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PGP9.5 Human/ 重组人泛素羧基末端水解酶同工酶L1
点击次数：192发布时间：2012/10/28 19:40:09
更新日期：2024/10/16 16:00:43
所 在 地：美洲
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PGP9.5 Human/ 重组人泛素羧基末端水解酶同工酶L1
产品编号：PRO-576
产品规格：5μg/25μg/1mg
Synonyms Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1, EC 3.4.19.12, Ubiquitin thioesterase L1, Neuron cytoplasmic protein 9.5, PGP 9.5, UCHL1, PGP9.5, PARK5. Introduction UCHL1 （PGP9.5） belongs to a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to produce the ubiquitin monomer. Protein Gene Product （PGP9.5） is a neuron specific protein, structurally ａnd immunologically distinct from neuron specific enolase. Human UCHL1 ａnd UCHL3 have an extremely complicated knot structure for a protein, with five knot crossings. It is considered that the knot structure may increase a protein＇s resistance to degradation in the proteasome.
The protein, which has a molecular weight of 27 kDa was first defined by high resolution two dimetional PAGE. Standard immunohistochemical techniques have demonstrated the presence of PGP9.5 in neurons ａnd nerve fibers at all levels of the central ａnd peripheral nervous system, in many neurodcrine cells, in segments of the renal tubules, in spermatogonia ａnd leydig cells of the testis, in ova ａnd in some cells of both the pregnant ａnd non pregnant corpus luteum. A point mutation （I93M） in UCHL1 is implicated as the cause of Parkinson＇s disease in one kindred. On the other hand, a polymorphism （S18Y） in UCHL1 has been found to be associated with a reduced risk for Parkinson＇s disease. Furthermore, UCHL1 is associated with the Alzheimer＇s disease, ａnd required for normal synaptic ａnd cognitive function. Description PGP9.5 Human Recombinant full length protein expressed in E.coli, shows a 36 kDa band on SDS-PAGE.
The PGP9.5 is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation PGP9.5 in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Applications ? ELISA
? Inhibition Assays
? Western Blotting. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
慧嘉生物您实验身边的好伙伴
PGP9.5 Human/ 重组人泛素羧基末端水解酶同工酶L1
产品编号：PRO-576
产品规格：5μg/25μg/1mg
Synonyms Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1, EC 3.4.19.12, Ubiquitin thioesterase L1, Neuron cytoplasmic protein 9.5, PGP 9.5, UCHL1, PGP9.5, PARK5. Introduction UCHL1 （PGP9.5） belongs to a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to produce the ubiquitin monomer. Protein Gene Product （PGP9.5） is a neuron specific protein, structurally ａnd immunologically distinct from neuron specific enolase. Human UCHL1 ａnd UCHL3 have an extremely complicated knot structure for a protein, with five knot crossings. It is considered that the knot structure may increase a protein＇s resistance to degradation in the proteasome.
The protein, which has a molecular weight of 27 kDa was first defined by high resolution two dimetional PAGE. Standard immunohistochemical techniques have demonstrated the presence of PGP9.5 in neurons ａnd nerve fibers at all levels of the central ａnd peripheral nervous system, in many neurodcrine cells, in segments of the renal tubules, in spermatogonia ａnd leydig cells of the testis, in ova ａnd in some cells of both the pregnant ａnd non pregnant corpus luteum. A point mutation （I93M） in UCHL1 is implicated as the cause of Parkinson＇s disease in one kindred. On the other hand, a polymorphism （S18Y） in UCHL1 has been found to be associated with a reduced risk for Parkinson＇s disease. Furthermore, UCHL1 is associated with the Alzheimer＇s disease, ａnd required for normal synaptic ａnd cognitive function. Description PGP9.5 Human Recombinant full length protein expressed in E.coli, shows a 36 kDa band on SDS-PAGE.
The PGP9.5 is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation PGP9.5 in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Applications ? ELISA
? Inhibition Assays
? Western Blotting. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
慧嘉生物您实验身边的好伙伴
PGP9.5 Human/ 重组人泛素羧基末端水解酶同工酶L1
产品编号：PRO-576
产品规格：5μg/25μg/1mg
Synonyms Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1, EC 3.4.19.12, Ubiquitin thioesterase L1, Neuron cytoplasmic protein 9.5, PGP 9.5, UCHL1, PGP9.5, PARK5. Introduction UCHL1 （PGP9.5） belongs to a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to produce the ubiquitin monomer. Protein Gene Product （PGP9.5） is a neuron specific protein, structurally ａnd immunologically distinct from neuron specific enolase. Human UCHL1 ａnd UCHL3 have an extremely complicated knot structure for a protein, with five knot crossings. It is considered that the knot structure may increase a protein＇s resistance to degradation in the proteasome.
The protein, which has a molecular weight of 27 kDa was first defined by high resolution two dimetional PAGE. Standard immunohistochemical techniques have demonstrated the presence of PGP9.5 in neurons ａnd nerve fibers at all levels of the central ａnd peripheral nervous system, in many neurodcrine cells, in segments of the renal tubules, in spermatogonia ａnd leydig cells of the testis, in ova ａnd in some cells of both the pregnant ａnd non pregnant corpus luteum. A point mutation （I93M） in UCHL1 is implicated as the cause of Parkinson＇s disease in one kindred. On the other hand, a polymorphism （S18Y） in UCHL1 has been found to be associated with a reduced risk for Parkinson＇s disease. Furthermore, UCHL1 is associated with the Alzheimer＇s disease, ａnd required for normal synaptic ａnd cognitive function. Description PGP9.5 Human Recombinant full length protein expressed in E.coli, shows a 36 kDa band on SDS-PAGE.
