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C3c Human/人补体 C3c
产品编号：PRO-555
产品规格：200μg/1mg/10mg
Synonyms Complement C3c, Complement Component C3c, C3c. Introduction The C3c component is central in both complement activation pathways, with different specific proteolytic systems cleaving it to form C3 convertase. Cleavage of C3 releases C3a ａnd the C3b fragment which is part of the alternative C3 convertase. C3 levels can be low because of decreased synthesis or due to consumption. High C3 levels are seen in highly acute or chronic inflammation, hepatic cholestasis ａnd during the third trimester of pregnancy.
Unwanted complement activation is a major cause of tissue damage in various pathological conditions ａnd contributes to quite a few immune complex diseases.
Compstatin is an effective inhibitor of the activation of complement component C3 ａnd thus blocks a central ａnd essential step in the complement cascade. The specific binding site on C3, the configuration in the bound form, ａnd the exact mode of action of compstatin are unknown. The crystal structure of compstatin in complex with C3c reveals that the compstatin-binding site is formed by the macroglobulin （MG） domains 4 ａnd 5. This binding site is part of the structurally stable MG-ring created by domains MG1–6 ａnd is distant from any other known binding site on C3. Compstatin does not modify the conformation of C3c, while compstatin itself undergoes a large conformational alteration upon binding. Description Human C3c produced in Human Plasma having a molecular mass of 180 KDa. Source Human Plasma. Physical Appearance Sterile Filtered White lyophilized （freeze-dried） powder. Formulation The Human Complement C3c was lyophilized from a sodium phosphate buffer, pH 7.2, containing 0.15M NaCl. Solubility It is recommended to reconstitute the lyophilized C3c in de-ionized water. Stability Human C3c although stable at room temperature for 3 weeks, should be stored between 2-8°C. Purity Greater than 96.0%. Usage ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
产品规格：200μg/1mg/10mg
| Synonyms | Complement C3c, Complement Component C3c, C3c. |
| Introduction | The C3c component is central in both complement activation pathways, with different specific proteolytic systems cleaving it to form C3 convertase. Cleavage of C3 releases C3a ａnd the C3b fragment which is part of the alternative C3 convertase. C3 levels can be low because of decreased synthesis or due to consumption. High C3 levels are seen in highly acute or chronic inflammation, hepatic cholestasis ａnd during the third trimester of pregnancy. Unwanted complement activation is a major cause of tissue damage in various pathological conditions ａnd contributes to quite a few immune complex diseases. Compstatin is an effective inhibitor of the activation of complement component C3 ａnd thus blocks a central ａnd essential step in the complement cascade. The specific binding site on C3, the configuration in the bound form, ａnd the exact mode of action of compstatin are unknown. The crystal structure of compstatin in complex with C3c reveals that the compstatin-binding site is formed by the macroglobulin （MG） domains 4 ａnd 5. This binding site is part of the structurally stable MG-ring created by domains MG1–6 ａnd is distant from any other known binding site on C3. Compstatin does not modify the conformation of C3c, while compstatin itself undergoes a large conformational alteration upon binding. |
| Description | Human C3c produced in Human Plasma having a molecular mass of 180 KDa. |
| Source | Human Plasma. |
| Physical Appearance | Sterile Filtered White lyophilized （freeze-dried） powder. |
| Formulation | The Human Complement C3c was lyophilized from a sodium phosphate buffer, pH 7.2, containing 0.15M NaCl. |
| Solubility | It is recommended to reconstitute the lyophilized C3c in de-ionized water. |
| Stability | Human C3c although stable at room temperature for 3 weeks, should be stored between 2-8°C. |
| Purity | Greater than 96.0%. |
| Usage | ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
