产品展示
PRO-248 Endostatin Human/重组人内皮抑素
点击次数：193发布时间：2012/10/23 17:26:52
更新日期：2024/10/16 16:00:31
所 在 地：美洲
产品型号：
优质供应
详细内容
慧嘉生物您实验身边的好伙伴
为客户提供“质量的产品”和“*优质的服务”
欢迎广大客户咨询，另有大量宣传海报和小礼品赠送。
联系电话：
传 真：
Q Q：
邮 箱：sale@biohj.com
Endostatin Human/重组人内皮抑素
产品编号：PRO-248
产品规格：20μg/100μg/1mg
Introduction Once a cluster of cancer cells reaches a diameter of about 1–2 mm, it must develop a blood supply in order to grow larger. Given that diffusion is no longer adequate to supply the cancerous cells with oxygen ａnd nutrients ａnd to remove wastes. Therefore, these cells secrete substances that promote the formation of new blood vessels （angiogenesis）, which are vital for the growth ａnd persistence of solid tumors ａnd their metastases.
The production of several angiogenic factors （FGF-a, FGF-b, VEGF ａnd VPF） is upregulated by tumors in order to stimulate angiogenesis. However, numerous malignant tumors also generate inhibitors of angiogenesis which include angiostatin ａnd thrombospondin. The angiogenic phenotype is basically the end result of a net balance between the positive ａnd negative regulators of neovascularization mentioned above. Endostatin’s role is to inhibit endothelial proliferation, therefore it is an effective angiogenesis inhibitor. Description Endostatin Human Recombinant produced in Pichia Pastoris is a single, glycosylated, polypeptide having a total molecular mass of 20,000 Dalton C-terminal fragment of collagen XVIII that has been shown to act as a potent inhibitor of angiogenesis ａnd tumor growth in vitro ａnd in vivo. Induces tyrosine phosphorylation of Shc （SH2 domain adapter protein） leading to specific inhibition in endothelial cell prolifiration.
The Endostatin is purified by proprietary chromatographic techniques. Source Pichia Pastoris. Physical Appearance Sterile filtered liquid formulation. Formulation The recombinant Human Endostatin is formulated with PBS. Stability Endostatin although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days.
Please avoid Freeze/Thaw cycles. Purity Greater than 98.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Amino Acid Composition In total agreement with the expected amino acid composition of native human Endostatin. Biological Activity The activity calculated by ECE migration inhibition was found to be 50,000IU/mg. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Endostatin Human/重组人内皮抑素
产品编号：PRO-248
产品规格：20μg/100μg/1mg
Introduction Once a cluster of cancer cells reaches a diameter of about 1–2 mm, it must develop a blood supply in order to grow larger. Given that diffusion is no longer adequate to supply the cancerous cells with oxygen ａnd nutrients ａnd to remove wastes. Therefore, these cells secrete substances that promote the formation of new blood vessels （angiogenesis）, which are vital for the growth ａnd persistence of solid tumors ａnd their metastases.
The production of several angiogenic factors （FGF-a, FGF-b, VEGF ａnd VPF） is upregulated by tumors in order to stimulate angiogenesis. However, numerous malignant tumors also generate inhibitors of angiogenesis which include angiostatin ａnd thrombospondin. The angiogenic phenotype is basically the end result of a net balance between the positive ａnd negative regulators of neovascularization mentioned above. Endostatin’s role is to inhibit endothelial proliferation, therefore it is an effective angiogenesis inhibitor. Description Endostatin Human Recombinant produced in Pichia Pastoris is a single, glycosylated, polypeptide having a total molecular mass of 20,000 Dalton C-terminal fragment of collagen XVIII that has been shown to act as a potent inhibitor of angiogenesis ａnd tumor growth in vitro ａnd in vivo. Induces tyrosine phosphorylation of Shc （SH2 domain adapter protein） leading to specific inhibition in endothelial cell prolifiration.