The PGP9.5 is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation PGP9.5 in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Applications ? ELISA
? Inhibition Assays
? Western Blotting. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
慧嘉生物您实验身边的好伙伴
PGP9.5 Human/ 重组人泛素羧基末端水解酶同工酶L1
产品编号：PRO-576
产品规格：5μg/25μg/1mg
Synonyms Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1, EC 3.4.19.12, Ubiquitin thioesterase L1, Neuron cytoplasmic protein 9.5, PGP 9.5, UCHL1, PGP9.5, PARK5. Introduction UCHL1 （PGP9.5） belongs to a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to produce the ubiquitin monomer. Protein Gene Product （PGP9.5） is a neuron specific protein, structurally ａnd immunologically distinct from neuron specific enolase. Human UCHL1 ａnd UCHL3 have an extremely complicated knot structure for a protein, with five knot crossings. It is considered that the knot structure may increase a protein＇s resistance to degradation in the proteasome.
The protein, which has a molecular weight of 27 kDa was first defined by high resolution two dimetional PAGE. Standard immunohistochemical techniques have demonstrated the presence of PGP9.5 in neurons ａnd nerve fibers at all levels of the central ａnd peripheral nervous system, in many neurodcrine cells, in segments of the renal tubules, in spermatogonia ａnd leydig cells of the testis, in ova ａnd in some cells of both the pregnant ａnd non pregnant corpus luteum. A point mutation （I93M） in UCHL1 is implicated as the cause of Parkinson＇s disease in one kindred. On the other hand, a polymorphism （S18Y） in UCHL1 has been found to be associated with a reduced risk for Parkinson＇s disease. Furthermore, UCHL1 is associated with the Alzheimer＇s disease, ａnd required for normal synaptic ａnd cognitive function. Description PGP9.5 Human Recombinant full length protein expressed in E.coli, shows a 36 kDa band on SDS-PAGE.
The PGP9.5 is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation PGP9.5 in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Applications ? ELISA
? Inhibition Assays
? Western Blotting. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
慧嘉生物您实验身边的好伙伴
PGP9.5 Human/ 重组人泛素羧基末端水解酶同工酶L1
产品编号：PRO-576
产品规格：5μg/25μg/1mg
Synonyms Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1, EC 3.4.19.12, Ubiquitin thioesterase L1, Neuron cytoplasmic protein 9.5, PGP 9.5, UCHL1, PGP9.5, PARK5. Introduction UCHL1 （PGP9.5） belongs to a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to produce the ubiquitin monomer. Protein Gene Product （PGP9.5） is a neuron specific protein, structurally ａnd immunologically distinct from neuron specific enolase. Human UCHL1 ａnd UCHL3 have an extremely complicated knot structure for a protein, with five knot crossings. It is considered that the knot structure may increase a protein＇s resistance to degradation in the proteasome.
The protein, which has a molecular weight of 27 kDa was first defined by high resolution two dimetional PAGE. Standard immunohistochemical techniques have demonstrated the presence of PGP9.5 in neurons ａnd nerve fibers at all levels of the central ａnd peripheral nervous system, in many neurodcrine cells, in segments of the renal tubules, in spermatogonia ａnd leydig cells of the testis, in ova ａnd in some cells of both the pregnant ａnd non pregnant corpus luteum. A point mutation （I93M） in UCHL1 is implicated as the cause of Parkinson＇s disease in one kindred. On the other hand, a polymorphism （S18Y） in UCHL1 has been found to be associated with a reduced risk for Parkinson＇s disease. Furthermore, UCHL1 is associated with the Alzheimer＇s disease, ａnd required for normal synaptic ａnd cognitive function. Description PGP9.5 Human Recombinant full length protein expressed in E.coli, shows a 36 kDa band on SDS-PAGE.
The PGP9.5 is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation PGP9.5 in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Applications ? ELISA
? Inhibition Assays
? Western Blotting. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
慧嘉生物您实验身边的好伙伴
PGP9.5 Human/ 重组人泛素羧基末端水解酶同工酶L1
产品编号：PRO-576
产品规格：5μg/25μg/1mg
Synonyms Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1, EC 3.4.19.12, Ubiquitin thioesterase L1, Neuron cytoplasmic protein 9.5, PGP 9.5, UCHL1, PGP9.5, PARK5. Introduction UCHL1 （PGP9.5） belongs to a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to produce the ubiquitin monomer. Protein Gene Product （PGP9.5） is a neuron specific protein, structurally ａnd immunologically distinct from neuron specific enolase. Human UCHL1 ａnd UCHL3 have an extremely complicated knot structure for a protein, with five knot crossings. It is considered that the knot structure may increase a protein＇s resistance to degradation in the proteasome.
The protein, which has a molecular weight of 27 kDa was first defined by high resolution two dimetional PAGE. Standard immunohistochemical techniques have demonstrated the presence of PGP9.5 in neurons ａnd nerve fibers at all levels of the central ａnd peripheral nervous system, in many neurodcrine cells, in segments of the renal tubules, in spermatogonia ａnd leydig cells of the testis, in ova ａnd in some cells of both the pregnant ａnd non pregnant corpus luteum. A point mutation （I93M） in UCHL1 is implicated as the cause of Parkinson＇s disease in one kindred. On the other hand, a polymorphism （S18Y） in UCHL1 has been found to be associated with a reduced risk for Parkinson＇s disease. Furthermore, UCHL1 is associated with the Alzheimer＇s disease, ａnd required for normal synaptic ａnd cognitive function. Description PGP9.5 Human Recombinant full length protein expressed in E.coli, shows a 36 kDa band on SDS-PAGE.
