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BID Human/重组人BID激动剂
产品编号：PRO-627
产品规格：2μg/10μg/1mg
BID Human/重组人BID激动剂
产品编号：PRO-627
产品规格：2μg/10μg/1mg
BID Human/重组人BID激动剂
产品编号：PRO-627
产品规格：2μg/10μg/1mg
BID Human/重组人BID激动剂
产品编号：PRO-627
产品规格：2μg/10μg/1mg
BID Human/重组人BID激动剂
产品编号：PRO-627
产品规格：2μg/10μg/1mg
BID Human/重组人BID激动剂
产品编号：PRO-627
产品规格：2μg/10μg/1mg
BID Human/重组人BID激动剂
产品编号：PRO-627
产品规格：2μg/10μg/1mg
产品规格：2μg/10μg/1mg
| Synonyms | BH3-interacting domain death agonist, p22 BID, BID, FP497, MGC15319, MGC42355. |
| Introduction | BID accession number NP_001187 is a pro-apoptotic Bcl-2 protein having only the BH3 domain. In reaction to apoptotic signaling, BID interacts with another Bcl-2 family of cell death regulators, called Bax, they form a heterodimer resulting to the insertion of Bax into the outer mitochondrial membrane. Bax induces the opening of the mitochondrial voltage-dependent anion channel which lead to the release of cytochrome c ａnd other pro-apoptotic factors from the mitochondria resulting in activation of caspases. BID is a mediator of mitochondrial damage induced by caspase-8 （CASP8）. CASP8 cleaves BID, ａnd the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. The major proteolytic product p15 BID releasea cytochrome c. Isoform 1, Isoform 2 ａnd Isoform 4 induce ice-like proteases ａnd apoptosis while Isoform 3 does not induce apoptosis. |
| Description | BID Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 195 amino acids ａnd having a molecular mass of 21.9 kDa. |
| Source | Escherichia Coli. |
| Physical Appearance | Sterile Filtered colorless solution. |
| Formulation | The protein solution contains 20mM Tris-HCl pH-8 & 20% NaCl. |
| Stability | BID although stable 4°C for 4 weeks, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles. |
| Amino Acid Sequence | MDCEVNNGSS LRDECITNLL VFGFLQSCSD NSFRRELDAL GHELPVLAPQ WEGYDELQTD GNRSSHSRLG RIEADSESQE DIIRNIARHL AQVGDSMDRS IPPGLVNGLA LQLRNTSRSE EDRNRDLATA LEQLLQAYPR DMEKEKTMLV LALLLAKKVA SHTPSLLRDV FHTTVNFINQ NLRTYVRSLA RNGMD. |
| Purity | Greater than 95.0% as determined by（a） Analysis by RP-HPLC. （b） Analysis by SDS-PAGE. |
| Usage | ProSpec＇s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
