receptor, ER, Estradiol receptor, ER-alpha, Nuclear receptor subfamily 3 group A member 1, ESR1, ESR, NR3A1, Era, ESRA, DKFZp686N23123, ER-a, Estrogen Receptor alpha. Introduction Estrogen receptor is a ligand-activated transcription factor composed of several domains essential for hormone binding, DNA binding, ａnd activation of transcription. Estrogen ａnd its receptors are crucial for sexual development ａnd reproductive function, but also play a role in other tissues such as bone.
The Estrogen Receptor is a significant regulator of growth ａnd differentiation in the mammary gland. Estrogen receptors are also implicated in pathological processes including breast cancer, endometrial cancer, ａnd osteoporosis.
The presence of estrogen receptors in breast tumors indicates an increased probability of response to anti-estrogen therapy （e.g. tamoxifen）.
The Estrogen Receptor gene is divided into 8 exons having a genomic length of more than 140kbp.The Estrogen Receptor has 6 functionally separate domains, named A - F. alternative splicing results in a number of transcript variations, which differ in their 5＇ UTRs ａnd use different promoters. The protein is restricted to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Description ER ? Human Recombinant （a.a. 1-300） expressed in E.coli, shows a 59 kDa SDS-PAGE.
The ER ? is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation ER ? in 50mM Tris-Acetate, pH7.5, 1mM EDTA ａnd 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Applications ? ELISA
? Inhibition Assays
? Western Blotting. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
ERa Human/重组人雌激素受体α
产品编号：PRO-499
产品规格：2μg/5μg/10μg
Synonyms Estrogen receptor, ER, Estradiol receptor, ER-alpha, Nuclear receptor subfamily 3 group A member 1, ESR1, ESR, NR3A1, Era, ESRA, DKFZp686N23123, ER-a, Estrogen Receptor alpha. Introduction Estrogen receptor is a ligand-activated transcription factor composed of several domains essential for hormone binding, DNA binding, ａnd activation of transcription. Estrogen ａnd its receptors are crucial for sexual development ａnd reproductive function, but also play a role in other tissues such as bone.
The Estrogen Receptor is a significant regulator of growth ａnd differentiation in the mammary gland. Estrogen receptors are also implicated in pathological processes including breast cancer, endometrial cancer, ａnd osteoporosis.
The presence of estrogen receptors in breast tumors indicates an increased probability of response to anti-estrogen therapy （e.g. tamoxifen）.
The Estrogen Receptor gene is divided into 8 exons having a genomic length of more than 140kbp.The Estrogen Receptor has 6 functionally separate domains, named A - F. alternative splicing results in a number of transcript variations, which differ in their 5＇ UTRs ａnd use different promoters. The protein is restricted to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Description ER ? Human Recombinant （a.a. 1-300） expressed in E.coli, shows a 59 kDa SDS-PAGE.
The ER ? is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation ER ? in 50mM Tris-Acetate, pH7.5, 1mM EDTA ａnd 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Applications ? ELISA
? Inhibition Assays
? Western Blotting. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
ERa Human/重组人雌激素受体α
产品编号：PRO-499
产品规格：2μg/5μg/10μg
Synonyms Estrogen receptor, ER, Estradiol receptor, ER-alpha, Nuclear receptor subfamily 3 group A member 1, ESR1, ESR, NR3A1, Era, ESRA, DKFZp686N23123, ER-a, Estrogen Receptor alpha. Introduction Estrogen receptor is a ligand-activated transcription factor composed of several domains essential for hormone binding, DNA binding, ａnd activation of transcription. Estrogen ａnd its receptors are crucial for sexual development ａnd reproductive function, but also play a role in other tissues such as bone.
The Estrogen Receptor is a significant regulator of growth ａnd differentiation in the mammary gland. Estrogen receptors are also implicated in pathological processes including breast cancer, endometrial cancer, ａnd osteoporosis.
The presence of estrogen receptors in breast tumors indicates an increased probability of response to anti-estrogen therapy （e.g. tamoxifen）.
The Estrogen Receptor gene is divided into 8 exons having a genomic length of more than 140kbp.The Estrogen Receptor has 6 functionally separate domains, named A - F. alternative splicing results in a number of transcript variations, which differ in their 5＇ UTRs ａnd use different promoters. The protein is restricted to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Description ER ? Human Recombinant （a.a. 1-300） expressed in E.coli, shows a 59 kDa SDS-PAGE.
The ER ? is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation ER ? in 50mM Tris-Acetate, pH7.5, 1mM EDTA ａnd 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Applications ? ELISA
? Inhibition Assays
? Western Blotting. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
ERa Human/重组人雌激素受体α
产品编号：PRO-499
产品规格：2μg/5μg/10μg
Synonyms Estrogen receptor, ER, Estradiol receptor, ER-alpha, Nuclear receptor subfamily 3 group A member 1, ESR1, ESR, NR3A1, Era, ESRA, DKFZp686N23123, ER-a, Estrogen Receptor alpha. Introduction Estrogen receptor is a ligand-activated transcription factor composed of several domains essential for hormone binding, DNA binding, ａnd activation of transcription. Estrogen ａnd its receptors are crucial for sexual development ａnd reproductive function, but also play a role in other tissues such as bone.