The PGP9.5 is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation PGP9.5 in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Applications ? ELISA
? Inhibition Assays
? Western Blotting. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
慧嘉生物您实验身边的好伙伴
PGP9.5 Human/ 重组人泛素羧基末端水解酶同工酶L1
产品编号：PRO-576
产品规格：5μg/25μg/1mg
Synonyms Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1, EC 3.4.19.12, Ubiquitin thioesterase L1, Neuron cytoplasmic protein 9.5, PGP 9.5, UCHL1, PGP9.5, PARK5. Introduction UCHL1 （PGP9.5） belongs to a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to produce the ubiquitin monomer. Protein Gene Product （PGP9.5） is a neuron specific protein, structurally ａnd immunologically distinct from neuron specific enolase. Human UCHL1 ａnd UCHL3 have an extremely complicated knot structure for a protein, with five knot crossings. It is considered that the knot structure may increase a protein＇s resistance to degradation in the proteasome.
The protein, which has a molecular weight of 27 kDa was first defined by high resolution two dimetional PAGE. Standard immunohistochemical techniques have demonstrated the presence of PGP9.5 in neurons ａnd nerve fibers at all levels of the central ａnd peripheral nervous system, in many neurodcrine cells, in segments of the renal tubules, in spermatogonia ａnd leydig cells of the testis, in ova ａnd in some cells of both the pregnant ａnd non pregnant corpus luteum. A point mutation （I93M） in UCHL1 is implicated as the cause of Parkinson＇s disease in one kindred. On the other hand, a polymorphism （S18Y） in UCHL1 has been found to be associated with a reduced risk for Parkinson＇s disease. Furthermore, UCHL1 is associated with the Alzheimer＇s disease, ａnd required for normal synaptic ａnd cognitive function. Description PGP9.5 Human Recombinant full length protein expressed in E.coli, shows a 36 kDa band on SDS-PAGE.
The PGP9.5 is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation PGP9.5 in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Applications ? ELISA
? Inhibition Assays
? Western Blotting. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
慧嘉生物您实验身边的好伙伴
PGP9.5 Human/ 重组人泛素羧基末端水解酶同工酶L1
产品编号：PRO-576
产品规格：5μg/25μg/1mg
Synonyms Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1, EC 3.4.19.12, Ubiquitin thioesterase L1, Neuron cytoplasmic protein 9.5, PGP 9.5, UCHL1, PGP9.5, PARK5. Introduction UCHL1 （PGP9.5） belongs to a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to produce the ubiquitin monomer. Protein Gene Product （PGP9.5） is a neuron specific protein, structurally ａnd immunologically distinct from neuron specific enolase. Human UCHL1 ａnd UCHL3 have an extremely complicated knot structure for a protein, with five knot crossings. It is considered that the knot structure may increase a protein＇s resistance to degradation in the proteasome.
The protein, which has a molecular weight of 27 kDa was first defined by high resolution two dimetional PAGE. Standard immunohistochemical techniques have demonstrated the presence of PGP9.5 in neurons ａnd nerve fibers at all levels of the central ａnd peripheral nervous system, in many neurodcrine cells, in segments of the renal tubules, in spermatogonia ａnd leydig cells of the testis, in ova ａnd in some cells of both the pregnant ａnd non pregnant corpus luteum. A point mutation （I93M） in UCHL1 is implicated as the cause of Parkinson＇s disease in one kindred. On the other hand, a polymorphism （S18Y） in UCHL1 has been found to be associated with a reduced risk for Parkinson＇s disease. Furthermore, UCHL1 is associated with the Alzheimer＇s disease, ａnd required for normal synaptic ａnd cognitive function. Description PGP9.5 Human Recombinant full length protein expressed in E.coli, shows a 36 kDa band on SDS-PAGE.
The PGP9.5 is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation PGP9.5 in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Applications ? ELISA
? Inhibition Assays
? Western Blotting. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
慧嘉生物您实验身边的好伙伴
PGP9.5 Human/ 重组人泛素羧基末端水解酶同工酶L1
产品编号：PRO-576
产品规格：5μg/25μg/1mg
Synonyms Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1, EC 3.4.19.12, Ubiquitin thioesterase L1, Neuron cytoplasmic protein 9.5, PGP 9.5, UCHL1, PGP9.5, PARK5. Introduction UCHL1 （PGP9.5） belongs to a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to produce the ubiquitin monomer. Protein Gene Product （PGP9.5） is a neuron specific protein, structurally ａnd immunologically distinct from neuron specific enolase. Human UCHL1 ａnd UCHL3 have an extremely complicated knot structure for a protein, with five knot crossings. It is considered that the knot structure may increase a protein＇s resistance to degradation in the proteasome.
