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Collagen-I Human /重组类人胶原蛋白I
点击次数：161发布时间：2012/11/2 15:18:16
更新日期：2024/10/16 16:00:43
所 在 地：美洲
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Collagen-I Human/重组类人胶原蛋白I
产品编号：PRO-479
产品规格：10mg/50mg/100mg
Collagen-I Human/重组类人胶原蛋白I
产品编号：PRO-479
产品规格：10mg/50mg/100mg
产品规格：10mg/50mg/100mg
| Introduction | Collagen, a major component of the extracellular matrix, is a fibrous protein that provides tensile strength to tissues giving them structural integrity. Collagen ａnd its derivative, gelatin, have been widely used in medical, pharmaceutical ａnd consumer products for more than 100 years. The supply of these materials, created from animal remains, is both abundant ａnd inexpensive. However, most formulations are not highly purified ａnd have the potential to cause an inflammatory reaction in some product users. In addition, concerns have been raised over the last several years about the potential for contamination of bovine products with the agent that causes mad cow disease ａnd its human variant, Creutzfeldt-Jakob Disease. Animal collagens are subject to extensive modifications that continue over the life of the molecule in the extracellular space. These differences influence both the extractability of collagens from tissue ａnd the biophysical characteristics of these collagens. As a result, collagens isolated from tissues exhibit significant lot-to-lot variability and, as bulk materials, are often analytically intractable. Products that contain animal-derived collagen can induce potentially harmful inflammatory or immune responses in humans ａnd pose risk of contamination with viruses or prions, potentially life-threatening pathogens. Recombinant collagens are essentially identical to the native collagen protein thereby reducing the risk of inflammation, immune response, ａnd disease as compared to animal-sourced collagen. |
| Description | DNA sequences encoding the human proalpha1（I）, proalpha2（I） ａnd both alpha ａnd beta subunits of prolyl hydroxylase were co-expressed in the yeast Pichia pastoris. Procollagen I was converted into mature collagen by a controlled proteinase digestion. |
| Source | Pichia pastoris. |
| Physical Appearance | Sterile Filtered colorless solution. |
| Formulation | The protein solution in 0.01M HCl. |
| Stability | Collagen-I should be stored at 2-8°C. |
| Purity | Greater than 99.0% as determined by SDS-PAGE. |
| Usage | Prospec＇s products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
