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S100P Human/ 重组人S100钙结合蛋白P
点击次数：174发布时间：2012/10/30 19:49:16
更新日期：2024/10/16 16:00:43
所 在 地：美洲
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为客户提供“质量的产品”和“*优质的服务”
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为客户提供“质量的产品”和“*优质的服务”
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为客户提供“质量的产品”和“*优质的服务”
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为客户提供“质量的产品”和“*优质的服务”
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为客户提供“质量的产品”和“*优质的服务”
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为客户提供“质量的产品”和“*优质的服务”
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为客户提供“质量的产品”和“*优质的服务”
慧嘉生物您实验身边的好伙伴
为客户提供“质量的产品”和“*优质的服务”
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为客户提供“质量的产品”和“*优质的服务”
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为客户提供“质量的产品”和“*优质的服务”
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为客户提供“质量的产品”和“*优质的服务”
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为客户提供“质量的产品”和“*优质的服务”
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为客户提供“质量的产品”和“*优质的服务”
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为客户提供“质量的产品”和“*优质的服务”
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为客户提供“质量的产品”和“*优质的服务”
慧嘉生物您实验身边的好伙伴
为客户提供“质量的产品”和“*优质的服务”
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S100P Human/ 重组人S100钙结合蛋白P
产品编号：PRO-425
产品规格：2μg/10μg/1mg
S100P Human/ 重组人S100钙结合蛋白P
产品编号：PRO-425
产品规格：2μg/10μg/1mg
S100P Human/ 重组人S100钙结合蛋白P
产品编号：PRO-425
产品规格：2μg/10μg/1mg
S100P Human/ 重组人S100钙结合蛋白P
产品编号：PRO-425
产品规格：2μg/10μg/1mg
S100P Human/ 重组人S100钙结合蛋白P
产品编号：PRO-425
产品规格：2μg/10μg/1mg
S100P Human/ 重组人S100钙结合蛋白P
产品编号：PRO-425
产品规格：2μg/10μg/1mg
S100P Human/ 重组人S100钙结合蛋白P
产品编号：PRO-425
产品规格：2μg/10μg/1mg
S100P Human/ 重组人S100钙结合蛋白P
产品编号：PRO-425
产品规格：2μg/10μg/1mg
S100P Human/ 重组人S100钙结合蛋白P
产品编号：PRO-425
产品规格：2μg/10μg/1mg
S100P Human/ 重组人S100钙结合蛋白P
产品编号：PRO-425
产品规格：2μg/10μg/1mg
S100P Human/ 重组人S100钙结合蛋白P
产品编号：PRO-425
产品规格：2μg/10μg/1mg
S100P Human/ 重组人S100钙结合蛋白P
产品编号：PRO-425
产品规格：2μg/10μg/1mg
S100P Human/ 重组人S100钙结合蛋白P
产品编号：PRO-425
产品规格：2μg/10μg/1mg
S100P Human/ 重组人S100钙结合蛋白P
产品编号：PRO-425
产品规格：2μg/10μg/1mg
S100P Human/ 重组人S100钙结合蛋白P
产品编号：PRO-425
产品规格：2μg/10μg/1mg
S100P Human/ 重组人S100钙结合蛋白P
产品编号：PRO-425
产品规格：2μg/10μg/1mg
S100P Human/ 重组人S100钙结合蛋白P
产品编号：PRO-425
产品规格：2μg/10μg/1mg
S100P Human/ 重组人S100钙结合蛋白P
产品编号：PRO-425
产品规格：2μg/10μg/1mg
S100P Human/ 重组人S100钙结合蛋白P
产品编号：PRO-425
产品规格：2μg/10μg/1mg
S100P Human/ 重组人S100钙结合蛋白P
产品编号：PRO-425
产品规格：2μg/10μg/1mg
S100P Human/ 重组人S100钙结合蛋白P
产品编号：PRO-425
产品规格：2μg/10μg/1mg
S100P Human/ 重组人S100钙结合蛋白P
产品编号：PRO-425
产品规格：2μg/10μg/1mg
S100P Human/ 重组人S100钙结合蛋白P
产品编号：PRO-425
产品规格：2μg/10μg/1mg
S100P Human/ 重组人S100钙结合蛋白P
产品编号：PRO-425
产品规格：2μg/10μg/1mg
S100P Human/ 重组人S100钙结合蛋白P
产品编号：PRO-425
产品规格：2μg/10μg/1mg
S100P Human/ 重组人S100钙结合蛋白P
产品编号：PRO-425
产品规格：2μg/10μg/1mg
S100P Human/ 重组人S100钙结合蛋白P
产品编号：PRO-425
产品规格：2μg/10μg/1mg
S100P Human/ 重组人S100钙结合蛋白P
产品编号：PRO-425
产品规格：2μg/10μg/1mg
S100P Human/ 重组人S100钙结合蛋白P
产品编号：PRO-425
产品规格：2μg/10μg/1mg
S100P Human/ 重组人S100钙结合蛋白P