The protein, which has a molecular weight of 27 kDa was first defined by high resolution two dimetional PAGE. Standard immunohistochemical techniques have demonstrated the presence of PGP9.5 in neurons ａnd nerve fibers at all levels of the central ａnd peripheral nervous system, in many neurodcrine cells, in segments of the renal tubules, in spermatogonia ａnd leydig cells of the testis, in ova ａnd in some cells of both the pregnant ａnd non pregnant corpus luteum. A point mutation （I93M） in UCHL1 is implicated as the cause of Parkinson＇s disease in one kindred. On the other hand, a polymorphism （S18Y） in UCHL1 has been found to be associated with a reduced risk for Parkinson＇s disease. Furthermore, UCHL1 is associated with the Alzheimer＇s disease, ａnd required for normal synaptic ａnd cognitive function. Description PGP9.5 Human Recombinant full length protein expressed in E.coli, shows a 36 kDa band on SDS-PAGE.
The PGP9.5 is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation PGP9.5 in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Applications ? ELISA
? Inhibition Assays
? Western Blotting. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
慧嘉生物您实验身边的好伙伴
PGP9.5 Human/ 重组人泛素羧基末端水解酶同工酶L1
产品编号：PRO-576
产品规格：5μg/25μg/1mg
Synonyms Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1, EC 3.4.19.12, Ubiquitin thioesterase L1, Neuron cytoplasmic protein 9.5, PGP 9.5, UCHL1, PGP9.5, PARK5. Introduction UCHL1 （PGP9.5） belongs to a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to produce the ubiquitin monomer. Protein Gene Product （PGP9.5） is a neuron specific protein, structurally ａnd immunologically distinct from neuron specific enolase. Human UCHL1 ａnd UCHL3 have an extremely complicated knot structure for a protein, with five knot crossings. It is considered that the knot structure may increase a protein＇s resistance to degradation in the proteasome.
The protein, which has a molecular weight of 27 kDa was first defined by high resolution two dimetional PAGE. Standard immunohistochemical techniques have demonstrated the presence of PGP9.5 in neurons ａnd nerve fibers at all levels of the central ａnd peripheral nervous system, in many neurodcrine cells, in segments of the renal tubules, in spermatogonia ａnd leydig cells of the testis, in ova ａnd in some cells of both the pregnant ａnd non pregnant corpus luteum. A point mutation （I93M） in UCHL1 is implicated as the cause of Parkinson＇s disease in one kindred. On the other hand, a polymorphism （S18Y） in UCHL1 has been found to be associated with a reduced risk for Parkinson＇s disease. Furthermore, UCHL1 is associated with the Alzheimer＇s disease, ａnd required for normal synaptic ａnd cognitive function. Description PGP9.5 Human Recombinant full length protein expressed in E.coli, shows a 36 kDa band on SDS-PAGE.
The PGP9.5 is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation PGP9.5 in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Applications ? ELISA
? Inhibition Assays
? Western Blotting. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
慧嘉生物您实验身边的好伙伴
PGP9.5 Human/ 重组人泛素羧基末端水解酶同工酶L1
产品编号：PRO-576
产品规格：5μg/25μg/1mg
Synonyms Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1, EC 3.4.19.12, Ubiquitin thioesterase L1, Neuron cytoplasmic protein 9.5, PGP 9.5, UCHL1, PGP9.5, PARK5. Introduction UCHL1 （PGP9.5） belongs to a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to produce the ubiquitin monomer. Protein Gene Product （PGP9.5） is a neuron specific protein, structurally ａnd immunologically distinct from neuron specific enolase. Human UCHL1 ａnd UCHL3 have an extremely complicated knot structure for a protein, with five knot crossings. It is considered that the knot structure may increase a protein＇s resistance to degradation in the proteasome.
The protein, which has a molecular weight of 27 kDa was first defined by high resolution two dimetional PAGE. Standard immunohistochemical techniques have demonstrated the presence of PGP9.5 in neurons ａnd nerve fibers at all levels of the central ａnd peripheral nervous system, in many neurodcrine cells, in segments of the renal tubules, in spermatogonia ａnd leydig cells of the testis, in ova ａnd in some cells of both the pregnant ａnd non pregnant corpus luteum. A point mutation （I93M） in UCHL1 is implicated as the cause of Parkinson＇s disease in one kindred. On the other hand, a polymorphism （S18Y） in UCHL1 has been found to be associated with a reduced risk for Parkinson＇s disease. Furthermore, UCHL1 is associated with the Alzheimer＇s disease, ａnd required for normal synaptic ａnd cognitive function. Description PGP9.5 Human Recombinant full length protein expressed in E.coli, shows a 36 kDa band on SDS-PAGE.
The PGP9.5 is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation PGP9.5 in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Applications ? ELISA
? Inhibition Assays
? Western Blotting. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
慧嘉生物您实验身边的好伙伴
PGP9.5 Human/ 重组人泛素羧基末端水解酶同工酶L1
产品编号：PRO-576
产品规格：5μg/25μg/1mg
Synonyms Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1, EC 3.4.19.12, Ubiquitin thioesterase L1, Neuron cytoplasmic protein 9.5, PGP 9.5, UCHL1, PGP9.5, PARK5. Introduction UCHL1 （PGP9.5） belongs to a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to produce the ubiquitin monomer. Protein Gene Product （PGP9.5） is a neuron specific protein, structurally ａnd immunologically distinct from neuron specific enolase. Human UCHL1 ａnd UCHL3 have an extremely complicated knot structure for a protein, with five knot crossings. It is considered that the knot structure may increase a protein＇s resistance to degradation in the proteasome.
