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ATXN3 Human/重组人Ataxin3
点击次数：200发布时间：2012/10/27 11:12:08
更新日期：2024/10/16 16:00:43
所 在 地：美洲
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ATXN3 Human/重组人Ataxin3
产品编号：PRO-708
产品规格：2μg/10μg/1mg
慧嘉生物您实验身边的好伙伴
ATXN3 Human/重组人Ataxin3
产品编号：PRO-708
产品规格：2μg/10μg/1mg
慧嘉生物您实验身边的好伙伴
ATXN3 Human/重组人Ataxin3
产品编号：PRO-708
产品规格：2μg/10μg/1mg
慧嘉生物您实验身边的好伙伴
ATXN3 Human/重组人Ataxin3
产品编号：PRO-708
产品规格：2μg/10μg/1mg
慧嘉生物您实验身边的好伙伴
ATXN3 Human/重组人Ataxin3
产品编号：PRO-708
产品规格：2μg/10μg/1mg
慧嘉生物您实验身边的好伙伴
ATXN3 Human/重组人Ataxin3
产品编号：PRO-708
产品规格：2μg/10μg/1mg
慧嘉生物您实验身边的好伙伴
ATXN3 Human/重组人Ataxin3
产品编号：PRO-708
产品规格：2μg/10μg/1mg
慧嘉生物您实验身边的好伙伴
ATXN3 Human/重组人Ataxin3
产品编号：PRO-708
产品规格：2μg/10μg/1mg
慧嘉生物您实验身边的好伙伴
ATXN3 Human/重组人Ataxin3
产品编号：PRO-708
产品规格：2μg/10μg/1mg
慧嘉生物您实验身边的好伙伴
ATXN3 Human/重组人Ataxin3
产品编号：PRO-708
产品规格：2μg/10μg/1mg
慧嘉生物您实验身边的好伙伴
ATXN3 Human/重组人Ataxin3
产品编号：PRO-708
产品规格：2μg/10μg/1mg
慧嘉生物您实验身边的好伙伴
ATXN3 Human/重组人Ataxin3
产品编号：PRO-708
产品规格：2μg/10μg/1mg
慧嘉生物您实验身边的好伙伴
ATXN3 Human/重组人Ataxin3
产品编号：PRO-708
产品规格：2μg/10μg/1mg
慧嘉生物您实验身边的好伙伴
ATXN3 Human/重组人Ataxin3
产品编号：PRO-708
产品规格：2μg/10μg/1mg
慧嘉生物您实验身边的好伙伴
ATXN3 Human/重组人Ataxin3
产品编号：PRO-708
产品规格：2μg/10μg/1mg
慧嘉生物您实验身边的好伙伴
ATXN3 Human/重组人Ataxin3
产品编号：PRO-708
产品规格：2μg/10μg/1mg
慧嘉生物您实验身边的好伙伴
ATXN3 Human/重组人Ataxin3
产品编号：PRO-708
产品规格：2μg/10μg/1mg
慧嘉生物您实验身边的好伙伴
ATXN3 Human/重组人Ataxin3
产品编号：PRO-708
产品规格：2μg/10μg/1mg
慧嘉生物您实验身边的好伙伴
ATXN3 Human/重组人Ataxin3
产品编号：PRO-708
产品规格：2μg/10μg/1mg
慧嘉生物您实验身边的好伙伴
ATXN3 Human/重组人Ataxin3
产品编号：PRO-708
产品规格：2μg/10μg/1mg
慧嘉生物您实验身边的好伙伴
ATXN3 Human/重组人Ataxin3
产品编号：PRO-708
产品规格：2μg/10μg/1mg
ATXN3 Human/重组人Ataxin3
产品编号：PRO-708
产品规格：2μg/10μg/1mg
ATXN3 Human/重组人Ataxin3
产品编号：PRO-708
产品规格：2μg/10μg/1mg
产品规格：2μg/10μg/1mg
慧嘉生物您实验身边的好伙伴
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| Synonyms | Ataxin-3, Machado-Joseph disease protein 1, Spinocerebellar ataxia type 3 protein, ATXN3, ATX3, MJD, MJD1, SCA3, AT3, JOS. |
| Introduction | Ataxin 3 is otherwise known as Machado-Joseph disease protein 1. Machado–Joseph disease is a hereditary autosomal dominant neurodegenerative disorder. ATXN3 contains trinucleotide CAG repeats in the coding region, ａnd the expansion of these repeats from the normal 13-36 to 68-79 causes the Machado-Joseph disease. ATXN3 is a poly-ubiquitin-binding protein whose cellular turnover is regulated by its catalytic activity. In addition, ATXN3 is a proteasome-associated factor which mediates the degradation of ubiquitinated proteins. ATXN3 folds reversibly using a single intermediate; partial destabilization of ATXN3 by chemical denaturation causes the formation of fibrillar aggregates by the non-pathological variant. Ataxin-3 interacts with the major histone acetyltransferases cAMP-response-element binding protein （CREB）-binding protein, p300, ａnd p300/CREB-binding protein-associated factor ａnd hinders transcription by these coactivators. |
| Description | ATXN3 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 370 amino acids （1-370 a.a.） ａnd having a molecular mass of 42.4kDa. ATXN3 is purified by proprietary chromatographic techniques. |
| Source | Escherichia Coli. |
| Physical Appearance | Sterile filtered colorless solution. |
| Formulation | The ATXN3 protein solution contains 20mM Tris-HCl buffer （pH 7.5）, 2mM DTT, 50mM NaCl ａnd 10% glycerol. |
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Avoid multiple freeze-thaw cycles. |
| Purity | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence | MESIFHEKQE GSLCAQHCLN NLLQGEYFSP VELSSIAHQL DEEERMRMAE GGVTSEDYRT FLQQPSGNMD DSGFFSIQVI SNALKVWGLELILFNSPEYQ RLRIDPINER SFICNYKEHW FTVRKLGKQW FNLNSLLTGP ELISDTYLAL FLAQLQQEGY SIFVVKGDLP DCEADQLLQM IRVQQMHRPK LIGEELAQLK EQRVHKTDLE RVLEANDGSG MLDEDEEDLQ RALALSRQEI DMEDEEADLR RAIQLSMQGS SRNISQDMTQ TSGTNLTSEE LRKRREAYFE KQQQKQQQQQ QQQQQQQQQQ QQQQGDLSGQ SSHPCERPAT SSGALGSDLG DAMSEEDMLQ AAVTMSLETV RNDLKTEGKK. |
| Usage | ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