The Endostatin is purified by proprietary chromatographic techniques. Source Pichia Pastoris. Physical Appearance Sterile filtered liquid formulation. Formulation The recombinant Human Endostatin is formulated with PBS. Stability Endostatin although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days.
Please avoid Freeze/Thaw cycles. Purity Greater than 98.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Amino Acid Composition In total agreement with the expected amino acid composition of native human Endostatin. Biological Activity The activity calculated by ECE migration inhibition was found to be 50,000IU/mg. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Endostatin Human/重组人内皮抑素
产品编号：PRO-248
产品规格：20μg/100μg/1mg
Introduction Once a cluster of cancer cells reaches a diameter of about 1–2 mm, it must develop a blood supply in order to grow larger. Given that diffusion is no longer adequate to supply the cancerous cells with oxygen ａnd nutrients ａnd to remove wastes. Therefore, these cells secrete substances that promote the formation of new blood vessels （angiogenesis）, which are vital for the growth ａnd persistence of solid tumors ａnd their metastases.
The production of several angiogenic factors （FGF-a, FGF-b, VEGF ａnd VPF） is upregulated by tumors in order to stimulate angiogenesis. However, numerous malignant tumors also generate inhibitors of angiogenesis which include angiostatin ａnd thrombospondin. The angiogenic phenotype is basically the end result of a net balance between the positive ａnd negative regulators of neovascularization mentioned above. Endostatin’s role is to inhibit endothelial proliferation, therefore it is an effective angiogenesis inhibitor. Description Endostatin Human Recombinant produced in Pichia Pastoris is a single, glycosylated, polypeptide having a total molecular mass of 20,000 Dalton C-terminal fragment of collagen XVIII that has been shown to act as a potent inhibitor of angiogenesis ａnd tumor growth in vitro ａnd in vivo. Induces tyrosine phosphorylation of Shc （SH2 domain adapter protein） leading to specific inhibition in endothelial cell prolifiration.
The Endostatin is purified by proprietary chromatographic techniques. Source Pichia Pastoris. Physical Appearance Sterile filtered liquid formulation. Formulation The recombinant Human Endostatin is formulated with PBS. Stability Endostatin although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days.
Please avoid Freeze/Thaw cycles. Purity Greater than 98.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Amino Acid Composition In total agreement with the expected amino acid composition of native human Endostatin. Biological Activity The activity calculated by ECE migration inhibition was found to be 50,000IU/mg. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Endostatin Human/重组人内皮抑素
产品编号：PRO-248
产品规格：20μg/100μg/1mg
Introduction Once a cluster of cancer cells reaches a diameter of about 1–2 mm, it must develop a blood supply in order to grow larger. Given that diffusion is no longer adequate to supply the cancerous cells with oxygen ａnd nutrients ａnd to remove wastes. Therefore, these cells secrete substances that promote the formation of new blood vessels （angiogenesis）, which are vital for the growth ａnd persistence of solid tumors ａnd their metastases.
The production of several angiogenic factors （FGF-a, FGF-b, VEGF ａnd VPF） is upregulated by tumors in order to stimulate angiogenesis. However, numerous malignant tumors also generate inhibitors of angiogenesis which include angiostatin ａnd thrombospondin. The angiogenic phenotype is basically the end result of a net balance between the positive ａnd negative regulators of neovascularization mentioned above. Endostatin’s role is to inhibit endothelial proliferation, therefore it is an effective angiogenesis inhibitor. Description Endostatin Human Recombinant produced in Pichia Pastoris is a single, glycosylated, polypeptide having a total molecular mass of 20,000 Dalton C-terminal fragment of collagen XVIII that has been shown to act as a potent inhibitor of angiogenesis ａnd tumor growth in vitro ａnd in vivo. Induces tyrosine phosphorylation of Shc （SH2 domain adapter protein） leading to specific inhibition in endothelial cell prolifiration.
The Endostatin is purified by proprietary chromatographic techniques. Source Pichia Pastoris. Physical Appearance Sterile filtered liquid formulation. Formulation The recombinant Human Endostatin is formulated with PBS. Stability Endostatin although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days.
