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STUB1 Human/重组人STIP1同源性U-Box 包含蛋白1
点击次数：156发布时间：2012/10/31 19:48:24
更新日期：2024/10/16 16:00:43
所 在 地：美洲
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STUB1 Human/重组人STIP1同源性U-Box 包含蛋白1
产品编号：HSP-019
产品规格：10μg/50μg/1mg
产品规格：10μg/50μg/1mg
| Synonyms | CHIP, UBOX1, HSPABP2, NY-CO-7, SDCCAG7, STUB1, STIP1 homology ａnd U box-containing protein 1, Carboxy terminus of Hsp70-interacting protein, E3 ubiquitin-protein ligase CHIP, CLL-associated antigen KW-8, Antigen NY-CO-7. |
| Introduction | STUB1, is a cytoplasmic protein whose amino acid sequence is highly preserved across species. STUB1 interacts with the molecular chaperones Hsc70-Hsp70 ａnd Hsp90 through its TPR domain, whereas its U-box domain contains its E3 ubiquitin ligase activity. STUB1 interaction with these molecular chaperones lead to in client substrate ubiquitylation ａnd degradation by the proteasome. therefore, STUB1 acts to tilt the folding-refolding mechanism towards the degradative pathway, ａnd it serves as a link between the two. STUB1 inhibits anchorage-independent cell growth ａnd metastatic potential by degrading oncogenic proteins including SRC-3. Inhibition of tyrosine kinase activity of Her-2/neu by quercetin specifies an lateration in the Her-2/neu structure which promotes STUB1 recruitments ａnd down-regulation of Her-2/neu. STUB1 recognizes ａnd mediates degradation of toxic, oligomeric forms of alphaSyn. |
| Description | STUB1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 303 amino acids ａnd having a molecular mass of 34.8 kDa. STUB1 is expressed ａnd purified by proprietary chromatographic techniques. |
| Source | Escherichia Coli. |
| Physical Appearance | Sterile filtered colorless solution. |
| Formulation | The STUB1 protein solution contains 20mM Tris-HCl, pH-7.5, 10% glycerol ａnd 5mM DTT. |
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Avoid multiple freeze-thaw cycles. |
| Purity | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence | MKGKEEKEGG ARLGAGGGSP EKSPSAQELK EQGNRLFVGR KYPEAAACYG RAITRNPLVA VYYTNRALCY LKMQQHEQAL ADCRRALELD GQSVKAHFFL GQCQLEMESY DEAIANLQRA YSLAKEQRLN FGDDIPSALR IAKKKRWNSI EERRIHQESE LHSYLSRLIA AERERELEEC QRNHEGDEDD SHVRAQQACI EAKHDKYMAD MDELFSQVDE KRKKRDIPDY LCGKISFELM REPCITPSGI TYDRKDIEEH LQRVGHFDPV TRSPLTQEQL IPNLAMKEVI DAFISENGWV EDY. |
| Usage | ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
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