The protein, which has a molecular weight of 27 kDa was first defined by high resolution two dimetional PAGE. Standard immunohistochemical techniques have demonstrated the presence of PGP9.5 in neurons ａnd nerve fibers at all levels of the central ａnd peripheral nervous system, in many neurodcrine cells, in segments of the renal tubules, in spermatogonia ａnd leydig cells of the testis, in ova ａnd in some cells of both the pregnant ａnd non pregnant corpus luteum. A point mutation （I93M） in UCHL1 is implicated as the cause of Parkinson＇s disease in one kindred. On the other hand, a polymorphism （S18Y） in UCHL1 has been found to be associated with a reduced risk for Parkinson＇s disease. Furthermore, UCHL1 is associated with the Alzheimer＇s disease, ａnd required for normal synaptic ａnd cognitive function. Description PGP9.5 Human Recombinant full length protein expressed in E.coli, shows a 36 kDa band on SDS-PAGE.
The PGP9.5 is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation PGP9.5 in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Applications ? ELISA
? Inhibition Assays
? Western Blotting. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
慧嘉生物您实验身边的好伙伴
PGP9.5 Human/ 重组人泛素羧基末端水解酶同工酶L1
产品编号：PRO-576
产品规格：5μg/25μg/1mg
Synonyms Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1, EC 3.4.19.12, Ubiquitin thioesterase L1, Neuron cytoplasmic protein 9.5, PGP 9.5, UCHL1, PGP9.5, PARK5. Introduction UCHL1 （PGP9.5） belongs to a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to produce the ubiquitin monomer. Protein Gene Product （PGP9.5） is a neuron specific protein, structurally ａnd immunologically distinct from neuron specific enolase. Human UCHL1 ａnd UCHL3 have an extremely complicated knot structure for a protein, with five knot crossings. It is considered that the knot structure may increase a protein＇s resistance to degradation in the proteasome.
The protein, which has a molecular weight of 27 kDa was first defined by high resolution two dimetional PAGE. Standard immunohistochemical techniques have demonstrated the presence of PGP9.5 in neurons ａnd nerve fibers at all levels of the central ａnd peripheral nervous system, in many neurodcrine cells, in segments of the renal tubules, in spermatogonia ａnd leydig cells of the testis, in ova ａnd in some cells of both the pregnant ａnd non pregnant corpus luteum. A point mutation （I93M） in UCHL1 is implicated as the cause of Parkinson＇s disease in one kindred. On the other hand, a polymorphism （S18Y） in UCHL1 has been found to be associated with a reduced risk for Parkinson＇s disease. Furthermore, UCHL1 is associated with the Alzheimer＇s disease, ａnd required for normal synaptic ａnd cognitive function. Description PGP9.5 Human Recombinant full length protein expressed in E.coli, shows a 36 kDa band on SDS-PAGE.
The PGP9.5 is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation PGP9.5 in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Applications ? ELISA
? Inhibition Assays
? Western Blotting. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
慧嘉生物您实验身边的好伙伴
PGP9.5 Human/ 重组人泛素羧基末端水解酶同工酶L1
产品编号：PRO-576
产品规格：5μg/25μg/1mg
Synonyms Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1, EC 3.4.19.12, Ubiquitin thioesterase L1, Neuron cytoplasmic protein 9.5, PGP 9.5, UCHL1, PGP9.5, PARK5. Introduction UCHL1 （PGP9.5） belongs to a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to produce the ubiquitin monomer. Protein Gene Product （PGP9.5） is a neuron specific protein, structurally ａnd immunologically distinct from neuron specific enolase. Human UCHL1 ａnd UCHL3 have an extremely complicated knot structure for a protein, with five knot crossings. It is considered that the knot structure may increase a protein＇s resistance to degradation in the proteasome.
The protein, which has a molecular weight of 27 kDa was first defined by high resolution two dimetional PAGE. Standard immunohistochemical techniques have demonstrated the presence of PGP9.5 in neurons ａnd nerve fibers at all levels of the central ａnd peripheral nervous system, in many neurodcrine cells, in segments of the renal tubules, in spermatogonia ａnd leydig cells of the testis, in ova ａnd in some cells of both the pregnant ａnd non pregnant corpus luteum. A point mutation （I93M） in UCHL1 is implicated as the cause of Parkinson＇s disease in one kindred. On the other hand, a polymorphism （S18Y） in UCHL1 has been found to be associated with a reduced risk for Parkinson＇s disease. Furthermore, UCHL1 is associated with the Alzheimer＇s disease, ａnd required for normal synaptic ａnd cognitive function. Description PGP9.5 Human Recombinant full length protein expressed in E.coli, shows a 36 kDa band on SDS-PAGE.
The PGP9.5 is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation PGP9.5 in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Applications ? ELISA
? Inhibition Assays
? Western Blotting. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
慧嘉生物您实验身边的好伙伴
PGP9.5 Human/ 重组人泛素羧基末端水解酶同工酶L1
产品编号：PRO-576
产品规格：5μg/25μg/1mg
Synonyms Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1, EC 3.4.19.12, Ubiquitin thioesterase L1, Neuron cytoplasmic protein 9.5, PGP 9.5, UCHL1, PGP9.5, PARK5. Introduction UCHL1 （PGP9.5） belongs to a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to produce the ubiquitin monomer. Protein Gene Product （PGP9.5） is a neuron specific protein, structurally ａnd immunologically distinct from neuron specific enolase. Human UCHL1 ａnd UCHL3 have an extremely complicated knot structure for a protein, with five knot crossings. It is considered that the knot structure may increase a protein＇s resistance to degradation in the proteasome.