Please avoid Freeze/Thaw cycles. Purity Greater than 98.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Amino Acid Composition In total agreement with the expected amino acid composition of native human Endostatin. Biological Activity The activity calculated by ECE migration inhibition was found to be 50,000IU/mg. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Endostatin Human/重组人内皮抑素
产品编号：PRO-248
产品规格：20μg/100μg/1mg
Introduction Once a cluster of cancer cells reaches a diameter of about 1–2 mm, it must develop a blood supply in order to grow larger. Given that diffusion is no longer adequate to supply the cancerous cells with oxygen ａnd nutrients ａnd to remove wastes. Therefore, these cells secrete substances that promote the formation of new blood vessels （angiogenesis）, which are vital for the growth ａnd persistence of solid tumors ａnd their metastases.
The production of several angiogenic factors （FGF-a, FGF-b, VEGF ａnd VPF） is upregulated by tumors in order to stimulate angiogenesis. However, numerous malignant tumors also generate inhibitors of angiogenesis which include angiostatin ａnd thrombospondin. The angiogenic phenotype is basically the end result of a net balance between the positive ａnd negative regulators of neovascularization mentioned above. Endostatin’s role is to inhibit endothelial proliferation, therefore it is an effective angiogenesis inhibitor. Description Endostatin Human Recombinant produced in Pichia Pastoris is a single, glycosylated, polypeptide having a total molecular mass of 20,000 Dalton C-terminal fragment of collagen XVIII that has been shown to act as a potent inhibitor of angiogenesis ａnd tumor growth in vitro ａnd in vivo. Induces tyrosine phosphorylation of Shc （SH2 domain adapter protein） leading to specific inhibition in endothelial cell prolifiration.
The Endostatin is purified by proprietary chromatographic techniques. Source Pichia Pastoris. Physical Appearance Sterile filtered liquid formulation. Formulation The recombinant Human Endostatin is formulated with PBS. Stability Endostatin although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days.
Please avoid Freeze/Thaw cycles. Purity Greater than 98.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Amino Acid Composition In total agreement with the expected amino acid composition of native human Endostatin. Biological Activity The activity calculated by ECE migration inhibition was found to be 50,000IU/mg. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Endostatin Human/重组人内皮抑素
产品编号：PRO-248
产品规格：20μg/100μg/1mg
Introduction Once a cluster of cancer cells reaches a diameter of about 1–2 mm, it must develop a blood supply in order to grow larger. Given that diffusion is no longer adequate to supply the cancerous cells with oxygen ａnd nutrients ａnd to remove wastes. Therefore, these cells secrete substances that promote the formation of new blood vessels （angiogenesis）, which are vital for the growth ａnd persistence of solid tumors ａnd their metastases.
The production of several angiogenic factors （FGF-a, FGF-b, VEGF ａnd VPF） is upregulated by tumors in order to stimulate angiogenesis. However, numerous malignant tumors also generate inhibitors of angiogenesis which include angiostatin ａnd thrombospondin. The angiogenic phenotype is basically the end result of a net balance between the positive ａnd negative regulators of neovascularization mentioned above. Endostatin’s role is to inhibit endothelial proliferation, therefore it is an effective angiogenesis inhibitor. Description Endostatin Human Recombinant produced in Pichia Pastoris is a single, glycosylated, polypeptide having a total molecular mass of 20,000 Dalton C-terminal fragment of collagen XVIII that has been shown to act as a potent inhibitor of angiogenesis ａnd tumor growth in vitro ａnd in vivo. Induces tyrosine phosphorylation of Shc （SH2 domain adapter protein） leading to specific inhibition in endothelial cell prolifiration.
The Endostatin is purified by proprietary chromatographic techniques. Source Pichia Pastoris. Physical Appearance Sterile filtered liquid formulation. Formulation The recombinant Human Endostatin is formulated with PBS. Stability Endostatin although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days.
