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GADD45B Human/重组人生长抑制DNA损伤诱导因子Beta
点击次数：182发布时间：2012/10/31 20:45:14
更新日期：2024/10/16 16:00:43
所 在 地：美洲
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GADD45B Human/重组人生长抑制DNA损伤诱导因子Beta
产品编号：PRO-563
产品规格：10μg/50μg/1mg
产品规格：10μg/50μg/1mg
| Synonyms | MYD118, GADD45BETA, GADD45B, Growth arrest ａnd DNA-damage-inducible protein GADD45 beta, Myeloid differentiation primary response protein MyD118, Negative growth regulatory protein MyD118, DKFZp566B133. |
| Introduction | GADD45B is part of the nuclear proteins to interact with various proteins whose transcript levels are raised after stressful growth arrest conditions ａnd treatment with DNA-damaging agents. GADD45B reacts to environmental stresses by mediating activation of the p38/JNK pathway which is mediated through their protein binding ａnd activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 ａnd JNK MAPKs. GADD45B is involved in the regulation of growth ａnd apoptosis. GADD45b takes part during chondrocyte terminal differentiation ａnd mediates MMP-13 gene expression. GADD45 in B cells is induced by CD40 via a mechanism that involves NF-kappa B ａnd that induction suppresses Fas-mediated killing. GADD45b is down-regulated in most cases of hepatocellular carcinoma （HCC）, ａnd is a molecular marker in the diagnosis of HCC ａnd as a possible therapeutic target. |
| Description | GADD45B Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 160 amino acids ａnd having a molecular mass of 17.8 kDa. |
| Source | Escherichia Coli. |
| Physical Appearance | Sterile Filtered colorless solution. |
| Formulation | The GADD45B protein solution contains 20mM Tris-HCl pH-7.5 ａnd 20% glycerol. |
| Stability | GADD45beta although stable 4°C for 4 weeks, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles. |
| Amino Acid Sequence | MTLEELVACD NAAQKMQTVT AAVEELLVAA QRQDRLTVGV YESAKLMNVD PDSVVLCLLA IDEEEEDDIA LQIHFTLIQS FCCDNDINIV RVSGMQRLAQ LLGEPAETQG TTEARDLHCL LVTNPHTDAW KSHGLVEVAS YCEESRGNNQ WVPYISLQER. |
| Purity | Greater than 95.0% as determined by SDS-PAGE. |
| Usage | ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