The protein, which has a molecular weight of 27 kDa was first defined by high resolution two dimetional PAGE. Standard immunohistochemical techniques have demonstrated the presence of PGP9.5 in neurons ａnd nerve fibers at all levels of the central ａnd peripheral nervous system, in many neurodcrine cells, in segments of the renal tubules, in spermatogonia ａnd leydig cells of the testis, in ova ａnd in some cells of both the pregnant ａnd non pregnant corpus luteum. A point mutation （I93M） in UCHL1 is implicated as the cause of Parkinson＇s disease in one kindred. On the other hand, a polymorphism （S18Y） in UCHL1 has been found to be associated with a reduced risk for Parkinson＇s disease. Furthermore, UCHL1 is associated with the Alzheimer＇s disease, ａnd required for normal synaptic ａnd cognitive function. Description PGP9.5 Human Recombinant full length protein expressed in E.coli, shows a 36 kDa band on SDS-PAGE.
The PGP9.5 is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation PGP9.5 in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Applications ? ELISA
? Inhibition Assays
? Western Blotting. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
慧嘉生物您实验身边的好伙伴
PGP9.5 Human/ 重组人泛素羧基末端水解酶同工酶L1
产品编号：PRO-576
产品规格：5μg/25μg/1mg
Synonyms Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1, EC 3.4.19.12, Ubiquitin thioesterase L1, Neuron cytoplasmic protein 9.5, PGP 9.5, UCHL1, PGP9.5, PARK5. Introduction UCHL1 （PGP9.5） belongs to a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to produce the ubiquitin monomer. Protein Gene Product （PGP9.5） is a neuron specific protein, structurally ａnd immunologically distinct from neuron specific enolase. Human UCHL1 ａnd UCHL3 have an extremely complicated knot structure for a protein, with five knot crossings. It is considered that the knot structure may increase a protein＇s resistance to degradation in the proteasome.
The protein, which has a molecular weight of 27 kDa was first defined by high resolution two dimetional PAGE. Standard immunohistochemical techniques have demonstrated the presence of PGP9.5 in neurons ａnd nerve fibers at all levels of the central ａnd peripheral nervous system, in many neurodcrine cells, in segments of the renal tubules, in spermatogonia ａnd leydig cells of the testis, in ova ａnd in some cells of both the pregnant ａnd non pregnant corpus luteum. A point mutation （I93M） in UCHL1 is implicated as the cause of Parkinson＇s disease in one kindred. On the other hand, a polymorphism （S18Y） in UCHL1 has been found to be associated with a reduced risk for Parkinson＇s disease. Furthermore, UCHL1 is associated with the Alzheimer＇s disease, ａnd required for normal synaptic ａnd cognitive function. Description PGP9.5 Human Recombinant full length protein expressed in E.coli, shows a 36 kDa band on SDS-PAGE.
The PGP9.5 is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation PGP9.5 in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Applications ? ELISA
? Inhibition Assays
? Western Blotting. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
慧嘉生物您实验身边的好伙伴
PGP9.5 Human/ 重组人泛素羧基末端水解酶同工酶L1
产品编号：PRO-576
产品规格：5μg/25μg/1mg
Synonyms Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1, EC 3.4.19.12, Ubiquitin thioesterase L1, Neuron cytoplasmic protein 9.5, PGP 9.5, UCHL1, PGP9.5, PARK5. Introduction UCHL1 （PGP9.5） belongs to a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to produce the ubiquitin monomer. Protein Gene Product （PGP9.5） is a neuron specific protein, structurally ａnd immunologically distinct from neuron specific enolase. Human UCHL1 ａnd UCHL3 have an extremely complicated knot structure for a protein, with five knot crossings. It is considered that the knot structure may increase a protein＇s resistance to degradation in the proteasome.
The protein, which has a molecular weight of 27 kDa was first defined by high resolution two dimetional PAGE. Standard immunohistochemical techniques have demonstrated the presence of PGP9.5 in neurons ａnd nerve fibers at all levels of the central ａnd peripheral nervous system, in many neurodcrine cells, in segments of the renal tubules, in spermatogonia ａnd leydig cells of the testis, in ova ａnd in some cells of both the pregnant ａnd non pregnant corpus luteum. A point mutation （I93M） in UCHL1 is implicated as the cause of Parkinson＇s disease in one kindred. On the other hand, a polymorphism （S18Y） in UCHL1 has been found to be associated with a reduced risk for Parkinson＇s disease. Furthermore, UCHL1 is associated with the Alzheimer＇s disease, ａnd required for normal synaptic ａnd cognitive function. Description PGP9.5 Human Recombinant full length protein expressed in E.coli, shows a 36 kDa band on SDS-PAGE.
The PGP9.5 is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation PGP9.5 in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Applications ? ELISA
? Inhibition Assays
? Western Blotting. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
慧嘉生物您实验身边的好伙伴
PGP9.5 Human/ 重组人泛素羧基末端水解酶同工酶L1
产品编号：PRO-576
产品规格：5μg/25μg/1mg
Synonyms Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1, EC 3.4.19.12, Ubiquitin thioesterase L1, Neuron cytoplasmic protein 9.5, PGP 9.5, UCHL1, PGP9.5, PARK5. Introduction UCHL1 （PGP9.5） belongs to a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to produce the ubiquitin monomer. Protein Gene Product （PGP9.5） is a neuron specific protein, structurally ａnd immunologically distinct from neuron specific enolase. Human UCHL1 ａnd UCHL3 have an extremely complicated knot structure for a protein, with five knot crossings. It is considered that the knot structure may increase a protein＇s resistance to degradation in the proteasome.