Please avoid Freeze/Thaw cycles. Purity Greater than 98.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Amino Acid Composition In total agreement with the expected amino acid composition of native human Endostatin. Biological Activity The activity calculated by ECE migration inhibition was found to be 50,000IU/mg. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Endostatin Human/重组人内皮抑素
产品编号：PRO-248
产品规格：20μg/100μg/1mg
Introduction Once a cluster of cancer cells reaches a diameter of about 1–2 mm, it must develop a blood supply in order to grow larger. Given that diffusion is no longer adequate to supply the cancerous cells with oxygen ａnd nutrients ａnd to remove wastes. Therefore, these cells secrete substances that promote the formation of new blood vessels （angiogenesis）, which are vital for the growth ａnd persistence of solid tumors ａnd their metastases.
The production of several angiogenic factors （FGF-a, FGF-b, VEGF ａnd VPF） is upregulated by tumors in order to stimulate angiogenesis. However, numerous malignant tumors also generate inhibitors of angiogenesis which include angiostatin ａnd thrombospondin. The angiogenic phenotype is basically the end result of a net balance between the positive ａnd negative regulators of neovascularization mentioned above. Endostatin’s role is to inhibit endothelial proliferation, therefore it is an effective angiogenesis inhibitor. Description Endostatin Human Recombinant produced in Pichia Pastoris is a single, glycosylated, polypeptide having a total molecular mass of 20,000 Dalton C-terminal fragment of collagen XVIII that has been shown to act as a potent inhibitor of angiogenesis ａnd tumor growth in vitro ａnd in vivo. Induces tyrosine phosphorylation of Shc （SH2 domain adapter protein） leading to specific inhibition in endothelial cell prolifiration.
The Endostatin is purified by proprietary chromatographic techniques. Source Pichia Pastoris. Physical Appearance Sterile filtered liquid formulation. Formulation The recombinant Human Endostatin is formulated with PBS. Stability Endostatin although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days.
Please avoid Freeze/Thaw cycles. Purity Greater than 98.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Amino Acid Composition In total agreement with the expected amino acid composition of native human Endostatin. Biological Activity The activity calculated by ECE migration inhibition was found to be 50,000IU/mg. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Endostatin Human/重组人内皮抑素
产品编号：PRO-248
产品规格：20μg/100μg/1mg
Introduction Once a cluster of cancer cells reaches a diameter of about 1–2 mm, it must develop a blood supply in order to grow larger. Given that diffusion is no longer adequate to supply the cancerous cells with oxygen ａnd nutrients ａnd to remove wastes. Therefore, these cells secrete substances that promote the formation of new blood vessels （angiogenesis）, which are vital for the growth ａnd persistence of solid tumors ａnd their metastases.
The production of several angiogenic factors （FGF-a, FGF-b, VEGF ａnd VPF） is upregulated by tumors in order to stimulate angiogenesis. However, numerous malignant tumors also generate inhibitors of angiogenesis which include angiostatin ａnd thrombospondin. The angiogenic phenotype is basically the end result of a net balance between the positive ａnd negative regulators of neovascularization mentioned above. Endostatin’s role is to inhibit endothelial proliferation, therefore it is an effective angiogenesis inhibitor. Description Endostatin Human Recombinant produced in Pichia Pastoris is a single, glycosylated, polypeptide having a total molecular mass of 20,000 Dalton C-terminal fragment of collagen XVIII that has been shown to act as a potent inhibitor of angiogenesis ａnd tumor growth in vitro ａnd in vivo. Induces tyrosine phosphorylation of Shc （SH2 domain adapter protein） leading to specific inhibition in endothelial cell prolifiration.
The Endostatin is purified by proprietary chromatographic techniques. Source Pichia Pastoris. Physical Appearance Sterile filtered liquid formulation. Formulation The recombinant Human Endostatin is formulated with PBS. Stability Endostatin although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days.
