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DDIT3 Human/重组人DNA损伤诱导转录因子3
点击次数：204发布时间：2012/11/1 18:10:58
更新日期：2024/10/16 16:00:43
所 在 地：美洲
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DDIT3 Human/重组人DNA损伤诱导转录因子3
产品编号：PRO-638
产品规格：5μg/20μg/1mg
产品规格：5μg/20μg/1mg
| Synonyms | DNA damage-inducible transcript 3, DDIT-3, Growth arrest ａnd DNA-damage-inducible protein GADD153, C/EBP-homologous protein, CHOP, DDIT3, GADD153, CEBPZ, CHOP10, MGC4154. |
| Introduction | DDIT3 reduces DNA-binding activity of C/EBP ａnd lap by forming heterodimers which don’t bind DNA. DDIT3, also known as GADD153, is a basic domain-leucine zipper（bZIP） transcription factor of C/EBP family. DDIT3 protein is up-regulated by several stresses, such as amino acid or glucose starvation, endoplasmic reticulum （ER） stress, osmotic stress ａnd hypoxia. DDIT3 protein is invloved in ER stress-mediated apoptosis ａnd in disease including diabetes, brain ischemia ａnd neurodegenerative disease. DDIT3 plays a role in asoprisnil-induced apoptosis. Hypoglycaemia-induced necrotic cell death of neuroblastoma cells is an active process mediated via the induction of the transcription factor DDIT3. DDIT3 plays an important role in melanoma progression. HRG stimulation of mammary epithelial cells induces the expression of DDIT3 mRNA ａnd protein ａnd transcription of DDIT3 promoter. |
| Description | DDIT3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 189 amino acids ａnd having a molecular mass of 21 kDa. The DDIT3 protein is fused to a 20 amino acids His tag at N-terminus. The DDIT3 is purified by proprietary chromatographic techniques. |
| Source | Escherichia Coli. |
| Physical Appearance | Sterile Filtered colorless solution. |
| Formulation | The DDIT3 protein solution （1mg/ml） contains 20mM Tris-HCl pH-8 ａnd 20% glycerol. |
| Stability | DDIT3 although stable 4°C for 4 weeks, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles. |
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MAAESLPFSF GTLSSWELEA WYEDLQEVLS SDENGGTYVS PPGNEEEESK IFTTLDPASL AWLTEEEPEP AEVTSTSQSP HSPDSSQSSL AQEEEEEDQG RTRKRKQSGH SPARAGKQRM KEKEQENERK VAQLAEENER LKQEIERLTR EVEATRRALI DRMVNLHQA. |
| Purity | Greater than 90.0% as determined by（a） Analysis by RP-HPLC. （b） Analysis by SDS-PAGE. |
| Usage | ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