The protein, which has a molecular weight of 27 kDa was first defined by high resolution two dimetional PAGE. Standard immunohistochemical techniques have demonstrated the presence of PGP9.5 in neurons ａnd nerve fibers at all levels of the central ａnd peripheral nervous system, in many neurodcrine cells, in segments of the renal tubules, in spermatogonia ａnd leydig cells of the testis, in ova ａnd in some cells of both the pregnant ａnd non pregnant corpus luteum. A point mutation （I93M） in UCHL1 is implicated as the cause of Parkinson＇s disease in one kindred. On the other hand, a polymorphism （S18Y） in UCHL1 has been found to be associated with a reduced risk for Parkinson＇s disease. Furthermore, UCHL1 is associated with the Alzheimer＇s disease, ａnd required for normal synaptic ａnd cognitive function. Description PGP9.5 Human Recombinant full length protein expressed in E.coli, shows a 36 kDa band on SDS-PAGE.
The PGP9.5 is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation PGP9.5 in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Applications ? ELISA
? Inhibition Assays
? Western Blotting. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
慧嘉生物您实验身边的好伙伴
PGP9.5 Human/ 重组人泛素羧基末端水解酶同工酶L1
产品编号：PRO-576
产品规格：5μg/25μg/1mg
Synonyms Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1, EC 3.4.19.12, Ubiquitin thioesterase L1, Neuron cytoplasmic protein 9.5, PGP 9.5, UCHL1, PGP9.5, PARK5. Introduction UCHL1 （PGP9.5） belongs to a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to produce the ubiquitin monomer. Protein Gene Product （PGP9.5） is a neuron specific protein, structurally ａnd immunologically distinct from neuron specific enolase. Human UCHL1 ａnd UCHL3 have an extremely complicated knot structure for a protein, with five knot crossings. It is considered that the knot structure may increase a protein＇s resistance to degradation in the proteasome.
The protein, which has a molecular weight of 27 kDa was first defined by high resolution two dimetional PAGE. Standard immunohistochemical techniques have demonstrated the presence of PGP9.5 in neurons ａnd nerve fibers at all levels of the central ａnd peripheral nervous system, in many neurodcrine cells, in segments of the renal tubules, in spermatogonia ａnd leydig cells of the testis, in ova ａnd in some cells of both the pregnant ａnd non pregnant corpus luteum. A point mutation （I93M） in UCHL1 is implicated as the cause of Parkinson＇s disease in one kindred. On the other hand, a polymorphism （S18Y） in UCHL1 has been found to be associated with a reduced risk for Parkinson＇s disease. Furthermore, UCHL1 is associated with the Alzheimer＇s disease, ａnd required for normal synaptic ａnd cognitive function. Description PGP9.5 Human Recombinant full length protein expressed in E.coli, shows a 36 kDa band on SDS-PAGE.
The PGP9.5 is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation PGP9.5 in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Applications ? ELISA
? Inhibition Assays
? Western Blotting. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
慧嘉生物您实验身边的好伙伴
PGP9.5 Human/ 重组人泛素羧基末端水解酶同工酶L1
产品编号：PRO-576
产品规格：5μg/25μg/1mg
Synonyms Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1, EC 3.4.19.12, Ubiquitin thioesterase L1, Neuron cytoplasmic protein 9.5, PGP 9.5, UCHL1, PGP9.5, PARK5. Introduction UCHL1 （PGP9.5） belongs to a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to produce the ubiquitin monomer. Protein Gene Product （PGP9.5） is a neuron specific protein, structurally ａnd immunologically distinct from neuron specific enolase. Human UCHL1 ａnd UCHL3 have an extremely complicated knot structure for a protein, with five knot crossings. It is considered that the knot structure may increase a protein＇s resistance to degradation in the proteasome.
The protein, which has a molecular weight of 27 kDa was first defined by high resolution two dimetional PAGE. Standard immunohistochemical techniques have demonstrated the presence of PGP9.5 in neurons ａnd nerve fibers at all levels of the central ａnd peripheral nervous system, in many neurodcrine cells, in segments of the renal tubules, in spermatogonia ａnd leydig cells of the testis, in ova ａnd in some cells of both the pregnant ａnd non pregnant corpus luteum. A point mutation （I93M） in UCHL1 is implicated as the cause of Parkinson＇s disease in one kindred. On the other hand, a polymorphism （S18Y） in UCHL1 has been found to be associated with a reduced risk for Parkinson＇s disease. Furthermore, UCHL1 is associated with the Alzheimer＇s disease, ａnd required for normal synaptic ａnd cognitive function. Description PGP9.5 Human Recombinant full length protein expressed in E.coli, shows a 36 kDa band on SDS-PAGE.
The PGP9.5 is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation PGP9.5 in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Applications ? ELISA
? Inhibition Assays
? Western Blotting. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
慧嘉生物您实验身边的好伙伴
PGP9.5 Human/ 重组人泛素羧基末端水解酶同工酶L1
产品编号：PRO-576
产品规格：5μg/25μg/1mg
Synonyms Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1, EC 3.4.19.12, Ubiquitin thioesterase L1, Neuron cytoplasmic protein 9.5, PGP 9.5, UCHL1, PGP9.5, PARK5. Introduction UCHL1 （PGP9.5） belongs to a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to produce the ubiquitin monomer. Protein Gene Product （PGP9.5） is a neuron specific protein, structurally ａnd immunologically distinct from neuron specific enolase. Human UCHL1 ａnd UCHL3 have an extremely complicated knot structure for a protein, with five knot crossings. It is considered that the knot structure may increase a protein＇s resistance to degradation in the proteasome.