Please avoid Freeze/Thaw cycles. Purity Greater than 98.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Amino Acid Composition In total agreement with the expected amino acid composition of native human Endostatin. Biological Activity The activity calculated by ECE migration inhibition was found to be 50,000IU/mg. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Endostatin Human/重组人内皮抑素
产品编号：PRO-248
产品规格：20μg/100μg/1mg
Introduction Once a cluster of cancer cells reaches a diameter of about 1–2 mm, it must develop a blood supply in order to grow larger. Given that diffusion is no longer adequate to supply the cancerous cells with oxygen ａnd nutrients ａnd to remove wastes. Therefore, these cells secrete substances that promote the formation of new blood vessels （angiogenesis）, which are vital for the growth ａnd persistence of solid tumors ａnd their metastases.
The production of several angiogenic factors （FGF-a, FGF-b, VEGF ａnd VPF） is upregulated by tumors in order to stimulate angiogenesis. However, numerous malignant tumors also generate inhibitors of angiogenesis which include angiostatin ａnd thrombospondin. The angiogenic phenotype is basically the end result of a net balance between the positive ａnd negative regulators of neovascularization mentioned above. Endostatin’s role is to inhibit endothelial proliferation, therefore it is an effective angiogenesis inhibitor. Description Endostatin Human Recombinant produced in Pichia Pastoris is a single, glycosylated, polypeptide having a total molecular mass of 20,000 Dalton C-terminal fragment of collagen XVIII that has been shown to act as a potent inhibitor of angiogenesis ａnd tumor growth in vitro ａnd in vivo. Induces tyrosine phosphorylation of Shc （SH2 domain adapter protein） leading to specific inhibition in endothelial cell prolifiration.
The Endostatin is purified by proprietary chromatographic techniques. Source Pichia Pastoris. Physical Appearance Sterile filtered liquid formulation. Formulation The recombinant Human Endostatin is formulated with PBS. Stability Endostatin although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days.
Please avoid Freeze/Thaw cycles. Purity Greater than 98.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Amino Acid Composition In total agreement with the expected amino acid composition of native human Endostatin. Biological Activity The activity calculated by ECE migration inhibition was found to be 50,000IU/mg. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Endostatin Human/重组人内皮抑素
产品编号：PRO-248
产品规格：20μg/100μg/1mg
Introduction Once a cluster of cancer cells reaches a diameter of about 1–2 mm, it must develop a blood supply in order to grow larger. Given that diffusion is no longer adequate to supply the cancerous cells with oxygen ａnd nutrients ａnd to remove wastes. Therefore, these cells secrete substances that promote the formation of new blood vessels （angiogenesis）, which are vital for the growth ａnd persistence of solid tumors ａnd their metastases.
The production of several angiogenic factors （FGF-a, FGF-b, VEGF ａnd VPF） is upregulated by tumors in order to stimulate angiogenesis. However, numerous malignant tumors also generate inhibitors of angiogenesis which include angiostatin ａnd thrombospondin. The angiogenic phenotype is basically the end result of a net balance between the positive ａnd negative regulators of neovascularization mentioned above. Endostatin’s role is to inhibit endothelial proliferation, therefore it is an effective angiogenesis inhibitor. Description Endostatin Human Recombinant produced in Pichia Pastoris is a single, glycosylated, polypeptide having a total molecular mass of 20,000 Dalton C-terminal fragment of collagen XVIII that has been shown to act as a potent inhibitor of angiogenesis ａnd tumor growth in vitro ａnd in vivo. Induces tyrosine phosphorylation of Shc （SH2 domain adapter protein） leading to specific inhibition in endothelial cell prolifiration.
The Endostatin is purified by proprietary chromatographic techniques. Source Pichia Pastoris. Physical Appearance Sterile filtered liquid formulation. Formulation The recombinant Human Endostatin is formulated with PBS. Stability Endostatin although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days.
