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HSF1 Human/重组人热休克转录因子1
点击次数：158发布时间：2012/10/31 20:05:38
更新日期：2024/10/16 16:00:43
所 在 地：美洲
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HSF1 Human/重组人热休克转录因子1
产品编号：HSP-017
产品规格：5μg/25μg/1mg
产品规格：5μg/25μg/1mg
| Synonyms | HSF-1, HSF1, HSTF-1, HSTF1, Heat shock factor protein 1, Heat shock transcription factor 1. |
| Introduction | The transcription of heat-shock genes is rapidly induced after temperature stress in response to environmental changes, ａnd it is also involved in oogenesis, spermatogenesis, ａnd placental development. Hsp90, is a major repressor of HSF1 gene. HSF1 is known for its participation in heat shock response. HSF1 protein regulates the transcription of hundreds of targets, such as genes involved in protein folding, detoxification, energy generation, carbohydrate metabolism, ａnd cell wall organization. HSF1 binds to MTA1 in vitro & in breast carcinoma. Suppression of estrogen-dependent transcription may contribute to role of HSF1 in cancer. Human cancer lines of diverse origins express higher dependence on HSF1 function to maintain proliferation ａnd survival than their non-transformed counterparts. HSF1 induces anticoagulation ａnd relaxation factors in vascular endothelial cells ａnd could therefore be used to treat cardiovascular disease. HSF1 is directly involved in the regulation of HO1 having an anti-oxidative role. NF-kappaB ａnd HSF1 are systemically activated in human acute pancreatitis. HSF1 activation protects against severity of pancreatitis. HSF is a vital transcription factor which plays a role in up-regulation of VDUP1 expression through stresses such as elevated density ａnd serum deprivation cultures. |
| Description | Recombinant HSF1 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 549 amino acids ａnd having a molecular mass of 59 kDa. The HSF1 protein is fused to His-Tag at N-terminus. |
| Source | Escherichia Coli. |
| Physical Appearance | Sterile filtered colorless solution. |
| Formulation | The HSF1 protein （1mg/ml） contains 20mM Tris pH-8, 50mM NaCl ａnd 1mM DTT. |
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Avoid multiple freeze-thaw cycles. |
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MDLPVGPGAA GPSNVPAFLT KLWTLVSDPD TDALICWSPS GNSFHVFDQG QFAKEVLPKY FKHNNMASFV RQLNMYGFRK VVHIEQGGLV KPERDDTEFQ HPCFLRGQEQ LLENIKRKVT SVSTLKSEDI KIRQDSVTKL LTDVQLMKGK QECMDSKLLA MKHENEALWR EVASLRQKHA QQQKVVNKLI QFLISLVQSN RILGVKRKIP LMLNDSGSAH SMPKYSRQFS LEHVHGSGPY SAPSPAYSSS SLYAPDAVAS SGPIISDITE LAPASPMASP GGSIDERPLS SSPLVRVKEE PPSPPQSPRV EEASPGRPSS VDTLLSPTAL IDSILRESEP APASVTALTD ARGHTDTEGR PPSPPPTSTP EKCLSVACLD KNELSDHLDA MDSNLDNLQT MLSSHGFSVD TSALLDLFSP SVTVPDMSLP DLDSSLASIQ ELLSPQEPPR PPEAENSSPD SGKQLVHYTA QPLFLLDPGS VDTGSNDLPV LFELGEGSYF SEGDGFAEDP TISLLTGSEP PKAKDPTVS. |
| Purity | Greater than 75.0% as determined by（a） Analysis by RP-HPLC. （b） Analysis by SDS-PAGE. |
| Usage | ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
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