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CRABP1 Human/重组人细胞视黄酸结合蛋白1
点击次数：118发布时间：2012/10/27 10:37:46
更新日期：2024/10/16 16:00:43
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CRABP1 Human/重组人细胞视黄酸结合蛋白1
产品编号：PRO-710
产品规格：5μg/20μg/1mg
慧嘉生物您实验身边的好伙伴
CRABP1 Human/重组人细胞视黄酸结合蛋白1
产品编号：PRO-710
产品规格：5μg/20μg/1mg
慧嘉生物您实验身边的好伙伴
CRABP1 Human/重组人细胞视黄酸结合蛋白1
产品编号：PRO-710
产品规格：5μg/20μg/1mg
慧嘉生物您实验身边的好伙伴
CRABP1 Human/重组人细胞视黄酸结合蛋白1
产品编号：PRO-710
产品规格：5μg/20μg/1mg
慧嘉生物您实验身边的好伙伴
CRABP1 Human/重组人细胞视黄酸结合蛋白1
产品编号：PRO-710
产品规格：5μg/20μg/1mg
CRABP1 Human/重组人细胞视黄酸结合蛋白1
产品编号：PRO-710
产品规格：5μg/20μg/1mg
CRABP1 Human/重组人细胞视黄酸结合蛋白1
产品编号：PRO-710
产品规格：5μg/20μg/1mg
CRABP1 Human/重组人细胞视黄酸结合蛋白1
产品编号：PRO-710
产品规格：5μg/20μg/1mg
产品规格：5μg/20μg/1mg
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| Synonyms | Cellular retinoic acid-binding protein 1, Cellular retinoic acid-binding protein I, CRABP-I, CRABP1, RBP5, CRABP, CRABPI. |
| Introduction | CRABP1 is a member of special carrier proteins for members of the vitamin A family. It is believed that CRABP1 has an essential role in retinoic acid-mediated differentiation ａnd proliferation processes. Though, CRABP1 is structurally similar to the cellular retinol-binding proteins, it binds only retinoic acid at specific sites within the nucleus, which may contribute to vitamin A-directed differentiation in epithelial tissue. CRABP1 is constitutively expressed ａnd is thought to have different functions in the cell than the related CRABP2. CRABP1 forms a beta-barrel structure which accommodates hydrophobic ligands in its interior. Loss of CRABP1 function as a result of hypermethylation of its promoter leads to pathogenesis of papillary thyroid carcinoma. Furthermore, frequent methylation-associated silencing of CRABP1 is linked to esophageal squamous-cell carcinoma. |
| Description | CRABP1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 137 amino acids ａnd having a molecular mass of 15.5kDa. The CRABP1 is purified by proprietary chromatographic techniques. |
| Source | Escherichia Coli. |
| Physical Appearance | Sterile Filtered colorless solution. |
| Formulation | The CRABP1 protein solution contains 20mM Tris-HCl buffer （pH8.0） ａnd 10% glycerol. |
| Stability | CRABP1 although stable 4°C for 4 weeks, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles. |
| Amino Acid Sequence | MPNFAGTWKM RSSENFDELL KALGVNAMLR KVAVAAASKP HVEIRQDGDQ FYIKTSTTVR TTEINFKVGE GFEEETVDGR KCRSLATWEN ENKIHCTQTL LEGDGPKTYW TRELANDELI LTFGADDVVC TRIYVRE. |
| Purity | Greater than 95.0% as determined by（a） Analysis by RP-HPLC. （b） Analysis by SDS-PAGE. |
| Usage | ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