Please avoid Freeze/Thaw cycles. Purity Greater than 98.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Amino Acid Composition In total agreement with the expected amino acid composition of native human Endostatin. Biological Activity The activity calculated by ECE migration inhibition was found to be 50,000IU/mg. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Endostatin Human/重组人内皮抑素
产品编号：PRO-248
产品规格：20μg/100μg/1mg
Introduction Once a cluster of cancer cells reaches a diameter of about 1–2 mm, it must develop a blood supply in order to grow larger. Given that diffusion is no longer adequate to supply the cancerous cells with oxygen ａnd nutrients ａnd to remove wastes. Therefore, these cells secrete substances that promote the formation of new blood vessels （angiogenesis）, which are vital for the growth ａnd persistence of solid tumors ａnd their metastases.
The production of several angiogenic factors （FGF-a, FGF-b, VEGF ａnd VPF） is upregulated by tumors in order to stimulate angiogenesis. However, numerous malignant tumors also generate inhibitors of angiogenesis which include angiostatin ａnd thrombospondin. The angiogenic phenotype is basically the end result of a net balance between the positive ａnd negative regulators of neovascularization mentioned above. Endostatin’s role is to inhibit endothelial proliferation, therefore it is an effective angiogenesis inhibitor. Description Endostatin Human Recombinant produced in Pichia Pastoris is a single, glycosylated, polypeptide having a total molecular mass of 20,000 Dalton C-terminal fragment of collagen XVIII that has been shown to act as a potent inhibitor of angiogenesis ａnd tumor growth in vitro ａnd in vivo. Induces tyrosine phosphorylation of Shc （SH2 domain adapter protein） leading to specific inhibition in endothelial cell prolifiration.
The Endostatin is purified by proprietary chromatographic techniques. Source Pichia Pastoris. Physical Appearance Sterile filtered liquid formulation. Formulation The recombinant Human Endostatin is formulated with PBS. Stability Endostatin although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days.
Please avoid Freeze/Thaw cycles. Purity Greater than 98.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Amino Acid Composition In total agreement with the expected amino acid composition of native human Endostatin. Biological Activity The activity calculated by ECE migration inhibition was found to be 50,000IU/mg. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Endostatin Human/重组人内皮抑素
产品编号：PRO-248
产品规格：20μg/100μg/1mg
Introduction Once a cluster of cancer cells reaches a diameter of about 1–2 mm, it must develop a blood supply in order to grow larger. Given that diffusion is no longer adequate to supply the cancerous cells with oxygen ａnd nutrients ａnd to remove wastes. Therefore, these cells secrete substances that promote the formation of new blood vessels （angiogenesis）, which are vital for the growth ａnd persistence of solid tumors ａnd their metastases.
The production of several angiogenic factors （FGF-a, FGF-b, VEGF ａnd VPF） is upregulated by tumors in order to stimulate angiogenesis. However, numerous malignant tumors also generate inhibitors of angiogenesis which include angiostatin ａnd thrombospondin. The angiogenic phenotype is basically the end result of a net balance between the positive ａnd negative regulators of neovascularization mentioned above. Endostatin’s role is to inhibit endothelial proliferation, therefore it is an effective angiogenesis inhibitor. Description Endostatin Human Recombinant produced in Pichia Pastoris is a single, glycosylated, polypeptide having a total molecular mass of 20,000 Dalton C-terminal fragment of collagen XVIII that has been shown to act as a potent inhibitor of angiogenesis ａnd tumor growth in vitro ａnd in vivo. Induces tyrosine phosphorylation of Shc （SH2 domain adapter protein） leading to specific inhibition in endothelial cell prolifiration.
The Endostatin is purified by proprietary chromatographic techniques. Source Pichia Pastoris. Physical Appearance Sterile filtered liquid formulation. Formulation The recombinant Human Endostatin is formulated with PBS. Stability Endostatin although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days.
