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GADD45G Human/ 重组人生长抑制DNA损伤诱导因子Gamma
点击次数：166发布时间：2012/10/31 20:44:25
更新日期：2024/10/16 16:00:43
所 在 地：美洲
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GADD45G Human/ 重组人生长抑制DNA损伤诱导因子Gamma
产品编号：PRO-570
产品规格：10μg/50μg/1mg
产品规格：10μg/50μg/1mg
| Synonyms | DDIT2, GADD45gamma, GADD45G, Growth arrest ａnd DNA-damage-inducible protein GADD45 gamma, Cytokine-responsive protein CR6, DNA-damage-inducible transcript 2, DDIT-2, CR6, GRP17. |
| Introduction | GADD45G is part of the nuclear proteins to interact with various proteins whose transcript levels are raised after stressful growth arrest conditions ａnd treatment with DNA-damaging agents. GADD45G reacts to environmental stresses by mediating activation of the p38/JNK pathway which is mediated through their protein binding ａnd activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 ａnd JNK MAPKs. GADD45G acts as a new-age tumor suppressor however is being frequently inactivated epigenetically in multiple tumors. GADD45G mRNA expression is down-regulated in hepatocellular carcinoma. GADD45G causes cell cycle arrest at G2/M transition when transfected into Hep-G2 cells. GADD45 Gamma induction by androgens involves new protein synthesis. Overexpression of GADD45 Gamma inhibits cell growth ａnd causes morphological modifications in prostate cell lines thus GADD45 gamma takes part in differentiation induction by androgens. |
| Description | GADD45G Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 159 amino acids ａnd having a molecular mass of 17.1 kDa. |
| Source | Escherichia Coli. |
| Physical Appearance | Sterile Filtered colorless solution. |
| Formulation | The GADD45G protein solution contains 20mM Tris-HCl pH-7. |
| Stability | GADD45gamma although stable 4°C for 4 weeks, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles. |
| Amino Acid Sequence | MTLEEVRGQD TVPESTARMQ GAGKALHELL LSAQRQGCLT AGVYESAKVL NVDPDNVTFC VLAAGEEDEG DIALQIHFTL IQAFCCENDIDIVRVGDVQR LAAIVGAGEE AGAPGDLHCI LISNPNEDAW KDPALEKLSL FCEESRSVND WVPSITLPE. |
| Purity | Greater than 95.0% as determined by SDS-PAGE. |
| Usage | ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