The protein, which has a molecular weight of 27 kDa was first defined by high resolution two dimetional PAGE. Standard immunohistochemical techniques have demonstrated the presence of PGP9.5 in neurons ａnd nerve fibers at all levels of the central ａnd peripheral nervous system, in many neurodcrine cells, in segments of the renal tubules, in spermatogonia ａnd leydig cells of the testis, in ova ａnd in some cells of both the pregnant ａnd non pregnant corpus luteum. A point mutation （I93M） in UCHL1 is implicated as the cause of Parkinson＇s disease in one kindred. On the other hand, a polymorphism （S18Y） in UCHL1 has been found to be associated with a reduced risk for Parkinson＇s disease. Furthermore, UCHL1 is associated with the Alzheimer＇s disease, ａnd required for normal synaptic ａnd cognitive function. Description PGP9.5 Human Recombinant full length protein expressed in E.coli, shows a 36 kDa band on SDS-PAGE.
The PGP9.5 is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation PGP9.5 in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Applications ? ELISA
? Inhibition Assays
? Western Blotting. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
慧嘉生物您实验身边的好伙伴
PGP9.5 Human/ 重组人泛素羧基末端水解酶同工酶L1
产品编号：PRO-576
产品规格：5μg/25μg/1mg
Synonyms Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1, EC 3.4.19.12, Ubiquitin thioesterase L1, Neuron cytoplasmic protein 9.5, PGP 9.5, UCHL1, PGP9.5, PARK5. Introduction UCHL1 （PGP9.5） belongs to a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to produce the ubiquitin monomer. Protein Gene Product （PGP9.5） is a neuron specific protein, structurally ａnd immunologically distinct from neuron specific enolase. Human UCHL1 ａnd UCHL3 have an extremely complicated knot structure for a protein, with five knot crossings. It is considered that the knot structure may increase a protein＇s resistance to degradation in the proteasome.
The protein, which has a molecular weight of 27 kDa was first defined by high resolution two dimetional PAGE. Standard immunohistochemical techniques have demonstrated the presence of PGP9.5 in neurons ａnd nerve fibers at all levels of the central ａnd peripheral nervous system, in many neurodcrine cells, in segments of the renal tubules, in spermatogonia ａnd leydig cells of the testis, in ova ａnd in some cells of both the pregnant ａnd non pregnant corpus luteum. A point mutation （I93M） in UCHL1 is implicated as the cause of Parkinson＇s disease in one kindred. On the other hand, a polymorphism （S18Y） in UCHL1 has been found to be associated with a reduced risk for Parkinson＇s disease. Furthermore, UCHL1 is associated with the Alzheimer＇s disease, ａnd required for normal synaptic ａnd cognitive function. Description PGP9.5 Human Recombinant full length protein expressed in E.coli, shows a 36 kDa band on SDS-PAGE.
The PGP9.5 is purified by proprietary chromatographic techniques. Source Escherichia Coli. Physical Appearance Sterile Filtered clear solution. Formulation PGP9.5 in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol. Stability Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles. Applications ? ELISA
? Inhibition Assays
? Western Blotting. Usage Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
慧嘉生物您实验身边的好伙伴
PGP9.5 Human/ 重组人泛素羧基末端水解酶同工酶L1
产品编号：PRO-576
产品规格：5μg/25μg/1mg
产品规格：5μg/25μg/1mg
| Synonyms | Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1, EC 3.4.19.12, Ubiquitin thioesterase L1, Neuron cytoplasmic protein 9.5, PGP 9.5, UCHL1, PGP9.5, PARK5. |
| Introduction | UCHL1 （PGP9.5） belongs to a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to produce the ubiquitin monomer. Protein Gene Product （PGP9.5） is a neuron specific protein, structurally ａnd immunologically distinct from neuron specific enolase. Human UCHL1 ａnd UCHL3 have an extremely complicated knot structure for a protein, with five knot crossings. It is considered that the knot structure may increase a protein＇s resistance to degradation in the proteasome. The protein, which has a molecular weight of 27 kDa was first defined by high resolution two dimetional PAGE. Standard immunohistochemical techniques have demonstrated the presence of PGP9.5 in neurons ａnd nerve fibers at all levels of the central ａnd peripheral nervous system, in many neurodcrine cells, in segments of the renal tubules, in spermatogonia ａnd leydig cells of the testis, in ova ａnd in some cells of both the pregnant ａnd non pregnant corpus luteum. A point mutation （I93M） in UCHL1 is implicated as the cause of Parkinson＇s disease in one kindred. On the other hand, a polymorphism （S18Y） in UCHL1 has been found to be associated with a reduced risk for Parkinson＇s disease. Furthermore, UCHL1 is associated with the Alzheimer＇s disease, ａnd required for normal synaptic ａnd cognitive function. |
| Description | PGP9.5 Human Recombinant full length protein expressed in E.coli, shows a 36 kDa band on SDS-PAGE. The PGP9.5 is purified by proprietary chromatographic techniques. |
| Source | Escherichia Coli. |
| Physical Appearance | Sterile Filtered clear solution. |
| Formulation | PGP9.5 in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol. |
| Stability | Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months. Please prevent freeze-thaw cycles. |
| Applications | ? ELISA ? Inhibition Assays ? Western Blotting. |
| Usage | Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
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