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HSPA5 Human/ 重组人热休克蛋白5-70kDa
点击次数：243发布时间：2012/10/31 19:56:27
更新日期：2024/10/16 16:00:43
所 在 地：美洲
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HSPA5 Human/ 重组人热休克蛋白5-70kDa
产品编号：HSP-021
产品规格：5μg/25μg/1mg
产品规格：5μg/25μg/1mg
| Synonyms | BIP, MIF2, GRP78, FLJ26106, HSPA5, 78 kDa glucose-regulated protein, GRP 78, Heat shock 70 kDa protein 5, Immunoglobulin heavy chain-binding protein, Endoplasmic reticulum lumenal Ca（2+）-binding protein grp78. |
| Introduction | Once Chinese hamster K12 cells are starved from glucose, the synthesis of GRP （glucose-regulated protein） expressed. HSPA5 also called BiP, is part of the HSP70 family ａnd plays a role in the folding ａnd assembly of proteins in the endoplasmic reticulum. HSPA5 plays a key role in monitoring protein transport through the cell. HSPA5 is a stress response protein which is induced by agents or conditions that adversely affect endoplasmic reticulum function. HSPA5 is crucial for the proper glycosylation, folding as well as for the maintenance of cell homeostasis ａnd the prevention of apoptosis. HSPA5 is differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia. HSPA5 guides posttranslational hepatitis B virus large envelope protein import into the mammalian ER. HSPA5 actively regulates multiple malignant phenotypes, including cell growth, migration, ａnd invasion. |
| Description | Recombinant Human HSPA5 produced in E.Coli is a single,non-glycosylated polypeptide chain containing 640 amino acids （20-650 a.a.） ａnd having a molecular mass of 71kDa. HSPA5 human recombinant is fused to an 8 amino acid His Tag at C-terminus ａnd purified by convential chromatogrpahy techniques. |
| Source | Escherichia Coli. |
| Physical Appearance | Sterile filtered colorless solution. |
| Formulation | The HSPA5 protein solution contains 20mM Tris-HCl, pH-8 & 10% Glycerol. |
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Avoid multiple freeze-thaw cycles. |
| Purity | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence | MEEDKKEDVG TVVGIDLGTT YSCVGVFKNG RVEIIANDQG NRITPSYVAF TPEGERLIGD AAKNQLTSNP ENTVFDAKRL IGRTWNDPSV QQDIKFLPFK VVEKKTKPYI QVDIGGGQTK TFAPEEISAM VLTKMKETAE AYLGKKVTHA VVTVPAYFND AQRQATKDAG TIAGLNVMRI INEPTAAAIA YGLDKREGEK NILVFDLGGG TFDVSLLTID NGVFEVVATN GDTHLGGEDF DQRVMEHFIK LYKKKTGKDV RKDNRAVQKL RREVEKAKRA LSSQHQARIE IESFYEGEDF SETLTRAKFE ELNMDLFRST MKPVQKVLED SDLKKSDIDE IVLVGGSTRI PKIQQLVKEF FNGKEPSRGI NPDEAVAYGA AVQAGVLSGD QDTGDLVLLD VCPLTLGIET VGGVMTKLIP RNTVVPTKKS QIFSTASDNQ PTVTIKVYEG ERPLTKDNHL LGTFDLTGIP PAPRGVPQIE VTFEIDVNGI LRVTAEDKGT GNKNKITITN DQNRLTPEEI ERMVNDAEKF AEEDKKLKER IDTRNELESY AYSLKNQIGD KEKLGGKLSS EDKETMEKAV EEKIEWLESH QDADIEDFKA KKKELEEIVQ PIISKLYGSA GPPPTGEEDT AELEHHHHHH. |
| Usage | ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
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