The Estrogen Receptor is a significant regulator of growth ａnd differentiation in the mammary gland. Estrogen receptors are also implicated in pathological processes including breast cancer, endometrial cancer, ａnd osteoporosis.
The presence of estrogen receptors in breast tumors indicates an increased probability of response to anti-estrogen therapy （e.g. tamoxifen）.
The Estrogen Receptor gene is divided into 8 exons having a genomic length of more than 140kbp.The Estrogen Receptor has 6 functionally separate domains, named A - F. alternative splicing results in a number of transcript variations, which differ in their 5＇ UTRs ａnd use different promoters. The protein is restricted to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Description ER ? Human Recombinant （a.a. 1-300） expressed in E.coli, shows a 59 kDa SDS-PAGE.
The ER ? is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation ER ? in 50mM Tris-Acetate, pH7.5, 1mM EDTA ａnd 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Applications ? ELISA
? Inhibition Assays
? Western Blotting. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
ERa Human/重组人雌激素受体α
产品编号：PRO-499
产品规格：2μg/5μg/10μg
Synonyms Estrogen receptor, ER, Estradiol receptor, ER-alpha, Nuclear receptor subfamily 3 group A member 1, ESR1, ESR, NR3A1, Era, ESRA, DKFZp686N23123, ER-a, Estrogen Receptor alpha. Introduction Estrogen receptor is a ligand-activated transcription factor composed of several domains essential for hormone binding, DNA binding, ａnd activation of transcription. Estrogen ａnd its receptors are crucial for sexual development ａnd reproductive function, but also play a role in other tissues such as bone.
The Estrogen Receptor is a significant regulator of growth ａnd differentiation in the mammary gland. Estrogen receptors are also implicated in pathological processes including breast cancer, endometrial cancer, ａnd osteoporosis.
The presence of estrogen receptors in breast tumors indicates an increased probability of response to anti-estrogen therapy （e.g. tamoxifen）.
The Estrogen Receptor gene is divided into 8 exons having a genomic length of more than 140kbp.The Estrogen Receptor has 6 functionally separate domains, named A - F. alternative splicing results in a number of transcript variations, which differ in their 5＇ UTRs ａnd use different promoters. The protein is restricted to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Description ER ? Human Recombinant （a.a. 1-300） expressed in E.coli, shows a 59 kDa SDS-PAGE.
The ER ? is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation ER ? in 50mM Tris-Acetate, pH7.5, 1mM EDTA ａnd 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Applications ? ELISA
? Inhibition Assays
? Western Blotting. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
ERa Human/重组人雌激素受体α
产品编号：PRO-499
产品规格：2μg/5μg/10μg
产品规格：2μg/5μg/10μg
| Synonyms | Estrogen receptor, ER, Estradiol receptor, ER-alpha, Nuclear receptor subfamily 3 group A member 1, ESR1, ESR, NR3A1, Era, ESRA, DKFZp686N23123, ER-a, Estrogen Receptor alpha. |
| Introduction | Estrogen receptor is a ligand-activated transcription factor composed of several domains essential for hormone binding, DNA binding, ａnd activation of transcription. Estrogen ａnd its receptors are crucial for sexual development ａnd reproductive function, but also play a role in other tissues such as bone. The Estrogen Receptor is a significant regulator of growth ａnd differentiation in the mammary gland. Estrogen receptors are also implicated in pathological processes including breast cancer, endometrial cancer, ａnd osteoporosis. The presence of estrogen receptors in breast tumors indicates an increased probability of response to anti-estrogen therapy （e.g. tamoxifen）. The Estrogen Receptor gene is divided into 8 exons having a genomic length of more than 140kbp.The Estrogen Receptor has 6 functionally separate domains, named A - F. alternative splicing results in a number of transcript variations, which differ in their 5＇ UTRs ａnd use different promoters. The protein is restricted to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. |
| Description | ER ? Human Recombinant （a.a. 1-300） expressed in E.coli, shows a 59 kDa SDS-PAGE. The ER ? is purified by proprietary chromatographic techniques. |
| Source | Escherichia Coli. |
| Physical Appearance | Sterile Filtered clear solution. |
| Formulation | ER ? in 50mM Tris-Acetate, pH7.5, 1mM EDTA ａnd 20% Glycerol. |
| Stability | Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months. Please prevent freeze-thaw cycles. |
| Applications | ? ELISA ? Inhibition Assays ? Western Blotting. |
| Usage | Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
