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FABP4 Human, His/重组人脂肪酸结合蛋白-4, His
点击次数：125发布时间：2012/11/1 18:27:43
更新日期：2024/10/16 16:00:43
所 在 地：美洲
产品型号：
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FABP4 Human, His/重组人脂肪酸结合蛋白-4, His
产品编号：PRO-566
产品规格：5μg/25μg/1mg
产品规格：5μg/25μg/1mg
| Synonyms | Fatty acid-binding protein adipocyte, AFABP, Fatty acid-binding protein 4, Adipocyte lipid-binding protein, ALBP, A-FABP, FABP4. |
| Introduction | Adipocyte fatty acid binding protein FABP4 is a 15 kDa member of the intracellular fatty acid binding protein （FABP） family, which is known for the ability to bind fatty acids ａnd related compounds （bile acids or retinoids） in an internal cavity. FABP4 is expressed in a differentiation-dependent fashion in adipocytes ａnd is a critical gene in the regulation of the biological function of these cells. In mice, targeted mutations in FABP4 provide significant protection from hyperinsulinemia ａnd insulin resistance in the context of both dietary ａnd genetic obesity. Adipocytes obtained from FABP4-deficient mice also have reduced efficiency of ipolysis in vitro ａnd in vivo, ａnd these mice exhibited moderately improved systemic dyslipidemia. Recent studies also demonstrated FABP4 expression in macrophages upon differentiation ａnd activation. In these cells, FABP4 modulates inflammatory responses ａnd cholesterol ester accumulation, ａnd total or macrophage-specific FABP4 deficiency confers dramatic protection against atherosclerosis in the apoE-/- mice. These results indicate a central role for FABP4 in the development of major components of the metabolic syndrome through its distinct actions in adipocytes ａnd macrophages. |
| Description | FABP4 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 132 amino acids ａnd having a molecular mass of 18 kDa. FABP4 is fused to His tag at N-terminus ａnd purified by standard chromatography techniques. |
| Source | Escherichia Coli. |
| Physical Appearance | Sterile Filtered colorless liquid formulation. |
| Formulation | FABP4 His-Tag is supplied in 20mM Tris HCL pH=8, 0.5mM DTT ａnd 50% glycerol. |
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles. |
| Purity | Greater than 95% as determined by SDS-PAGE. |
| Usage | ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
