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GADD45A Human/重组人生长抑制DNA损伤诱导因子Alpha
点击次数：171发布时间：2012/10/31 20:45:53
更新日期：2024/10/16 16:00:43
所 在 地：美洲
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GADD45A Human/重组人生长抑制DNA损伤诱导因子Alpha
产品编号：PRO-783
产品规格：5μg/25μg/1mg
产品规格：5μg/25μg/1mg
| Synonyms | Growth arrest ａnd DNA damage-inducible protein GADD45 alpha, DNA damage-inducible transcript 1 protein, DDIT-1, GADD45A, DDIT1, GADD45. |
| Introduction | Growth arrest ａnd DNA Damage-Inducible Protein （GADD45A） binds both Cdks ａnd PCNA. GADD45A is involved in DNA replication ａnd repair. GADD45A stimulates DNA excision repair in vitro ａnd inhibits entry of cells into S phase. GADD45A may serve as a link between p53-dependent cell cycle checkpoint ａnd DNA repair. The GADD45A gene belongs to a group of genes whose transcript levels are increased following stressful growth arrest conditions ａnd treatment with DNA-damaging agents. GADD45A responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. GADD45A binds to proliferating cell nuclear antigen. |
| Description | GADD45A produced in E.Coli is a single, non-glycosylated polypeptide chain containing 173 amino acids （1-165 a.a.） ａnd having a molecular mass of 19.4kDa. GADD45A is fused to 8 amino acids His Tag at C-terminus ａnd purified by proprietary chromatographic techniques. |
| Source | Escherichia Coli. |
| Physical Appearance | Sterile filtered colorless solution. |
| Formulation | The GADD45A protein solution contains 20mM Tris-HCl buffer （pH8.0）, 10% glycerol ａnd 0.1M NaCl. |
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Avoid multiple freeze-thaw cycles. |
| Purity | Greater than 85.0% as determined by SDS-PAGE. |
| Amino acid sequence | MTLEEFSAGE QKTERMDKVG DALEEVLSKA LSQRTITVGV YEAAKLLNVD PDNVVLCLLA ADEDDDRDVA LQIHFTLIQA FCCENDINIL RVSNPGRLAE LLLLETDAGP AASEGAEQPP DLHCVLVTNP HSSQWKDPAL SQLICFCRES RYMDQWVPVI NLPERLEHHH HHH. |
| Usage | ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