产品编号：PRO-425
产品规格：2μg/10μg/1mg
S100P Human/ 重组人S100钙结合蛋白P
产品编号：PRO-425
产品规格：2μg/10μg/1mg
产品规格：2μg/10μg/1mg
| Synonyms | Protein S100-P, S100 calcium-binding protein P, S100P, S100E, MIG9. |
| Introduction | S100P was originally described as a placental protein of 95 amino acid residues shares about 50% sequence identity with the brain S100 proteins alpha ａnd beta. S100 proteins are small dimeric members of the EF-hand superfamily of Ca（2+） binding proteins thought to participate in mediating intracellular Ca（2+） signals by binding to ａnd thereby regulating target proteins in a Ca（2+）-dependent manner. S100P in addition to binding Ca2+, also binds Zn2+ ａnd Mg2+. S100P gene is located on chromosome 4p16. S100P is dysregulated in the androgen-independent prostate cancer cell lines LNCaP-R, DU145, ａnd PC3 ａnd may play a role in the etiology of prostate cancer. In ductal hyperplasias, in situ ａnd invasive ductal carcinoma, but not in the normal tissues, S100P overexpression is an early event that might play an important role in the immortalization of human breast epithelial cells in vitro ａnd tumor progression in vivo. In NIH3T3 cells, the expression of S100P led to the presence of S100P in the culture medium, increased cellular proliferation, ａnd enhanced survival following detachment from the culture substrate or after exposure to the chemotherapeutic agent 5-flurouracil. The proliferation ａnd survival effects of S100P expression were duplicated in a time- ａnd concentration-dependent manner by extracellular addition of purified S100P to wild-type NIH3T3 cells ａnd correlated with the activation of Erks ａnd NFB. To determine the mechanisms involved in these effects, we tested the hypothesis that S100P activated RAGE （Receptor for Activated Glycation End-Products）. It was found that S100P coimmunoprecipitated with RAGE. Furthermore, the effects of S100P on cell signaling, proliferation ａnd survival were blocked by agents that interfere with RAGE including administration of an amphoterin derived peptide known to antagonize RAGE activation, anti-RAGE antibodies ａnd by expression of a dominant negative RAGE. These data suggest that S100P can act in an autocrine manner via RAGE to stimulate cell proliferation ａnd survival. |
| Description | The Recombinant Human S100P has a molecular mass of 10.4 kDa containing 95 amino acid residues of the human S100P. MTELEAAMGM IIDVFSRYSG SEGSTQTLTK GELKVLMEKE LPGFLQSGKD KDAVDKLLKD LDANGDAQVD FSEFIVFVAA ITSACHKYFE KAGLK. |
| Source | Escherichia Coli. |
| Formulation | Sterile filtered ａnd lyophilized from 0.5 mg/ml in 0.05M Phosphate buffer pH7.2, 0.1M NaCl. |
| Solubility | Add 0.2 ml of deionized H2O ａnd let the lyophilized pellet dissolve completely. |
| Stability | Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. The lyophilized protein remains stable until the expiry date when stored at -20°C. |
| Purity | Greater than 95% as determined by SDS-PAGE. |
| Applications | Western blotting. |
| Usage | Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
