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FABP4 Human/ 重组人脂肪酸结合蛋白-4
点击次数：130发布时间：2012/11/1 18:28:39
更新日期：2024/10/16 16:00:43
所 在 地：美洲
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FABP4 Human/ 重组人脂肪酸结合蛋白-4
产品编号：PRO-416
产品规格：2μg/10μg/1mg
产品规格：2μg/10μg/1mg
| Synonyms | Fatty acid-binding protein adipocyte, AFABP, Fatty acid-binding protein 4, Adipocyte lipid-binding protein, ALBP, A-FABP, FABP4. |
| Introduction | Adipocyte fatty acid binding protein FABP4 is a 15 kDa member of the intracellular fatty acid binding protein （FABP） family, which is known for the ability to bind fatty acids ａnd related compounds （bile acids or retinoids） in an internal cavity. FABP4 is expressed in a differentiation-dependent fashion in adipocytes ａnd is a critical gene in the regulation of the biological function of these cells. In mice, targeted mutations in FABP4 provide significant protection from hyperinsulinemia ａnd insulin resistance in the context of both dietary ａnd genetic obesity. Adipocytes obtained from FABP4-deficient mice also have reduced efficiency of ipolysis in vitro ａnd in vivo, ａnd these mice exhibited moderately improved systemic dyslipidemia. Recent studies also demonstrated FABP4 expression in macrophages upon differentiation ａnd activation. In these cells, FABP4 modulates inflammatory responses ａnd cholesterol ester accumulation, ａnd total or macrophage-specific FABP4 deficiency confers dramatic protection against atherosclerosis in the apoE-/- mice. These results indicate a central role for FABP4 in the development of major components of the metabolic syndrome through its distinct actions in adipocytes ａnd macrophages. |
| Description | 14.7 kDa protein containing 132 amino acid residues. MCDAFVGTWK LVSSENFDDY MKEVGVGFAT RKVAGMAKPN MIISVNGDVI TIKSESTFKN TEISFILGQE FDEVTADDRK VKSTITLDGG VLVHVQKWDG KSTTIKRKRE DDKLVVECVM KGVTSTRVYE RA. |
| Source | Escherichia Coli. |
| Physical Appearance | Sterile Filtered White lyophilized （freeze-dried） powder. |
| Formulation | Sterile filtered ａnd lyophilized from 0.5 mg/ml in 0.05M Acetate buffer pH4. |
| Solubility | 0.1M Acetate buffer pH4 ａnd let the lyophilized pellet dissolve completely. For conversion into higher pH value, we recommend intensive dilution by relevant buffer to a concentration of 10μg/ml. In higher concentrations the solubility of this antigen is limited. |
| Stability | Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. The lyophilized protein remains stable until the expiry date when stored at -20°C. |
| Purity | Greater than 90% as determined by SDS-PAGE. |
| Specificity | The amino acid sequence of the recombinant human FABP4 is 100% homologous to the amino acid sequence of the human FABP4. |
| Purification Method | Two-step procedure using size exclusion chromatography before ａnd after refolding. |
| Applications | Western blotting, ELISA. |
| Usage | Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