Please avoid Freeze/Thaw cycles. Purity Greater than 98.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Amino Acid Composition In total agreement with the expected amino acid composition of native human Endostatin. Biological Activity The activity calculated by ECE migration inhibition was found to be 50,000IU/mg. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Endostatin Human/重组人内皮抑素
产品编号：PRO-248
产品规格：20μg/100μg/1mg
Introduction Once a cluster of cancer cells reaches a diameter of about 1–2 mm, it must develop a blood supply in order to grow larger. Given that diffusion is no longer adequate to supply the cancerous cells with oxygen ａnd nutrients ａnd to remove wastes. Therefore, these cells secrete substances that promote the formation of new blood vessels （angiogenesis）, which are vital for the growth ａnd persistence of solid tumors ａnd their metastases.
The production of several angiogenic factors （FGF-a, FGF-b, VEGF ａnd VPF） is upregulated by tumors in order to stimulate angiogenesis. However, numerous malignant tumors also generate inhibitors of angiogenesis which include angiostatin ａnd thrombospondin. The angiogenic phenotype is basically the end result of a net balance between the positive ａnd negative regulators of neovascularization mentioned above. Endostatin’s role is to inhibit endothelial proliferation, therefore it is an effective angiogenesis inhibitor. Description Endostatin Human Recombinant produced in Pichia Pastoris is a single, glycosylated, polypeptide having a total molecular mass of 20,000 Dalton C-terminal fragment of collagen XVIII that has been shown to act as a potent inhibitor of angiogenesis ａnd tumor growth in vitro ａnd in vivo. Induces tyrosine phosphorylation of Shc （SH2 domain adapter protein） leading to specific inhibition in endothelial cell prolifiration.
The Endostatin is purified by proprietary chromatographic techniques. Source Pichia Pastoris. Physical Appearance Sterile filtered liquid formulation. Formulation The recombinant Human Endostatin is formulated with PBS. Stability Endostatin although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days.
Please avoid Freeze/Thaw cycles. Purity Greater than 98.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Amino Acid Composition In total agreement with the expected amino acid composition of native human Endostatin. Biological Activity The activity calculated by ECE migration inhibition was found to be 50,000IU/mg. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Endostatin Human/重组人内皮抑素
产品编号：PRO-248
产品规格：20μg/100μg/1mg
Introduction Once a cluster of cancer cells reaches a diameter of about 1–2 mm, it must develop a blood supply in order to grow larger. Given that diffusion is no longer adequate to supply the cancerous cells with oxygen ａnd nutrients ａnd to remove wastes. Therefore, these cells secrete substances that promote the formation of new blood vessels （angiogenesis）, which are vital for the growth ａnd persistence of solid tumors ａnd their metastases.
The production of several angiogenic factors （FGF-a, FGF-b, VEGF ａnd VPF） is upregulated by tumors in order to stimulate angiogenesis. However, numerous malignant tumors also generate inhibitors of angiogenesis which include angiostatin ａnd thrombospondin. The angiogenic phenotype is basically the end result of a net balance between the positive ａnd negative regulators of neovascularization mentioned above. Endostatin’s role is to inhibit endothelial proliferation, therefore it is an effective angiogenesis inhibitor. Description Endostatin Human Recombinant produced in Pichia Pastoris is a single, glycosylated, polypeptide having a total molecular mass of 20,000 Dalton C-terminal fragment of collagen XVIII that has been shown to act as a potent inhibitor of angiogenesis ａnd tumor growth in vitro ａnd in vivo. Induces tyrosine phosphorylation of Shc （SH2 domain adapter protein） leading to specific inhibition in endothelial cell prolifiration.
The Endostatin is purified by proprietary chromatographic techniques. Source Pichia Pastoris. Physical Appearance Sterile filtered liquid formulation. Formulation The recombinant Human Endostatin is formulated with PBS. Stability Endostatin although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days.
