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SERPINE1 Human/人纤溶酶原激活物抑制剂-1

点击次数:165发布时间:2012/10/30 19:22:58

SERPINE1 Human/人纤溶酶原激活物抑制剂-1

更新日期:2024/10/16 16:00:43

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简单介绍:SERPINE1 Human/人纤溶酶原激活物抑制剂-1

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SERPINE1 Human/人纤溶酶原激活物抑制剂-1

产品编号:ENZ-356
产品规格:2μg/10μg/1mg
 
 
 
Synonyms PAI-1, PAI1, PLANH1, SERPINE1, PAIE, PLASMINOGEN ACTIVATOR INHIBITOR, BETA-MIGRATING ENDOTHELIAL-CELL-DERIVED TYPE.
Introduction Plasminogen activator inhibitor-1 is the principal inhibitor of tissue plasminogen activator(tPA) and urokinase(uPA), the activators of plasminogenand hence fibrinolysis(the physiological breakdown of blood clots). It is a serine protease inhibitor(serpin) protein (SERPINE1). The other PAI, plasminogen activator inhibitor-2(PAI-2) is secreted by the placentaand only present in significant amounts during pregnancy. In addition, protease nexinacts as an inhibitor of tPA and urokinase. PAI-1, however, is the main inhibitor of the plasminogen activators.
Description Constitutively active human plasminogen activator inhibitor 1, stable mutant 14-1B having a Molecular mass of 43 kDa. This human form of SERPINE1 contains the following four mutations: K154T, Q139L, M354I and N150H. These mutations combine to confer great stability to the otherwise labile molecule essentially locking it into the active conformation.
The SERPINE1 is purified by proprietary chromatographic techniques.
Physical Appearance Sterile Filtered clear colorless solution.
Formulation 0.05M sodium phosphate 0.1M NaCl and 1mM EDTA (pH 6.6).
Stability Human SERPINE1 although stable at 8°C celsius for 1 week, should be stored desiccated below -18°C.
Purity Greater than 95.0% as determined by(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
Usage Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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