Please avoid Freeze/Thaw cycles. Purity Greater than 98.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Amino Acid Composition In total agreement with the expected amino acid composition of native human Endostatin. Biological Activity The activity calculated by ECE migration inhibition was found to be 50,000IU/mg. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Endostatin Human/重组人内皮抑素
产品编号：PRO-248
产品规格：20μg/100μg/1mg
Introduction Once a cluster of cancer cells reaches a diameter of about 1–2 mm, it must develop a blood supply in order to grow larger. Given that diffusion is no longer adequate to supply the cancerous cells with oxygen ａnd nutrients ａnd to remove wastes. Therefore, these cells secrete substances that promote the formation of new blood vessels （angiogenesis）, which are vital for the growth ａnd persistence of solid tumors ａnd their metastases.
The production of several angiogenic factors （FGF-a, FGF-b, VEGF ａnd VPF） is upregulated by tumors in order to stimulate angiogenesis. However, numerous malignant tumors also generate inhibitors of angiogenesis which include angiostatin ａnd thrombospondin. The angiogenic phenotype is basically the end result of a net balance between the positive ａnd negative regulators of neovascularization mentioned above. Endostatin’s role is to inhibit endothelial proliferation, therefore it is an effective angiogenesis inhibitor. Description Endostatin Human Recombinant produced in Pichia Pastoris is a single, glycosylated, polypeptide having a total molecular mass of 20,000 Dalton C-terminal fragment of collagen XVIII that has been shown to act as a potent inhibitor of angiogenesis ａnd tumor growth in vitro ａnd in vivo. Induces tyrosine phosphorylation of Shc （SH2 domain adapter protein） leading to specific inhibition in endothelial cell prolifiration.
The Endostatin is purified by proprietary chromatographic techniques. Source Pichia Pastoris. Physical Appearance Sterile filtered liquid formulation. Formulation The recombinant Human Endostatin is formulated with PBS. Stability Endostatin although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days.
Please avoid Freeze/Thaw cycles. Purity Greater than 98.0% as determined by（a） Analysis by RP-HPLC.
（b） Analysis by SDS-PAGE. Amino Acid Composition In total agreement with the expected amino acid composition of native human Endostatin. Biological Activity The activity calculated by ECE migration inhibition was found to be 50,000IU/mg. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
产品规格：20μg/100μg/1mg
| Introduction | Once a cluster of cancer cells reaches a diameter of about 1–2 mm, it must develop a blood supply in order to grow larger. Given that diffusion is no longer adequate to supply the cancerous cells with oxygen ａnd nutrients ａnd to remove wastes. Therefore, these cells secrete substances that promote the formation of new blood vessels （angiogenesis）, which are vital for the growth ａnd persistence of solid tumors ａnd their metastases. The production of several angiogenic factors （FGF-a, FGF-b, VEGF ａnd VPF） is upregulated by tumors in order to stimulate angiogenesis. However, numerous malignant tumors also generate inhibitors of angiogenesis which include angiostatin ａnd thrombospondin. The angiogenic phenotype is basically the end result of a net balance between the positive ａnd negative regulators of neovascularization mentioned above. Endostatin’s role is to inhibit endothelial proliferation, therefore it is an effective angiogenesis inhibitor. |
| Description | Endostatin Human Recombinant produced in Pichia Pastoris is a single, glycosylated, polypeptide having a total molecular mass of 20,000 Dalton C-terminal fragment of collagen XVIII that has been shown to act as a potent inhibitor of angiogenesis ａnd tumor growth in vitro ａnd in vivo. Induces tyrosine phosphorylation of Shc （SH2 domain adapter protein） leading to specific inhibition in endothelial cell prolifiration. The Endostatin is purified by proprietary chromatographic techniques. |
| Source | Pichia Pastoris. |
| Physical Appearance | Sterile filtered liquid formulation. |
| Formulation | The recombinant Human Endostatin is formulated with PBS. |
| Stability | Endostatin although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days. Please avoid Freeze/Thaw cycles. |
| Purity | Greater than 98.0% as determined by（a） Analysis by RP-HPLC. （b） Analysis by SDS-PAGE. |
| Amino Acid Composition | In total agreement with the expected amino acid composition of native human Endostatin. |
| Biological Activity | The activity calculated by ECE migration inhibition was found to be 50,000IU/mg. |
| Usage | Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
